Abstract：
BACKGROUND:Allergic sensitization during childhood is a dynamic process with a substantial rate of remission. Factors influencing this process are largely unknown. METHODS:We conducted a two-year prospective study among 121 schoolchildren (mean age, 5.8 years; 64 boys). We measured urea, club cell protein (CC16), β2-microglobulin and albumin in nasal lavage fluid (NALF) and IgE to cat, pollen or house dust mite (HDM) in nasal mucosa fluid. RESULTS:Odds of persistent sensitization to any aeroallergen increased across baseline ascending tertiles of urea-adjusted β2-microglobulin or albumin and descending tertiles of albumin- or β2-microglobulin-adjusted CC16 (P-trend = 0.006, 0.02, 0.044 and 0.006, respectively). Persistent HDM sensitization also increased with baseline descending tertiles of raw or urea-adjusted CC16 (both P-trend = 0.007). Such strong associations were not observed with new-onset or remitted sensitization to any aeroallergen or with raw NALF concentrations of urea, albumin or β2-microglobulin. At baseline, house cleaning with bleach and chlorinated pool attendance emerged among the strongest and most consistent determinants of NALF biomarkers, being both associated with higher urea and lower CC16 in NALF. CONCLUSION:In young children, a defective nasal epithelium attributable to immaturity or stressors such as chlorination products is predictive of more persistent aeroallergen sensitization.
journal_name
Environ Resjournal_title
Environmental researchauthors
Bernard A,Sardella A,Voisin C,Dumont Xdoi
10.1016/j.envres.2017.06.009subject
Has Abstractpub_date
2017-10-01 00:00:00pages
145-152eissn
0013-9351issn
1096-0953pii
S0013-9351(17)30582-0journal_volume
158pub_type
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