Abstract:
:The enhanced carcinogenicity of particle-associated polycyclic aromatic hydrocarbons (PAHs) has previously been explained by their prolonged retention in the lung due to the slow release of these substances from their carrier particles. However, the mathematical model presented here indicates that the lipid-aqueous heterogenic structure of the bronchial lining layer (BLL) in itself may constitute the major rate-determining step in the overall transport of PAHs from carrier particles to the bronchial epithelium. Conditions within the BLL are then as important for the resulting cellular burdens of PAHs in the lung as are the properties of the carrier particles for these hydrocarbons. Thus, in addition to other vital functions in the respiratory tract, the lipids in lung surfactant can also be important in protecting the lung from the action of lipophilic carcinogens.
journal_name
Environ Resjournal_title
Environmental researchauthors
Gerde P,Scholander Pdoi
10.1016/s0013-9351(87)80241-4subject
Has Abstractpub_date
1987-12-01 00:00:00pages
321-34issue
2eissn
0013-9351issn
1096-0953pii
S0013-9351(87)80241-4journal_volume
44pub_type
杂志文章abstract::In response to criticisms raised regarding a case-control study of canine malignant lymphoma, the results of several ancillary analyses are reported. The case-control study demonstrated a significant association between risk for canine malignant lymphoma and the opportunity for exposure to 2,4-dichlorophenoxyacetic ac...
journal_title:Environmental research
pub_type: 杂志文章,多中心研究
doi:10.1006/enrs.1995.1056
更新日期:1995-08-01 00:00:00
abstract::Within a cohort of 1022 consecutive singleton births in the Faroe Islands, we assessed prenatal methylmercury exposure from the maternal hair mercury concentration. At approximately 7 years of age, 917 of the children underwent detailed neurobehavioral examination. Little risk is thought to occur as long as the hair m...
journal_title:Environmental research
pub_type: 杂志文章
doi:10.1006/enrs.1997.3804
更新日期:1998-05-01 00:00:00
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journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/j.envres.2020.110554
更新日期:2020-12-03 00:00:00
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journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/0013-9351(84)90080-x
更新日期:1984-06-01 00:00:00
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journal_title:Environmental research
pub_type: 杂志文章
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更新日期:2020-12-13 00:00:00
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journal_title:Environmental research
pub_type: 杂志文章
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更新日期:2019-02-01 00:00:00
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journal_title:Environmental research
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journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/j.envres.2020.110022
更新日期:2020-11-01 00:00:00
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journal_title:Environmental research
pub_type: 杂志文章
doi:10.1006/enrs.1993.1060
更新日期:1993-04-01 00:00:00
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journal_title:Environmental research
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journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/j.envres.2015.02.030
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journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/j.envres.2016.02.029
更新日期:2016-05-01 00:00:00
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journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/j.envres.2017.06.027
更新日期:2017-10-01 00:00:00
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journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/j.envres.2020.110502
更新日期:2020-11-19 00:00:00
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journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/j.envres.2019.01.023
更新日期:2019-04-01 00:00:00
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journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/j.envres.2020.109166
更新日期:2020-04-01 00:00:00
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journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/j.envres.2019.01.047
更新日期:2019-04-01 00:00:00
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journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/j.envres.2008.02.009
更新日期:2008-07-01 00:00:00
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journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/j.envres.2015.12.006
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journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/j.envres.2015.07.019
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journal_title:Environmental research
pub_type: 杂志文章
doi:10.1006/enrs.1994.1046
更新日期:1994-07-01 00:00:00
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journal_title:Environmental research
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journal_title:Environmental research
pub_type: 杂志文章
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更新日期:2020-06-01 00:00:00
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journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/j.envres.2007.08.006
更新日期:2008-01-01 00:00:00
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journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/s0013-9351(05)80094-5
更新日期:1991-04-01 00:00:00
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journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/j.envres.2020.110349
更新日期:2020-10-28 00:00:00
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journal_title:Environmental research
pub_type: 杂志文章,meta分析
doi:10.1016/j.envres.2020.109970
更新日期:2020-11-01 00:00:00
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journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/j.envres.2017.05.041
更新日期:2017-10-01 00:00:00
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journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/j.envres.2017.03.028
更新日期:2017-07-01 00:00:00
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journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/j.envres.2015.08.024
更新日期:2015-10-01 00:00:00