Genotoxic differences by sex in nasal epithelium and blood leukocytes in subjects residing in a highly polluted area.

Abstract:

:We describe differences by sex in genotoxic damage found in a population of medical students exposed to a highly oxidative atmosphere, compared with a control group, measured by the single-cell gel electrophoresis assay and histological changes in nasal epithelium smears. Cells were obtained from the nasal epithelium and blood leukocytes. Higher DNA damage in nasal cells and leukocytes was found in males compared to females and control subjects. The percentage of squamous metaplastic changes in the nasal epithelium was also higher in males compared with females and controls. The co-mutation of normal nasal epithelium by squamous cells might modify its protective function in the nose, increasing the risk of damage to the lower respiratory tract. Although, as medical students, males and females were exposed to the same environment and activity patterns, male genotoxicity damage was higher in control and exposed subjects. More research should be done in order to identify direct or indirect sexual hormone intervention.

journal_name

Environ Res

journal_title

Environmental research

authors

Fortoul TI,Valverde M,López MC,Avila-Costa MR,Avila-Casado MC,Mussali-Galante P,Gonzalez-Villalva A,Rojas E,Ostrosky-Shejet P

doi

10.1016/S0013-9351(03)00093-8

subject

Has Abstract

pub_date

2004-03-01 00:00:00

pages

243-8

issue

3

eissn

0013-9351

issn

1096-0953

pii

S0013935103000938

journal_volume

94

pub_type

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