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Ambient air pollution is associated with cardiac repolarization abnormalities in healthy adults.

Abstract：

BACKGROUND:Ambient air pollution has been associated with acute cardiovascular events; however, the underlying mechanisms remain incompletely understood. We aimed to examine the impacts of ambient air pollutants on cardiac ventricular repolarization in a highly polluted urban region. METHODS:Seventy-three healthy non-smoking young adults (66% female, mean age of 23.3 ± 5.4 years) were followed with four repeated 24-h electrocardiogram recordings in 2014-2016 in Beijing, China. Continuous concentrations of ambient particulates in size fractions of 5-560 nm diameter, black carbon (BC), nitrogen dioxide (NO2), carbon monoxide (CO), sulfur dioxide (SO2), and ozone (O3) were measured at a fixed-location air pollution monitoring station. Generalized linear mixed models, with adjustment for individual risk factors, time-varying factors and meteorological parameters, were used to evaluate the effects of air pollution on 5-min segments of heart rate-corrected QT interval (QTc), an index of cardiac ventricular repolarization. RESULTS:During the study period, the mean levels of number concentrations of particulates in size range of 5-560 nm (PNC5-560) were 20,711 particles/cm3. Significant increases in QTc of 0.56% (95% CI: 0.27, 0.84) to 1.76% (95% CI: 0.73, 2.79) were associated with interquartile range increases in PNC50-560 at prior 1-5 moving average days. Significant increases in QTc were also associated with increases in exposures to traffic-related air pollutants (BC, NO2 and CO), a combustion pollutant SO2, and the secondary pollutant O3. The associations were stronger in participants who were male, overweight, with abdominal obesity, and with higher levels of high-sensitivity C-reactive protein. CONCLUSIONS:Our findings suggest that exposures to higher levels of ambient particulates in small size fractions and traffic pollutants were associated with cardiac repolarization abnormalities in healthy adults, and the cardio-metabolic risks may modify the adverse cardiac effects attributable to air pollution.

journal_name

Environ Res

journal_title

Environmental research

authors

Xu H,Chen J,Zhao Q,Zhang Y,Wang T,Feng B,Wang Y,Liu S,Yi T,Liu S,Wu R,Zhang Q,Fang J,Song X,Rajagopalan S,Li J,Brook RD,Huang W

doi

10.1016/j.envres.2019.01.023

subject

Has Abstract

pub_date

2019-04-01 00:00:00

pages

239-246

eissn

0013-9351

issn

1096-0953

pii

S0013-9351(19)30023-4

journal_volume

171

pub_type

杂志文章

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Ambient air pollution is associated with cardiac repolarization abnormalities in healthy adults.