Abstract:
:The purpose of this work is to assess the effect of ozone, a reactive product of environmental photochemical oxidation, on lymphocytes of the lung. We exposed male Fischer rats to ozone at a concentration of 0.5 ppm for 20 hr/day for 1-14 days. Animals were treated with radioactive thymidine and were sacrificed at Day 1, 2, 3, 7, or 14 of exposure. Lungs and mediastinal lymph nodes were removed and prepared for histologic examination, evaluation of labeling indexes, and morphometric measurement. We examined two components of the lymphocyte response of the lung: the airway-related response, represented by the reaction of the bronchus-associated lymphoid tissue (BALT), and the deep lung-related response, represented by reaction of the mediastinal lymph node. Lymphocytes of both the BALT and the mediastinal lymph node showed elevated radioactive thymidine uptake; however, no evidence of cell death was observed at either site. The cells of the specialized epithelium covering the BALT (lymphoepithelium) showed increased vacuolization, indicating altered cellular function. The average size of BALTs was unchanged by ozone exposure. Under experimental conditions ozone can affect a variety of cells in the lung including bronchial epithelial cells, macrophages, and Type 1 cells. We have shown for the first time that in addition to these cells, the rat BALT also proliferates in response to ozone. In addition we confirm previous work in the mouse which shows that the mediastinal lymph node reacts as well. The airways can be affected by inflammation, can be targets of infection, and can respond to chemical irritants with bronchoconstrictive responses. They are an important target organ for hypersensitivity responses and are a primary site for pulmonary cancer formation. A role for lymphocytes has been implicated in each of these processes. Therefore, the clinical significance of ozone on BALT and mediastinal lymph node responses could be appreciable in terms of potentiation of, or protection against, such responses.
journal_name
Environ Resjournal_title
Environmental researchauthors
Dziedzic D,Wright ES,Sargent NEdoi
10.1016/s0013-9351(05)80089-1subject
Has Abstractpub_date
1990-04-01 00:00:00pages
194-208issue
2eissn
0013-9351issn
1096-0953pii
S0013-9351(05)80089-1journal_volume
51pub_type
杂志文章abstract::Exposure to air pollution in early years can exacerbate the risk of noncommunicable diseases throughout childhood and the entire life course. This study aimed to assess temperature, relative humidity (RH), carbon dioxide (CO2) and monoxide (CO), particulate matter (PM2.5, PM10), ultrafine particles, nitrogen dioxide (...
journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/j.envres.2020.110477
更新日期:2020-11-14 00:00:00
abstract::Since several workers engaged in polishing and engraving crystal articles were found to have higher than average blood levels of lead (560 micrograms/liter, range 80-560 micrograms/liter), we investigated the hypothesis that crystal dust releases lead in the human body. To test the hypothesis, two types of crystal pol...
journal_title:Environmental research
pub_type: 杂志文章
doi:10.1006/enrs.1997.3752
更新日期:1997-01-01 00:00:00
abstract::The recurrence of forest fires is degrading an important part of the Portuguese natural heritage namely its forest and soils. In this paper we present the case study of Cabeço da Vaca (Cabreira Mountain-northwest Portugal), where in recent decades, particularly in the 70s, there was a significant increase in the numbe...
journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/j.envres.2010.05.007
更新日期:2011-02-01 00:00:00
abstract::Particulate matter air pollution has been related to an increase in cardiopulmonary morbidity and mortality especially in susceptible subjects with a known cardiopulmonary disease. Recent studies suggest that PM(2.5) air pollution was associated with changes in heart rate variability (HRV). The purpose of this study w...
journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/j.envres.2008.04.005
更新日期:2008-09-01 00:00:00
abstract::In 1976, the New York Giants professional football team relocated to the newly constructed Meadowlands Sports Complex (MSC) in East Rutherford, NJ. Between 1980 and 1987 four team members developed cancer: one case each of non-Hodgkin's lymphoma, glioblastoma, angiosarcoma, and Hodgkin's disease. Because the surroundi...
journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/s0013-9351(05)80003-9
更新日期:1991-12-01 00:00:00
abstract::Polycyclic aromatic hydrocarbons (PAHs) are priority environmental mutagens and carcinogens that occur in the aquatic environment as mixtures rather than the individual compounds for which guidelines are issued. The present work aimed at understanding the interaction effects between carcinogenic and non-carcinogenic P...
journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/j.envres.2015.02.010
更新日期:2015-04-01 00:00:00
abstract::More and more studies suggest that prolonged exposure to EMF may cause adverse biological effects and point directly to a significantly negative correlation between EMF and human health, especially men fertility. In our previous study, we reported that this could be related to the EMF-induced reactive oxygen species f...
journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/j.envres.2018.05.035
更新日期:2018-10-01 00:00:00
abstract::Black crust in buildings can be formed as a result of different kind of chemical and physical reactions between the stone surface and environmental factors (e.g. acid aerosols emitted to the atmosphere, airborne particulate matter, etc.). Moreover, biological colonizations can also be present on them. This kind of pat...
journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/j.envres.2016.02.015
更新日期:2016-05-01 00:00:00
abstract::The objective of the study was to determine the relationship between cadmium (Cd) intake and cadmium toxicity indicators by meta-analysis of literature data, in particular beta2-microglobulin (beta2MC), and to compare the results with the current Provisional Tolerable Weekly Intake (PTWI) set by FAO/WHO. The literatur...
journal_title:Environmental research
pub_type: 杂志文章,meta分析,评审
doi:10.1016/j.envres.2006.09.006
更新日期:2007-03-01 00:00:00
abstract::Production of biochar from sewage sludge (SS) is consistent with the goal of sustainable resource recovery and promotes a wastewater-based circular economy. Thermochemical conversion of SS to biochar resolves two major issues simultaneously as it minimizes the cost of disposal and acts as a resource to eliminate the t...
journal_title:Environmental research
pub_type: 杂志文章,评审
doi:10.1016/j.envres.2020.110656
更新日期:2021-01-05 00:00:00
abstract:BACKGROUND:Although air pollution and social stress may independently increase childhood asthma, little is known on their synergistic effect on asthma, particularly in China with high levels of stress and air pollution. OBJECTIVES:To examine associations between exposure to a combination of parental stress and air pol...
journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/j.envres.2018.04.003
更新日期:2018-08-01 00:00:00
abstract::In response to criticisms raised regarding a case-control study of canine malignant lymphoma, the results of several ancillary analyses are reported. The case-control study demonstrated a significant association between risk for canine malignant lymphoma and the opportunity for exposure to 2,4-dichlorophenoxyacetic ac...
journal_title:Environmental research
pub_type: 杂志文章,多中心研究
doi:10.1006/enrs.1995.1056
更新日期:1995-08-01 00:00:00
abstract::Despite intense societal and scientific debates regarding glyphosate toxicity, it remains the most widely used herbicide. The primary metabolite of glyphosate, AMPA (aminomethylphosphonic acid), is the main contaminant detected in surface waters worldwide, both because of the extensive use of glyphosate and because of...
journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/j.envres.2020.109944
更新日期:2020-11-01 00:00:00
abstract::Exposure to inorganic fluoride (F) has been implicated in cardiovascular and kidney dysfunction mainly in adult populations. However, limited epidemiological information from susceptible populations, such as children, is available. In this study we evaluated the relationship of F exposure with some vascular and kidney...
journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/j.envres.2018.10.028
更新日期:2019-02-01 00:00:00
abstract::The loggerhead turtle (Caretta caretta) can be considered a good indicator species for studying the ecological impact of endocrine disrupting chemicals (EDCs) on wildlife. However, the effect of these environmental pollutants on nuclear steroid hormone signaling has not yet been addressed in sea turtles mainly due to ...
journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/j.envres.2017.07.024
更新日期:2017-10-01 00:00:00
abstract::Atmospheric pollution has emerged as a major public health issue in China. Public perception and acceptable risk levels of air pollution can prompt individual behavioral changes and play a major role in the public's response to health risks. Therefore, to explore these responses and evaluate what constitutes publicly ...
journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/j.envres.2017.05.012
更新日期:2017-08-01 00:00:00
abstract::During the 1920's and 1930's, a Niagara County, New York residential community, Belden Center, developed in tandem with two adjacent toxic waste disposal sites. During the period that they were in use, both sites were classified as public health hazards. Particularly between 1944 and 1979, as toxins were deposited, ne...
journal_title:Environmental research
pub_type: 杂志文章
doi:10.1006/enrs.2000.4089
更新日期:2000-11-01 00:00:00
abstract::A major challenge in both the design of epidemiologic studies of exposure to toxic agents and the interpretation of the findings is to recognize and to accommodate the complex biologic assumptions that underlie population-based research. Environmental health research is grounded on a scientific foundation that blends ...
journal_title:Environmental research
pub_type: 杂志文章,评审
doi:10.1016/s0013-9351(05)80229-4
更新日期:1992-10-01 00:00:00
abstract::The rapid transmission tendency, severity, and wide geographical spread of newly emerged novel coronavirus (SARS-CoV-2) in different environmental matrices, including water, air, and soil, has posed severe health, environmental, energy, and economic challenges worldwide. Despite the severe health effects, unprecedente...
journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/j.envres.2020.110443
更新日期:2021-02-01 00:00:00
abstract::Human exposure to poly- and perfluoroalkyl substances (PFASs) is widespread and has received considerable attention in recent years due to their link with adverse health outcomes, including bone health. Nevertheless, no earlier studies have reported serum PFAS concentrations, and their association with incident osteop...
journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/j.envres.2020.109676
更新日期:2020-08-01 00:00:00
abstract::Recent studies suggest potential adverse effects of methylmercury exposure on cardiovascular disease, although the evidence of association with hypertension is still inconsistent. Therefore, we evaluated the effects of methylmercury exposure on hypertension in Minamata. We used data derived from the 1971 population-ba...
journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/j.envres.2009.10.011
更新日期:2010-01-01 00:00:00
abstract::Nitrogen dioxide (NO2) and black carbon (BC) concentrations were measured inside London taxicabs across 40 work shifts in a real-world occupational study. The shifts were measured across five plug-in hybrid range-extender electric taxicabs (TXe City) and five diesel taxicabs (TX4 Diesel). The aim of this study was to ...
journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/j.envres.2021.110736
更新日期:2021-01-20 00:00:00
abstract::The effects of low-level lead exposure on neuropsychological status in the United States (US) general adult population have been reported, and the relationship between neuropsychiatric dysfunction and health risk behaviors including substance use and sexual risk taking is well established. However, the potential influ...
journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/j.envres.2014.05.037
更新日期:2014-11-01 00:00:00
abstract:BACKGROUND:The age-specific impacts of perinatal exposures to polychlorinated biphenyls (PCB), methylmercury (MeHg), and lead on child neurodevelopment remain controversial. Since we have already reported the prenatal effects of these chemicals on neurodevelopment in 3-day-old and 30-month-old children of a birth cohor...
journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/j.envres.2014.05.024
更新日期:2014-08-01 00:00:00
abstract:BACKGROUND:Children are sensitive to indoor environmental pollution. Up until now there has been a lack of data on air quality in child day care centers. OBJECTIVES:The aim of this study is to document the indoor environment quality of Paris child day care centers by repeated measurements, and to compare pollutant lev...
journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/j.envres.2011.06.009
更新日期:2011-11-01 00:00:00
abstract:BACKGROUND:Carbamate pesticides exposure have been linked with adverse health effects during developmental period. Based on 377 mother-child pairs from Sheyang Mini Birth Cohort Study, the present study aimed to assess carbofuranphenol exposure of three-year-old children and explore the associations between prenatal or...
journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/j.envres.2019.108590
更新日期:2019-10-01 00:00:00
abstract::Chlorine is a reactive gas used by humanity for over two centuries. Exposure to chlorine has occurred in a number of situations, including as a chemical warfare agent, in industrial and domestic exposures, and as a result of accidents and spills. The toxicology of chlorine is related almost entirely to effects in the ...
journal_title:Environmental research
pub_type: 杂志文章,评审
doi:10.1006/enrs.2000.4110
更新日期:2001-02-01 00:00:00
abstract::The capture and storage of CO2 in sub-seabed geological formations has been proposed as one of the potential options to decrease atmospheric CO2 concentrations in order to mitigate the abrupt and irreversible consequences of climate change. However, it is possible that CO2 leakages could occur during the injection and...
journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/j.envres.2015.11.006
更新日期:2016-01-01 00:00:00
abstract:BACKGROUND:Micronuclei (MNs) are extranuclear DNA-containing bodies and determining MN frequencies is a measure of genomic instability. An age-related increase in MN frequencies in lymphocytes has been quantified, but this effect has not yet been measured in nasal and buccal cells. METHODS:We determined the effect of ...
journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/j.envres.2019.108824
更新日期:2020-01-01 00:00:00
abstract::The relationship between bladder cancer and employment in occupations involving exposure to diesel exhaust was examined using data from a hospital-based case-control study of men aged 20 to 80 years in 18 hospitals in six U.S. cities, from January 1981 to May 1983. In this analysis, 194 cases and 582 controls were com...
journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/0013-9351(85)90129-x
更新日期:1985-08-01 00:00:00