Validity of human nails as a biomarker of arsenic and selenium exposure: A review.

Abstract:

:Human nail clippings have been used in recent epidemiological studies as a routine bioindicator of arsenic and selenium exposure. To ensure sound application of this biomarker, however, it is important to consider properties and scientific knowledge pertaining to validation of this particular tool. In this review, the use of human nails to measure exposure to arsenic and selenium is discussed in the context of the biomarker validation framework. Literature related to both analytical procedures and intrinsic characteristics of the biomarker is reviewed. Specifically, the followings are addressed: sample collection and preparation methods, establishment of the exposure-biomarker relationship, intraindividual variability and reproducibility of measurements, and biomarker-disease investigations. Drawing from a rapidly growing body of literature, current knowledge of these biomarker validation steps is assessed. Therefore, this review brings attention to the important issue of biomarker validation, laying the framework for future studies measuring elemental composition of nails.

journal_name

Environ Res

journal_title

Environmental research

authors

Slotnick MJ,Nriagu JO

doi

10.1016/j.envres.2005.12.001

subject

Has Abstract

pub_date

2006-09-01 00:00:00

pages

125-39

issue

1

eissn

0013-9351

issn

1096-0953

pii

S0013-9351(05)00190-8

journal_volume

102

pub_type

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