Abstract：
BACKGROUND:Prenatal lead exposure has been reported to affect infant growth and nervous system development, as well as to influence DNA methylation. We conducted an epigenome-wide association study to identify associations between prenatal lead exposure and cord blood DNA methylation in Korean infants. METHODS:Cord blood samples were assayed with the Illumina HumanMethylationEPIC BeadChip kits, and maternal blood lead levels during early and late pregnancy, as well as cord blood lead level, were measured. The association between CpG methylation and lead level was analyzed using the limma package, with adjusting for infant sex, maternal pre-pregnancy body mass index, and estimated leukocyte composition. RESULTS:Among 364 blood samples (182 males and 182 females), those for which maternal and cord blood lead concentrations during early and later pregnancy was known were used for analysis. Maternal lead concentration in blood during early pregnancy was significantly associated with the methylation status of specific positions. After data stratification by infant sex, we found that, in males, the level of maternal blood lead was associated with 18 CpG sites during early pregnancy, and with one CpG site near the NBAS gene, during late pregnancy. In female samples, there was no significant association between DNA methylation and lead concentrations. CONCLUSIONS:Prenatal lead exposure was associated with altered, gender-specific patterns of DNA methylation in Korean infants.
journal_name
Environ Resjournal_title
Environmental researchauthors
Park J,Kim J,Kim E,Kim WJ,Won Sdoi
10.1016/j.envres.2021.110767subject
Has Abstractpub_date
2021-01-27 00:00:00pages
110767eissn
0013-9351issn
1096-0953pii
S0013-9351(21)00061-Xpub_type
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