Preconception maternal polychlorinated biphenyl concentrations and the secondary sex ratio.

Abstract:

:The secondary sex ratio is the ratio of male to female live births and historically has ranged from 102 to 106 males to 100 females. Temporal declines have been reported in many countries prompting authors to hypothesize an environmental etiology. Blood specimens were obtained from 99 women aged 24-34 prior to attempting pregnancy and quantified for 76 polychlorinated biphenyl (PCB) congeners using dual column gas chromatography with electron capture detection. Women were prospectively followed until pregnancy or 12 cycles of trying. The odds of a male birth for three PCB groupings (total, estrogenic, anti-estrogenic) controlling for maternal characteristics were estimated using logistic regression. Among the 50 women with live births and PCB data, 26 female and 24 male infants were born (ratio 0.92). After adjusting for age and body mass index, odds of a male birth were elevated among women in the second (OR=1.29) and third (OR=1.48) tertiles of estrogenic PCBs; odds (OR=0.70) were reduced among women in the highest tertile of anti-estrogenic PCBs. All confidence intervals included one. The direction of the odds ratios in this preliminary study varied by PCB groupings, supporting the need to study specific PCB patterns when assessing environmental influences on the secondary sex ratio.

journal_name

Environ Res

journal_title

Environmental research

authors

Taylor KC,Jackson LW,Lynch CD,Kostyniak PJ,Buck Louis GM

doi

10.1016/j.envres.2006.04.009

subject

Has Abstract

pub_date

2007-01-01 00:00:00

pages

99-105

issue

1

eissn

0013-9351

issn

1096-0953

pii

S0013-9351(06)00082-X

journal_volume

103

pub_type

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