Effect of cadmium on the immune response in rats.

Abstract:

:Adult male inbred Wistar rats were given a subtoxic dose of cadmium (25 ppm) orally for 4 weeks prior to and during immunization with sheep erythrocytes (E). The control group received tap water during the experimental period. No difference in the antibody response to E was found between the two groups. Mononuclear peripheral blood cells from experimental and control rats were stimulated with concanavalin A (Con A). The experimental rats had received 25 ppm Cd in the drinking water from weaning until sacrifice at 15 weeks of age. There was no difference in [3H]thymidine incorporation between the cells of the experimental group and those of the control group. Addition of Cd at very low concentrations to the cultures significantly depressed the [3H]thymidine incorporation of the cells from both groups of rats. Thus, a subtoxic dose of Cd apparently had no effect on the in vivo immune response in rats.

journal_name

Environ Res

journal_title

Environmental research

authors

Wesenberg GB,Wesenberg F

doi

10.1016/0013-9351(83)90019-1

subject

Has Abstract

pub_date

1983-08-01 00:00:00

pages

413-9

issue

2

eissn

0013-9351

issn

1096-0953

pii

0013-9351(83)90019-1

journal_volume

31

pub_type

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