Abstract：
:Food would seem to be one of the main ways of animal and human contamination with polycyclic aromatic hydrocarbons (PAHs). In vivo studies suggest a transfer in intestinal epithelium by diffusion, which appears extensively governed by the physicochemical properties of PAHs, particularly lipophilicity. However, other mechanisms, such as metabolism, are considered to intervene. Our work aimed at testing in vitro intestinal metabolism and defining its impact on transepithelial transport of PAHs. Caco-2 cells were cultivated on permeable filters and incubated with 14C-labeled benzo[a]pyrene (BaP), pyrene (Pyr), and phenanthrene (Phe), which differ in their physicochemical properties. The results showed that the cells were able to metabolize the compounds. In basal media, Phe appeared to be the least hydroxylated molecule (45% after a 6-h exposure), followed by Pyr (65%) and finally BaP (96%). Inhibition of PAH metabolism showed a determinant effect on kinetics profiles. Transfer in the basal compartment of BaP, Pyr, and Phe radioactivities was, respectively, 26, 4, and 2 times lower with inhibitors, corroborating that intestinal metabolism of PAHs would have a positive impact on their transfer, an impact that increased with their lipophilicity. Furthermore, after a 6-h incubation, metabolites were also detected in apical medium. These findings suggested that intestinal metabolism might play a key role in intestinal barrier permeability and thus in the bioavailability of tested micropollutants.
journal_name
Environ Resjournal_title
Environmental researchauthors
Cavret S,Feidt Cdoi
10.1016/j.envres.2004.10.010subject
Has Abstractpub_date
2005-05-01 00:00:00pages
22-32issue
1eissn
0013-9351issn
1096-0953pii
S0013-9351(04)00216-6journal_volume
98pub_type
杂志文章abstract：:High concentrations of uranium (mean=620 microg/L) were detected in water samples collected from private wells in a residential community. Based on isotopic analyses, the source of the uranium contamination appeared to be from naturally occurring geological deposits. In homes where well water concentrations of uranium...
journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/S0013-9351(03)00115-4
更新日期：2004-03-01 00:00:00
abstract：:Atopic dermatitis is one of the most common inflammatory skin diseases among children and adults. Although the risk factors for atopic dermatitis have not yet been fully identified, exposure to mercury may be an important environmental risk factor. The objective of this study was to evaluate the association between me...
journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/j.envres.2011.02.003
更新日期：2011-05-01 00:00:00
abstract：:The objectives of this study were to examine levels of arsenic, cadmium, lead, mercury and selenium in edible tissue of seven species of marine fish collected from several Aleutian islands (in 2004) to determine: (1) interspecific differences, (2) locational differences (among Aleutian Islands), (3) size-related diffe...
journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/j.envres.2014.02.016
更新日期：2014-05-01 00:00:00
abstract：:Despite the behaviors of ZnO nanoparticles (ZnO NPs) in wastewater treatment processes have been widely explored, the impacts of ZnO NPs on the activated sludge's flocculation and sedimentation performances for solid-liquid separation have rarely been involved yet. In this study, ZnO NPs were observed to exert a dose-...
journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/j.envres.2020.110256
更新日期：2021-01-01 00:00:00
abstract：:Inhalation of welding fume (WF) can result in the deposition of toxic metals, such as manganese (Mn), in the brain and may cause neurological changes in exposed workers. Alterations in telomere length are indicative of cellular aging and, possibly, neurodegeneration. Here, we investigated the effect of WF inhalation o...
journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/j.envres.2019.108900
更新日期：2020-01-01 00:00:00
abstract：BACKGROUND:Exposure to fine particles in the atmosphere can adversely affect health and even lead to premature death. Recently, South Korea has attracted attention because of its rapid increase in the concentration of Particulate Matter (PM). OBJECTIVES:We estimated the economic benefits of reducing PM10 in Seoul, Sou...
journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/j.envres.2019.03.042
更新日期：2019-06-01 00:00:00
abstract：:Approximately 10% of women report smoking during pregnancy. The number of breastfeeding women who relapse back to smoking is even greater. Smoking may cause adverse changes to the milk's composition by not only reducing its protective properties, but also by affecting the infant's health. The pathophysiological mechan...
journal_title：Environmental research
pub_type： 杂志文章,评审
doi：10.1016/j.envres.2016.08.002
更新日期：2016-11-01 00:00:00
abstract：:Lead levels (Pb) have been linked to both hyper- and hypo-reactivity of hypothalamic-pituitary-adrenal axis (HPA) axis to acute stress in animals and humans. Similarly, allostatic load (AL), the 'wear and tear' of chronic stress, is associated with inadequate HPA axis activity. We examined whether Pb levels would be a...
journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/j.envres.2017.01.012
更新日期：2017-04-01 00:00:00
abstract：:The TiO2 based photocatalyst has great potential for the disinfection/inactivation of harmful pathogens (such as E.coli in aqueous media) along with its well-known usefulness on various chemical pollutants. The disinfection property of TiO2 is primarily attributed to surface generation of reactive oxygen species (ROS)...
journal_title：Environmental research
pub_type： 杂志文章,评审
doi：10.1016/j.envres.2017.01.018
更新日期：2017-04-01 00:00:00
abstract：:In Germany the impact of socioeconomic factors on environmental exposures and adverse housing conditions has been rarely studied up to now. The aim of our study was to assess whether and, if yes, how perceived exposure to noise and air pollution is influenced by socioeconomic status in Germany. We used data from a lar...
journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/j.envres.2005.09.008
更新日期：2006-06-01 00:00:00
abstract：:Although there are few environmental risk factors for breast cancer, some epidemiologic studies found that exposure to solar UV radiation (UVR) may lower risk. Prior epidemiologic studies are limited by narrow ambient UVR ranges and lack lifetime exposure assessment. To address these issues, we studied a cohort with r...
journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/j.envres.2016.08.013
更新日期：2016-11-01 00:00:00
abstract：:Cadmium has been linked to impaired cognitive function in adults and may cause behavioral, physiological and molecular abnormalities characteristic of Alzheimer's disease (AD) in animals. Evidence linking cadmium and AD in humans is limited, but supportive. In the most recent epidemiologic study, blood cadmium in U.S....
journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/j.envres.2017.05.011
更新日期：2017-08-01 00:00:00
abstract：:Lead arsenate (PbHAsO4) was used as an insecticide in Washington fruit orchards from 1905 to 1947. We examined exposure potential for children living in an agricultural community with historic PbHAsO4 use. Soil and housedust samples were collected from 58 residences. Families were asked about land use history, age of ...
journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/s0013-9351(03)00064-1
更新日期：2003-11-01 00:00:00
abstract：:The moving bed biofilm reactor (MBBR) has certain advantages, such as high wastewater treatment efficiency, low maintenance and operating costs, and simple operation. It has emerged as a valuable option for small decentralized facilities. The filling ratio, aeration mode and aeration intensity are the main factors tha...
journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/j.envres.2020.110614
更新日期：2020-12-17 00:00:00
abstract：:The effects of calcium and magnesium ions on the toxicity of cadmium to the eggs of the freshwater teleost, Oryzias latipes, were determined. Blastulae were immersed in free medium (Ca- and Mg-free), low-Ca medium (0.25 mM Ca), high-Ca medium (1.0 mM Ca), low-Mg medium (0.25 mM Mg), and high-Mg medium (1.0 mM Mg) with...
journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/s0013-9351(86)80087-1
更新日期：1986-06-01 00:00:00
abstract：:Polycyclic aromatic hydrocarbons (PAHs) are a class of pollutants that ubiquitously present in environment and hard to be degraded by microorganisms. Herein, we reported a novel photocatalytic-bacterial coupled removal system to treat PAH-polluted water. Using pyrene as the model pollutant, we demonstrated that the re...
journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/j.envres.2020.109135
更新日期：2020-04-01 00:00:00
abstract：:This study analyzed lead levels in scalp hair of child and adolescent street vendors in Istanbul. The mean lead in hair concentration found among children exposed to intensive motor traffic, 11.82 +/- 6.89 microg/g, was over five times higher than that in the control group, 2.70 +/- 2.30 microg/g. Vendors from a locat...
journal_title：Environmental research
pub_type： 杂志文章
doi：10.1006/enrs.2000.4044
更新日期：2000-05-01 00:00:00
abstract：:The interaction of aerosil particles with human erythrocytes was investigated by electron microscopy methods complemented with hemolysis and radio wave dielectric spectroscopy to elucidate the extent of morphological and functional modification induced by aerosil surface. Scanning electron microscopy and freeze-fractu...
journal_title：Environmental research
pub_type： 杂志文章
doi：10.1006/enrs.1998.3892
更新日期：1999-04-01 00:00:00
abstract：:One year-long criteria air pollutants data collected in Beijing were analyzed in this paper, which can support the research on formation, transport and human health effects of air pollutants. This is the first time to study the spatial and temporal variations of criteria pollutants in Beijing using hourly observationa...
journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/j.envres.2017.01.029
更新日期：2017-04-01 00:00:00
abstract：BACKGROUND:Legionellosis' treatment failures have been recently reported showing the possibility of resistance development to traditional therapy, especially in healthcare related disease cases. Environmental impact of antibiotic residues, especially in hospital waters, may act on the resistome of Legionella resulting ...
journal_title：Environmental research
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.envres.2018.02.030
更新日期：2018-07-01 00:00:00
abstract：:Heat waves are anticipated to worsen with climate change. India, an understudied area with >15% of the world's population, commonly experiences temperature extremes and already resembles potential future climates of more temperate regions. Registry data from local municipal corporations and government offices were col...
journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/j.envres.2019.108546
更新日期：2019-09-01 00:00:00
abstract：OBJECTIVES:Prenatal exposure of long chain polyunsaturated fatty acids (LCPUFA) are essential for normal fetal growth and neurodevelopment. Availability of LCPUFA depends mostly on maternal fish consumption. Fish consumption also exposes the fetus to mercury which is well known neurotoxicant. We analyzed the associatio...
journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/j.envres.2019.108682
更新日期：2019-11-01 00:00:00
abstract：:The effect of cadmium on thyroxine (T4) outer ring monodeiodination was studied in vivo and in vitro in the rat liver. One microgram of T4 was incubated with rat liver homogenates in 50 mM Tris--HCl buffer, pH 7.4, with or without 0.5, 5, and 50 mM dithiothreitol (DTT) for 60 min in the presence of 10(-8) to 10(-3) M ...
journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/s0013-9351(87)80206-2
更新日期：1987-04-01 00:00:00
abstract：:Blood lead (PbB) and hemoglobin levels (Hb) were determined in 40 battery repair/recycling shop workers, 16 radiator repair shop workers, and 20 children living in the immediate vicinity of these shops. Unexposed residents with similar socioeconomic status were also investigated. Mean PbB level was significantly highe...
journal_title：Environmental research
pub_type： 杂志文章
doi：10.1006/enrs.1999.4024
更新日期：2000-03-01 00:00:00
abstract：:Cadmium was bioassayed to observe cytogenetic effects in the water hyacinth (Eichhornia crassipes). Plants were exposed for 96 hr to freshwater containing 0.01, 0.05, 0.10, 1.5, and 10 mg/liter of cadmium. Metal concentrations in tissues were determined by atomic absorption spectrophotometry. The highest level was fou...
journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/0013-9351(84)90037-9
更新日期：1984-04-01 00:00:00
abstract：:It is important to follow up on the health status of inhabitants living in the methyl mercury-polluted area surrounding Minamata City, paying particular attention to diseases not only of the central nervous system but also of other organs. We have been carrying out such concentric studies for more than 10 years. We ha...
journal_title：Environmental research
pub_type： 杂志文章
doi：10.1006/enrs.1999.4014
更新日期：2000-06-01 00:00:00
abstract：:Prenatal exposure to organophosphorus pesticides (OPs) has been associated with different neurodevelopmental outcomes across different cohorts. A phenotypic approach may address some of these differences by incorporating information across scales and accounting for the complex correlational structure of neurodevelopme...
journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/j.envres.2017.07.023
更新日期：2017-10-01 00:00:00
abstract：BACKGROUND:Inorganic arsenic exposure is ubiquitous and both exposure and inter-individual differences in its metabolism have been associated with cardiometabolic risk. A more efficient arsenic metabolism profile (lower MMA%, higher DMA%) has been associated with reduced risk for arsenic-related health outcomes. This p...
journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/j.envres.2018.09.034
更新日期：2019-01-01 00:00:00
abstract：:Phthalates are frequently used in personal care products and plasticizers and phthalate exposure is ubiquitous in the US population. Exposure to phthalates during critical periods in utero has been associated with a variety of adverse health outcomes but the biological mechanisms linking these exposures with disease a...
journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/j.envres.2016.03.025
更新日期：2016-07-01 00:00:00
abstract：:The in vitro genotoxic and the soft-agar anchorage independent cell transformation ability of titanium dioxide nanoparticles (nano-TiO2) and its microparticulated form has been evaluated in human embryonic kidney (HEK293) and in mouse embryonic fibroblast (NIH/3T3) cells. Nano-TiO2 of two different sizes (21 and 50 nm...
journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/j.envres.2014.10.032
更新日期：2015-01-01 00:00:00
