Ethnic differences in ambient air pollution and risk of acute ischemic stroke.

Abstract:

OBJECTIVES:To investigate the association between short-term changes in ambient pollution (particulate matter <2.5 μm in aerodynamic diameter (PM2.5) and ozone (O3)) and the risk of ischemic stroke among individuals living in a bi-ethnic community and whether this association is modified by ethnicity. METHODS:We identified incident ischemic stroke cases from the population-based Brain Attack Surveillance in Corpus Christi (BASIC) project between 2000 and 2012. Associations between PM2.5 (mean 24-h) and O3 (maximal 8-h) levels, measured on the same-day and lags of 1-3 days, and odds of ischemic stroke were assessed using a time-stratified case-crossover design and modeled using conditional logistic regression. We explored race/ethnicity (Mexican American versus non-Hispanic white) as a modifier by including interaction terms in the models. RESULTS:There were 2948 ischemic strokes with median age 71 years (IQR: 59-80). We observed no overall associations between the air pollutants and odds of ischemic stroke at any lag. When stratified by ethnicity, higher O3 was consistently associated with greater odds of ischemic stroke for non-Hispanic whites, but not for Mexican Americans. Higher PM2.5 was generally associated with lower odds of ischemic stroke for non-Hispanic whites but modestly greater odds for Mexican Americans. CONCLUSION:Ethnic differences in the associations between ischemic stroke and short-term exposures to O3 and PM2.5 were suggested indicating that further study in diverse populations may be warranted.

journal_name

Environ Res

journal_title

Environmental research

authors

Wing JJ,Adar SD,Sánchez BN,Morgenstern LB,Smith MA,Lisabeth LD

doi

10.1016/j.envres.2015.09.031

subject

Has Abstract

pub_date

2015-11-01 00:00:00

pages

62-7

issue

Pt A

eissn

0013-9351

issn

1096-0953

pii

S0013-9351(15)30097-9

journal_volume

143

pub_type

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