Abstract：
:Male Wistar rats were exposed to 0.2 ppm ozone (O3) for 14 days and at intervals alveolar macrophages were collected by bronchoalveolar lavage to examine the effects of O3. The specific activities of glucose-6-phosphate dehydrogenase and glutathione peroxidase of alveolar macrophages increased to 1.6-fold (on the 3rd day) and 1.5-fold (on the 5th day), respectively, those of the control values. Similarly, the specific activities of pyruvate kinase, lactate dehydrogenase, and hexokinase also increased to 1.6-fold, 1.4-fold, and 1.2-fold, respectively, those of the control values on the 3rd day. The activities of all enzymes tested were maintained at significantly higher levels until the 14th day. Furthermore, the incorporation of [14C]thymidine into alveolar macrophages increased twice the control values on the 1st and 3rd days and was almost completely inhibited by the addition of 1.23 x 10(-4) M aphidicolin, a competitive inhibitor of DNA polymerase alpha. The number of alveolar macrophages collected from exposed animals also increased to 1.5-fold that of the control value on the 3rd day and was maintained at significantly higher level until the 14th day. It was noted that alveolar macrophages of small size preferentially increased between the 5th and 14th days. These results show that exposures to 0.2 ppm O3 induced a metabolic enhancement of the peroxidative metabolism, glycolysis, and DNA synthesis in alveolar macrophages and increased the macrophages of small size.
journal_name
Environ Resjournal_title
Environmental researchauthors
Mochitate K,Miura Tdoi
10.1016/s0013-9351(89)80023-4subject
Has Abstractpub_date
1989-06-01 00:00:00pages
79-92issue
1eissn
0013-9351issn
1096-0953pii
S0013-9351(89)80023-4journal_volume
49pub_type
杂志文章abstract：BACKGROUND:Pacific oysters along the North American coast from Washington to Alaska contain concentrations of cadmium (Cd) that are high by comparison with Atlantic oysters, frequently exceeding 2mug/g wet weight, but it is unclear whether this Cd is absorbed by consumers. OBJECTIVES:To determine the effect of oyster ...
journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/j.envres.2008.01.014
更新日期：2008-06-01 00:00:00
abstract：:The effect of inhalation of coal fly ash for 6 hr daily for 15 days has been studied on the hematology, blood chemistry, and histopathology of lungs and liver of rats up to 4 months from the first day of exposure. Fly ash inhalation significantly reduced WBC, RBC, and hemoglobin contents at earlier periods after expos...
journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/s0013-9351(87)80050-6
更新日期：1987-06-01 00:00:00
abstract：:Ash from dome-forming volcanoes poses a unique hazard to millions of people worldwide due to an abundance of respirable cristobalite, a crystalline silica polymorph. Crystalline silica is an established respiratory hazard in other mixed dusts, but its toxicity strongly depends on sample provenance. Previous studies su...
journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/j.envres.2015.11.020
更新日期：2016-02-01 00:00:00
abstract：OBJECTIVE:Longitudinal studies on neurobehavioral development in relation to prenatal and postnatal exposure to phthalates in school-age children and adolescents are limited. We investigated the association of prenatal and childhood phthalate exposure with the development of behavioral syndromes in 8-14-year-old childr...
journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/j.envres.2019.02.029
更新日期：2019-05-01 00:00:00
abstract：BACKGROUND:Previous diet intervention studies indicate that an organic diet can reduce urinary pesticide metabolite excretion; however, they have largely focused on organophosphate (OP) pesticides. Knowledge gaps exist regarding the impact of an organic diet on exposure to other pesticides, including pyrethroids and ne...
journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/j.envres.2019.01.024
更新日期：2019-04-01 00:00:00
abstract：BACKGROUND:Pesticide exposure has been found to cause renal damage and dysfunction in experimental studies, but epidemiological research on the renal effects of chronic low-level pesticide exposure is limited. We investigated the relationships between end-stage renal disease (ESRD) among wives of licensed pesticide app...
journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/j.envres.2015.10.002
更新日期：2015-11-01 00:00:00
abstract：:Polychlorinated biphenyls (PCBs) are ubiquitous environmental contaminants that disrupt thyroid hormone (TH) system function in numerous species. Previous studies have shown delayed metamorphosis in developing Xenopus laevis frogs exposed to PCBs, but the underlying molecular mechanisms have not been thoroughly invest...
journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/j.envres.2006.04.001
更新日期：2006-10-01 00:00:00
abstract：:Air pollution epidemiological studies suggest that elevated exposure to fine particulate matter (PM2.5) is associated with higher prevalence of term low birth weight (TLBW). Previous studies have generally assumed the exposure-response of PM2.5 on TLBW to be the same throughout a large geographical area. Health effect...
journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/j.envres.2015.06.044
更新日期：2015-10-01 00:00:00
abstract：:n-Hexane is used in industry as a solvent for adhesive, dry cleaning, and vegetable oil extraction. In 1963, the first case of severe polyneuropathy suspected to be caused by n-hexane was referred to us. Case studies, animal experiments, and field surveys on n-hexane poisoning were conducted, and preventive measures l...
journal_title：Environmental research
pub_type： 杂志文章,评审
doi：10.1006/enrs.1993.1091
更新日期：1993-07-01 00:00:00
abstract：BACKGROUND:Allergic sensitization during childhood is a dynamic process with a substantial rate of remission. Factors influencing this process are largely unknown. METHODS:We conducted a two-year prospective study among 121 schoolchildren (mean age, 5.8 years; 64 boys). We measured urea, club cell protein (CC16), β2-m...
journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/j.envres.2017.06.009
更新日期：2017-10-01 00:00:00
abstract：BACKGROUND:The COVID-19 pandemic has profoundly changed people's ability to recreate in public green spaces, which is likely to exacerbate the psychological impacts of the pandemic. In the current study, we seek to understand whether greenery can support mental health even with insufficient outdoor exposure in times of...
journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/j.envres.2020.110420
更新日期：2020-11-04 00:00:00
abstract：:The purpose of this investigation was to examine the relationship between airway responsiveness and the permeability of histamine through the airways in conscious sheep after exposure to ozone (O3). Airway responsiveness was assessed by measuring the change from baseline in mean pulmonary flow resistance following a c...
journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/0013-9351(84)90080-x
更新日期：1984-06-01 00:00:00
abstract：:This study examines the relationship between road traffic noise, self-reported sleep quality and mental health. The study is cross-sectional and based on data from a survey conducted in Oslo, Norway, in 2000. Psychological distress (Hopkins Symptom Checklist, HSCL-25) was measured along with self-reported somatic heal...
journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/j.envres.2014.02.010
更新日期：2014-05-01 00:00:00
abstract：INTRODUCTION:Childhood obesity is one of the most serious public health challenges of our times. Although an important body of experimental evidence highlights the obesogenic potential of endocrine disruptors such as bisphenol A (BPA), the epidemiological evidence remains inconclusive and limited. OBJECTIVE:To assess ...
journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/j.envres.2019.03.045
更新日期：2019-06-01 00:00:00
abstract：:Cardiovascular diseases (CVD) are responsible for around 20% of all deaths worldwide (approximately 14 million) and are the principal cause of death in all developed countries, accounting for 50% of all deaths. Variations in the annual per capita death rates in different countries are well documented. Less well known ...
journal_title：Environmental research
pub_type： 杂志文章,评审
doi：10.1016/s0013-9351(02)00009-9
更新日期：2003-05-01 00:00:00
abstract：:Soil heavy metal pollution assessment is an important procedure in soil quality and ecological risk management, for which different mathematical models have been developed. However, these models have often failed to consider the characteristics of both heavy metals and the polluted sites. In this study, we analyzed th...
journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/j.envres.2020.110246
更新日期：2021-01-01 00:00:00
abstract：:Chlorinated solvents (CS)-contaminated groundwater poses serious risks to the environment and public health. Microorganisms play a vital role in efficient remediation of CS. In this study, the microbial community (bacterial and archaeal) composition of three CS-contaminated groundwater wells located at an abandoned ch...
journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/j.envres.2020.109457
更新日期：2020-06-01 00:00:00
abstract：:Prenatal exposure to organophosphorus pesticides (OPs) has been associated with different neurodevelopmental outcomes across different cohorts. A phenotypic approach may address some of these differences by incorporating information across scales and accounting for the complex correlational structure of neurodevelopme...
journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/j.envres.2017.07.023
更新日期：2017-10-01 00:00:00
abstract：:Blood samples and questionnaire background data were collected from 96 children (age 2-14 years) living in urban, suburban, or rural areas with varying traffic intensity and industrial lead pollution in Uruguay. Spot samples of tap water were collected from the homes of 44 children, and samples of top soil were taken ...
journal_title：Environmental research
pub_type： 杂志文章
doi：10.1006/enrs.1997.3742
更新日期：1997-01-01 00:00:00
abstract：:Soil pollution from heavy metals poses a serious risk for environment and public health. Phytoremediation is an eco-friendly and cheaper alternative compared to chemical-physical techniques. We carried out in vitro tests where three microorganisms Trichoderma harzianum, Saccharomyces cerevisiae and Wickerhamomyces ano...
journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/j.envres.2020.109427
更新日期：2020-06-01 00:00:00
abstract：:In response to criticisms raised regarding a case-control study of canine malignant lymphoma, the results of several ancillary analyses are reported. The case-control study demonstrated a significant association between risk for canine malignant lymphoma and the opportunity for exposure to 2,4-dichlorophenoxyacetic ac...
journal_title：Environmental research
pub_type： 杂志文章,多中心研究
doi：10.1006/enrs.1995.1056
更新日期：1995-08-01 00:00:00
abstract：:Chitosan was used as crosslinking agent to load bimetal particles onto bentonite. The Fe-Al bimetal chitosan bentonite (Fe-Al bimetal @ bent) complex was prepared for the efficient removal of nitrate from wastewater and its by-products at low temperature. The samples were characterized by Scanning electron microscope ...
journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/j.envres.2020.109336
更新日期：2020-05-01 00:00:00
abstract：BACKGROUND:It is unknown if higher levels of ambient particulate matter (PM) exposure increase the risk for premature ventricular contractions (PVC) in a population-based study of men and women, and if this relationship varies by race or sex. METHODS:We examined the association of PM <2.5µm in diameter (PM2.5) concent...
journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/j.envres.2016.12.031
更新日期：2017-04-01 00:00:00
abstract：:It has been pointed out that, while an ecological study cannot determine whether radon causes lung cancer, it can test the validity of a linear-no threshold relationship between them. The linear-no threshold theory predicts a substantial positive correlation between the average radon exposure in various counties and t...
journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/s0013-9351(05)80119-7
更新日期：1990-12-01 00:00:00
abstract：BACKGROUND AND OBJECTIVE:Genetic and environmental factors have been recognized to play an important role in autism. The possibility that exposure to outdoor air pollution increases the risk of autism spectrum disorder (ASD) has been an emerging area of research. Herein, we present a systematic review, and meta-analysi...
journal_title：Environmental research
pub_type： 杂志文章,meta分析,评审
doi：10.1016/j.envres.2016.07.030
更新日期：2016-11-01 00:00:00
abstract：BACKGROUND:Hexavalent chromium (Cr(6+)) has long been recognized as an inhalation carcinogen. Useful data on its carcinogenicity by ingestion have been slower to develop. The 2008 NTP chronic bioassay of sodium dichromate dihydrate in drinking water found clear evidence of carcinogenicity in rodents and allows a genera...
journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/j.envres.2010.08.002
更新日期：2010-11-01 00:00:00
abstract：:More and more studies suggest that prolonged exposure to EMF may cause adverse biological effects and point directly to a significantly negative correlation between EMF and human health, especially men fertility. In our previous study, we reported that this could be related to the EMF-induced reactive oxygen species f...
journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/j.envres.2018.05.035
更新日期：2018-10-01 00:00:00
abstract：:N-Methyl-N-nitrosourea (MNU) and methyl methanesulfonate (MMS) were found to rapidly methylate glutathione (GSH) in vitro yielding S-methyl glutathione, as verified and quantitated by high-performance liquid chromatography and thin-layer chromatography. Formation of S-methylcysteine in the acid-hydrolyzate of the meth...
journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/s0013-9351(87)80042-7
更新日期：1987-08-01 00:00:00
abstract：:The humic substances are an abundant and important part of soil organic matter which plays many roles in ecosystems. On the other hand, forest fires are known to have a potential impact on the soil organic matter. Consequently, we chose to study the impact of forest fires on humic substances and the three relevant fra...
journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/j.envres.2010.03.005
更新日期：2011-02-01 00:00:00
abstract：:In 1925, Robert A. Kehoe enunciated a paradigm predicated upon categorical distinction between expectations and conjecture ("show me the data" mentality) from hard scientific facts on exposure outcomes. It led to a precedent-setting system of voluntary self-regulation by lead industry as a model for environmental cont...
journal_title：Environmental research
pub_type： 传,历史文章,杂志文章
doi：10.1006/enrs.1997.3808
更新日期：1998-08-01 00:00:00
