Abstract：
BACKGROUND:Nonalcoholic fatty liver disease (NAFLD) is the leading cause of liver disease in children in the United States, and prevalence rates are rising. Smoking is associated with NAFLD, but the association of secondhand smoke exposure with NAFLD is unknown. AIMS:To investigate the association of secondhand tobacco exposure with NAFLD in children. METHODS:We surveyed parents/guardians of 304 children aged 3-12 years who had received an abdominal ultrasound at Penn State Hershey Medical Center. The survey addressed demographics, medical history, secondhand tobacco exposure, activity level, screen viewing time and other environmental exposures. A pediatric radiologist and sonographer reviewed the ultrasounds to grade the presence of bight liver compatible with NAFLD. We conducted logistic regression analysis to assess the association of secondhand tobacco exposure and NAFLD. RESULTS:54% of eligible potential participants responded to the survey. Fatty liver was present in 3% of the children. Increasing child age was associated with increased odds of NAFLD (OR 1.63 95% CI 1.1, 2.4). Reported child obesity was associated with increased odds of NAFLD (OR 44.5 95% CI 5.3, 371.7). The rate of NAFLD was higher in the smoke exposed group (6.7% vs. 1.7%). For every extra pack per day smoked at home, the odds of a child having NAFLD increased 1.8 times (AOR 1.8, 95% CI 1.2, 2.8), and any exposure increased a child's odds of NAFLD four-fold (AOR 4.0, 95% CI 1.02, 15.8). CONCLUSION:We found an association of secondhand smoke exposure and NAFLD in children. This may represent an area for future prevention efforts.
journal_name
Environ Resjournal_title
Environmental researchauthors
Lin C,Rountree CB,Methratta S,LaRusso S,Kunselman AR,Spanier AJdoi
10.1016/j.envres.2014.04.005subject
Has Abstractpub_date
2014-07-01 00:00:00pages
264-8eissn
0013-9351issn
1096-0953pii
S0013-9351(14)00095-4journal_volume
132pub_type
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