Abstract:
:We analyzed the exogenous mineral particle concentration, size, type, and distribution for particles larger than 0.1 micron in the left lungs of 10 long-term male cigarette smokers. The mean number of particles found was 465 +/- 295 X 10(6)/g dry lung, of which 80% were kaolinite, micas, feldspars, free silica, and talc. Lead particles were extremely rare, despite their ubiquity in urban air. Overall there were no differences in particle concentration in upper vs lower lobes or central vs peripheral sampling sites. However, a significant correlation was found for upper lobe (r = 0.68), but not lower lobe (r = 0.08), particle concentration and amount of cigarette smoking. Overall, the geometric mean particle size was 0.6 +/- 2.1 microns; 56% of the particles in the upper lobes were larger than 0.75 micron in diameter, compared to 17% in the lower lobes, and the mean upper lobe particle size was greater than the mean lower lobe particle size for all individual mineral types. There was a remarkable homogeneity of mean particle size from patient to patient (mean intercase arithmetic particle size +/- SD of 0.8 +/- 0.1 micron). Particle size was not affected by the amount of smoking. We conclude that contrary to some published acute deposition data, there are no long-term differences in upper vs lower lobe particle concentration; total upper lobe particle retention is influenced by the amount of smoking as measured by pack-years, whereas total lower lobe particle retention appears to be independent by the amount of smoking; particles retained in the upper lobe are somewhat larger than those retained in the lower lobe, but the amount of smoking does not appear to influence retained particle size; the size of long-term retained particles most likely reflects largely atmospheric particle burden; and in the absence of overwhelming dust loads, the lung is able to regulate retained particle concentration and size in a fairly narrow range.
journal_name
Environ Resjournal_title
Environmental researchauthors
Churg A,Wiggs Bdoi
10.1016/s0013-9351(87)80013-0subject
Has Abstractpub_date
1987-02-01 00:00:00pages
121-9issue
1eissn
0013-9351issn
1096-0953pii
S0013-9351(87)80013-0journal_volume
42pub_type
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pub_type: 杂志文章
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journal_title:Environmental research
pub_type: 杂志文章,meta分析
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pub_type: 杂志文章
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更新日期:1987-02-01 00:00:00
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pub_type: 杂志文章
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journal_title:Environmental research
pub_type: 杂志文章
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更新日期:2009-08-01 00:00:00
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更新日期:2017-01-01 00:00:00
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更新日期:2021-02-01 00:00:00
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pub_type: 杂志文章
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更新日期:2017-02-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/s0013-9351(88)80010-0
更新日期:1988-02-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/j.envres.2016.12.013
更新日期:2017-04-01 00:00:00
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更新日期:2020-08-01 00:00:00
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journal_title:Environmental research
pub_type: 杂志文章
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更新日期:2017-07-01 00:00:00
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更新日期:2020-04-01 00:00:00
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更新日期:2019-09-01 00:00:00
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journal_title:Environmental research
pub_type: 杂志文章
doi:10.1006/enrs.2001.4281
更新日期:2001-09-01 00:00:00
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journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/s0013-9351(05)80206-3
更新日期:1992-06-01 00:00:00
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更新日期:2020-07-01 00:00:00
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pub_type: 杂志文章,评审
doi:10.1016/j.envres.2020.109819
更新日期:2020-09-01 00:00:00