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Effects of manganese on rat brain microsomal Mg2+-Na+-K+-ATPase: in vivo and in vitro studies.

Abstract：

:The effect of manganese on brain microsomal Mg2+-Na+K+-ATPase was examined both in vitro and in vivo. Daily intraperitoneal administration of MnCl2 . 4H2O (Mn2+, 6 mg/kg) to the rats for a period of 90 days produced 10% (P less than 0.05) inhibition in the activity of Mg2+-ATPase, and 72 and 63% increases in the contents of manganese and copper, respectively, in the microsomal fraction of brain. In in vitro studies, lower concentrations of Mn2+ activated while higher concentrations inhibited the activity of brain microsomal ATPase. Addition of equal concentrations of Mn2+ + Cu2+ (8 mM) in vitro produced 8% inhibition in the activity of Mg2+-ATPase and 83% inhibition in Na+-K+-ATPase. Free Cu2+ ions were able to antagonize the effect of Mn2+ on ATPase in vitro and inhibited the activity of Mg2+-Na+-K+-ATPase with more pronounced effect of Na+-K+-ATPase. The lack of change in the activity of Na+-K+-ATPase in the brain microsomes of rats administered manganese, in spite of a significant increase in copper, could not be explained. It is, however, evident that a manganese-induced elevation in brain copper was not responsible for initiating biochemical changes in manganese neurotoxicity.

journal_name

Environ Res

journal_title

Environmental research

authors

Shukla GS,Malhotra KM,Chandra SV

doi

10.1016/0013-9351(83)90208-6

subject

Has Abstract

pub_date

1983-10-01 00:00:00

pages

212-9

issue

1

eissn

0013-9351

issn

1096-0953

pii

0013-9351(83)90208-6

journal_volume

32

pub_type

杂志文章

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