Subcutaneous kerosene toxicity in albino rats.

Abstract:

:Biochemical, histopathological, and hematological parameters were studied in male Wistar rats after repeated subcutaneous administration of commercial kerosene (0.5 ml/kg body wt, 6 days a week) for a period of 35 days. At necropsy, treatment-related increases in the weights of liver, spleen, and peripheral lymph nodes were noted. Correspondingly, there was an increase in DNA, RNA, protein, and lipid contents of liver and spleen. Histopathological examination of liver, spleen, thymus, kidney, adrenal, and lymph nodes revealed treatment-related lesions. Similarly, biochemical indices studied in liver revealed an increase in alkaline phosphatase and a decrease in benzo[a]pyrene hydroxylase levels. Furthermore serum cholinesterase, carboxylesterase, and albumin levels were significantly diminished while serum alkaline phosphatase levels were found to be greatly enhanced. The findings might be related as the likely systemic effects in workers upon percutaneous kerosene exposure during work.

journal_name

Environ Res

journal_title

Environmental research

authors

Rao GS,Kannan K,Goel SK,Pandya KP,Shanker R

doi

10.1016/0013-9351(84)90158-0

subject

Has Abstract

pub_date

1984-12-01 00:00:00

pages

516-30

issue

2

eissn

0013-9351

issn

1096-0953

pii

0013-9351(84)90158-0

journal_volume

35

pub_type

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