Abstract:
:We describe differences by sex in genotoxic damage found in a population of medical students exposed to a highly oxidative atmosphere, compared with a control group, measured by the single-cell gel electrophoresis assay and histological changes in nasal epithelium smears. Cells were obtained from the nasal epithelium and blood leukocytes. Higher DNA damage in nasal cells and leukocytes was found in males compared to females and control subjects. The percentage of squamous metaplastic changes in the nasal epithelium was also higher in males compared with females and controls. The co-mutation of normal nasal epithelium by squamous cells might modify its protective function in the nose, increasing the risk of damage to the lower respiratory tract. Although, as medical students, males and females were exposed to the same environment and activity patterns, male genotoxicity damage was higher in control and exposed subjects. More research should be done in order to identify direct or indirect sexual hormone intervention.
journal_name
Environ Resjournal_title
Environmental researchauthors
Fortoul TI,Valverde M,López MC,Avila-Costa MR,Avila-Casado MC,Mussali-Galante P,Gonzalez-Villalva A,Rojas E,Ostrosky-Shejet Pdoi
10.1016/S0013-9351(03)00093-8subject
Has Abstractpub_date
2004-03-01 00:00:00pages
243-8issue
3eissn
0013-9351issn
1096-0953pii
S0013935103000938journal_volume
94pub_type
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