Abstract：
:The ability of a methylene chloride extract of diesel exhaust particle (EDEP) to activate the aryl hydrocarbon receptor (AhR), bind to and activate the estrogen receptor (ER), and induce gene expression mediated via these nuclear receptors was examined in Hepa1c1c7 mouse hepatoma and MCF-7 human breast cancer cells. EDEP was able to induce a protein-DNA complex by gel retardation assays using a [gamma-32P]dATP-labeled dioxin response element (DRE). This complex could be effectively competed by a 150-fold excess of unlabeled DRE but not by a 150-fold excess of unlabeled mutated DRE. In Hepa1c1c7 cells that were transiently transfected with a DRE-regulated luciferase reporter gene, 4.6 ng/microliter EDEP treatment for 24 h resulted in a 22-fold induction of luciferase activity. In the same cell line, ethoxyresorufin-O-deethylase activity was significantly induced 20-fold following 24 h treatment with 4.6 ng/microliter EDEP. Using a competitive ligand binding assay, EDEP displaced bound tritiated E2 from the rat uterine ER in a dose-dependent manner with an IC50 of approximately 100 ng/microliter compared to the IC50 of E2, which was approximately 4.4x10(-4) ng/microliter (1.6 nM). In MCF-7 human breast cancer cells transiently transfected with a Gal4-regulated luciferase reporter gene (17m5-G-Luc) and a chimeric ER (Gal4-HEG0), treatment with 4.6 ng/microliter EDEP for 24 h resulted in a three-fold increase in luciferase activity (P<0.01) compared with the seven-fold increase observed with E2. This study demonstrates that EDEP is able to activate the AhR and ER and induce transcription of reporter genes regulated by these receptors' DNA response elements. Further study is required to identify the individual compound(s) responsible for the observed activity.
journal_name
Environ Resjournal_title
Environmental researchauthors
Meek MDdoi
10.1006/enrs.1998.3870subject
Has Abstractpub_date
1998-11-01 00:00:00pages
114-21issue
2eissn
0013-9351issn
1096-0953pii
S0013-9351(98)93870-1journal_volume
79pub_type
杂志文章abstract：:This study was designed to evaluate the effects of a diet rich in fish contaminated with MeHg, mimicking the typical diet of the Amazon riverside population, in rats. Animals were randomly assigned to one of three groups with eight rats in each group: Group I-control, received commercial ration; Group II-received a di...
journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/j.envres.2011.09.013
更新日期：2011-11-01 00:00:00
abstract：:Residential yard soil and indoor dust datasets from eight communities near historical mining, smelting, and refining operations were used to quantify soil track-in, an important factor in evaluating indoor exposures to soil metals and to set residential soil cleanup levels. Regression analyses were used to derive slop...
journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/j.envres.2020.109349
更新日期：2020-05-01 00:00:00
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journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/j.envres.2017.10.021
更新日期：2018-01-01 00:00:00
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journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/j.envres.2010.11.002
更新日期：2011-01-01 00:00:00
abstract：:The fractionation of natural organic matter (NOM) and its impact on the binding of quinolones to mineral surfaces and transport behavior under flow-through conditions have been scarcely investigated. In this study, the sorption and transport of a widely used quinolone antibiotic, Nalidixic acid (NA), were investigated...
journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/j.envres.2020.110187
更新日期：2020-12-01 00:00:00
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journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/j.envres.2020.109147
更新日期：2020-04-01 00:00:00
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journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/s0013-9351(05)80091-x
更新日期：1990-04-01 00:00:00
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journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/j.envres.2015.08.026
更新日期：2015-10-01 00:00:00
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journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/s0013-9351(86)80114-1
更新日期：1986-08-01 00:00:00
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journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/s0013-9351(05)80089-1
更新日期：1990-04-01 00:00:00
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journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/j.envres.2019.108717
更新日期：2019-11-01 00:00:00
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journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/j.envres.2008.01.004
更新日期：2008-06-01 00:00:00
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journal_title：Environmental research
pub_type： 传,历史文章,杂志文章
doi：10.1006/enrs.1997.3808
更新日期：1998-08-01 00:00:00
abstract：:The objective of the study was to determine the relationship between cadmium (Cd) intake and cadmium toxicity indicators by meta-analysis of literature data, in particular beta2-microglobulin (beta2MC), and to compare the results with the current Provisional Tolerable Weekly Intake (PTWI) set by FAO/WHO. The literatur...
journal_title：Environmental research
pub_type： 杂志文章,meta分析,评审
doi：10.1016/j.envres.2006.09.006
更新日期：2007-03-01 00:00:00
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journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/j.envres.2016.05.002
更新日期：2016-08-01 00:00:00
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journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/j.envres.2007.09.011
更新日期：2008-05-01 00:00:00
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journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/j.envres.2020.109977
更新日期：2020-10-01 00:00:00
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journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/s0013-9351(87)80013-0
更新日期：1987-02-01 00:00:00
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journal_title：Environmental research
pub_type： 杂志文章,评审
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更新日期：2021-01-05 00:00:00
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journal_title：Environmental research
pub_type： 杂志文章
doi：10.1006/enrs.1998.3836
更新日期：1998-05-01 00:00:00
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journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/j.envres.2017.03.032
更新日期：2017-07-01 00:00:00
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journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/j.envres.2020.109911
更新日期：2020-10-01 00:00:00
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journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/j.envres.2010.05.002
更新日期：2010-08-01 00:00:00
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journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/j.envres.2020.109166
更新日期：2020-04-01 00:00:00
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journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/j.envres.2015.12.012
更新日期：2016-04-01 00:00:00
abstract：BACKGROUND:Experimental studies show developmental toxicity of boron and we recently found impaired weight and length in newborns of mothers exposed to boron through drinking water during pregnancy. OBJECTIVES:To evaluate potential impact of pre- and postnatal boron exposure on infant anthropometry. METHODS:In our mo...
journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/j.envres.2019.01.012
更新日期：2019-04-01 00:00:00
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journal_title：Environmental research
pub_type： 杂志文章,评审
doi：10.1016/j.envres.2017.03.011
更新日期：2017-07-01 00:00:00
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journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/j.envres.2020.110463
更新日期：2020-11-13 00:00:00
abstract：BACKGROUND:Many women who smoke tobacco continue to do so during lactation, and many non-smoking women are exposed to second-hand tobacco smoke (SHS) during the period that she wishes to breastfeed. There are reports documenting the adverse effects of maternal smoking during lactation on their infant's health; however,...
journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/j.envres.2018.12.017
更新日期：2019-03-01 00:00:00
abstract：:Benzo[a]pyrene (BaP) is a useful indicator of exposure to polycyclic aromatic hydrocarbons (PAHs), airborne carcinogenic compounds. Radioimmunoassay was used to test for plasma BaP differences in 61 subjects divided into three groups based on geographic-demographic locale: urban-industrial, urban-residential, and oute...
journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/0013-9351(83)90196-2
更新日期：1983-10-01 00:00:00
