A pesticide (dieldrin)-induced immunohemolytic anemia.

Abstract:

:The unusual presentation of a factory worker with severe hemolytic anemia which remitted following splenectomy prompted a search for an environmental cause for red cell injury. The investigation showed the presence of an immunoglobulin in the patient's serum and on the red cells and small amounts of complement on red cells. The patient's serum caused agglutination of a normal person's red cells only when dieldrin-coated, a reaction blocked by first reacting the serum with dieldrin. The spleen of the patient had a greater than normal concentration of dieldrin, the source of dieldrin being dietary. It is concluded that dieldrin became immunogenic and provoked a chemical immunohemolytic anemia. The spleen played a major role in destruction of red cells injured by the immunopathic process and in accumulation of the antigenic substance dieldrin.

journal_name

Environ Res

journal_title

Environmental research

authors

Hamilton HE,Morgan DP,Simmons A

doi

10.1016/0013-9351(78)90018-x

subject

Has Abstract

pub_date

1978-10-01 00:00:00

pages

155-64

issue

2

eissn

0013-9351

issn

1096-0953

pii

0013-9351(78)90018-X

journal_volume

17

pub_type

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