Abstract：
:A major challenge in both the design of epidemiologic studies of exposure to toxic agents and the interpretation of the findings is to recognize and to accommodate the complex biologic assumptions that underlie population-based research. Environmental health research is grounded on a scientific foundation that blends toxicology with epidemiology. Toxicology without human population studies often leads to findings uninterpretable for purposes of risk assessment. Epidemiologic studies are often less helpful than they could be because the variation in response is seldom addressed, the effects under study are often small in magnitude and easily confounded, and exposure estimates are crude. The net bias is to reduce the risk estimate, perhaps substantially. Biological variation has usually been treated as "noise" in the system but it is a more basic problem that lends itself to investigation and quantification. Improved modeling of the biological determinants of response is needed if results are to be generalizable and interpretable in mechanistic terms.
journal_name
Environ Resjournal_title
Environmental researchauthors
Guidotti TLdoi
10.1016/s0013-9351(05)80229-4subject
Has Abstractpub_date
1992-10-01 00:00:00pages
101-13issue
1eissn
0013-9351issn
1096-0953pii
S0013-9351(05)80229-4journal_volume
59pub_type
杂志文章,评审abstract：BACKGROUND:Exposure to far-field radiofrequency electromagnetic fields (RF-EMF) has raised public concerns in recent decades. However, it is not known if individuals' perception towards the health risks of RF-EMF is dependent on their knowledge of the objectively measured personal RF-EMF exposure levels. OBJECTIVES:Th...
journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/j.envres.2018.12.058
更新日期：2019-03-01 00:00:00
abstract：BACKGROUND:Previous diet intervention studies indicate that an organic diet can reduce urinary pesticide metabolite excretion; however, they have largely focused on organophosphate (OP) pesticides. Knowledge gaps exist regarding the impact of an organic diet on exposure to other pesticides, including pyrethroids and ne...
journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/j.envres.2019.01.024
更新日期：2019-04-01 00:00:00
abstract：:Chlorinated solvents (CS)-contaminated groundwater poses serious risks to the environment and public health. Microorganisms play a vital role in efficient remediation of CS. In this study, the microbial community (bacterial and archaeal) composition of three CS-contaminated groundwater wells located at an abandoned ch...
journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/j.envres.2020.109457
更新日期：2020-06-01 00:00:00
abstract：:In May 2000, the Agency for Toxic Substances and Disease Registry of the US government conducted a health investigation in response to community concerns regarding ambient and indoor hydrogen sulfide (H(2)S), odor, and health symptoms in Dakota City, Nebraska. The objective was to determine whether adult residents in ...
journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/j.envres.2003.08.005
更新日期：2004-05-01 00:00:00
abstract：BACKGROUND:Epidemiologic studies on the association between metals and body mass index (BMI) have been cross-sectional and have demonstrated inconsistent associations. Our study prospectively examined whether metals measured at baseline were associated with later BMI. We considered metals individually and as joint expo...
journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/j.envres.2020.109396
更新日期：2020-05-01 00:00:00
abstract：:The effect of intratracheal administration of fly ash, its benzene-extracted residue and the benzene extract has been studied on the activities of hepatic mixed-function oxidases in the rat. Fly ash and its fractions significantly increased the levels of cytochrome P-450, cytochrome b5, cytochrome b5 reductase, NADPH-...
journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/s0013-9351(87)80231-1
更新日期：1987-12-01 00:00:00
abstract：:With the increase of animal slurry produced from livestock production, the monitoring and mitigation of greenhouse gas (GHG) and ammonia (NH3) emissions represent a major issue. Life cycle assessment (LCA) has been used to evaluate the long-term environmental effects of applied strategies and technologies on cattle sl...
journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/j.envres.2020.110640
更新日期：2021-01-02 00:00:00
abstract：:Lead exposure during pregnancy remains a public health problem with potential lifelong impacts on children's growth and development. Mexico is unique in that stunting and obesity are both major public health concerns in children. This situation might be exacerbated by lead exposure which remains more common in Mexico ...
journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/j.envres.2016.10.014
更新日期：2017-01-01 00:00:00
abstract：:Bisphenol A (BPA) and its main substitute, bisphenol S (BPS), are synthetic organic compounds found in various consumer products, in particular food and beverage containers. Numerous reports have shown a link between bisphenol exposure, human contamination and increased health problems. BPA, BPS and their metabolites ...
journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/j.envres.2020.110336
更新日期：2020-10-20 00:00:00
abstract：:Hair is a well-established and widely used matrix for measuring mercury exposure of an individual. Although a variety of washing procedures to remove external mercury contamination have been proposed, no standardized procedures are available yet. In this study, different washing reagents like l-cysteine (Cys), 2-merca...
journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/j.envres.2007.07.003
更新日期：2008-05-01 00:00:00
abstract：:Fish consumption from the Great Lakes and the St. Lawrence River has been decreasing over the last years due to advisories and increased awareness of the presence of several contaminants. Methylmercury (MeHg), a well-established neurotoxicant even at low levels of exposure, bioaccumulates to differing degrees in vario...
journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/j.envres.2003.12.007
更新日期：2004-07-01 00:00:00
abstract：:Endocrine disrupting chemicals (EDCs) in the environment are considered to be a contributing factor to the decline in the sperm quality. With growing evidence of the harmful effects of EDCs on the male reproductive system, we tested the hypothesis that prenatal exposure to an environmentally relevant phthalate mixture...
journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/j.envres.2019.02.017
更新日期：2019-05-01 00:00:00
abstract：:Despite the ubiquity of microplastics (MPs) in aquatic environments and their proven ability to carry a wide variety of chemicals, very little is known about the impacts of virgin or contaminant-loaded MPs on organisms. The primary aim of this study was to investigate the impacts of virgin or phenanthrene (Phe)-loaded...
journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/j.envres.2016.07.024
更新日期：2016-11-01 00:00:00
abstract：BACKGROUND:Congenital limb deficiencies (CLDs) are a relatively common group of birth defects whose etiology is mostly unknown. Recent studies suggest maternal air pollution exposure as a potential risk factor. AIM:To investigate the relationship between ambient air pollution exposure during early pregnancy and offspr...
journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/j.envres.2019.108716
更新日期：2019-12-01 00:00:00
abstract：:The relationship between external exposure and internal doses of polycyclic aromatic hydrocarbons (PAHs) has not been established for people living in industrial areas. This study was carried out to estimate the relationship between particle-phase PAH exposure and urinary 1-hydroxypyrene (1-OHP) levels among the adult...
journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/j.envres.2014.10.007
更新日期：2015-01-01 00:00:00
abstract：:Chlorine is a reactive gas used by humanity for over two centuries. Exposure to chlorine has occurred in a number of situations, including as a chemical warfare agent, in industrial and domestic exposures, and as a result of accidents and spills. The toxicology of chlorine is related almost entirely to effects in the ...
journal_title：Environmental research
pub_type： 杂志文章,评审
doi：10.1006/enrs.2000.4110
更新日期：2001-02-01 00:00:00
abstract：BACKGROUND:Consistent evidence has shown excess mortality associated with cold temperature, but some important details of the cold-mortality association (e.g. slope and threshold) have not been adequately investigated and few studies focused on the cold effect in high-altitude areas of developing countries. We attempte...
journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/j.envres.2016.06.029
更新日期：2016-10-01 00:00:00
abstract：:The stability of the linings of packaging that is in contact with the goods stored has been of major concern during decades of the development of packaging materials. In this work, an attempt was undertaken to assess the applicability of using two bioassays (Microtox® and XenoScreen YES/YAS) in estimating the stabilit...
journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/j.envres.2018.05.004
更新日期：2018-08-01 00:00:00
abstract：:Recent studies from the Madre de Dios region of Peru report elevated mercury exposure among the general population. Our objective was to assess mercury exposure, risk factors, risk perceptions, and knowledge among women of childbearing age, a population of concern due to risks to infant and fetal health. We collected ...
journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/j.envres.2019.108786
更新日期：2019-12-01 00:00:00
abstract：:We developed a high throughput analytical method using on-line solid phase extraction coupled with isotope dilution high-performance liquid chromatography-tandem mass spectrometry (on-line SPE-HPLC-MS/MS) to simultaneously determine the concentrations of 17 polyfluoroalkyl chemicals (PFCs) in house dust. The sample pr...
journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/j.envres.2009.01.005
更新日期：2009-07-01 00:00:00
abstract：:Wood dust is one of the most common occupational exposures, with about 3.6 million of workers in the wood industry in Europe. Wood particles can deposit in the nose and the respiratory tract and cause adverse health effects. Occupational exposure to wood dust has been associated with malignant tumors of the nasal cavi...
journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/j.envres.2019.03.058
更新日期：2019-06-01 00:00:00
abstract：OBJECTIVES:Uranium miners are chronically exposed to radon and its progeny, which are known to cause lung cancer and may be associated with leukemia. This study was undertaken to evaluate risk of non-lung solid cancers among uranium miners in Příbram region, Czech Republic. METHODS:A retrospective stratified case-coho...
journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/j.envres.2011.01.008
更新日期：2011-04-01 00:00:00
abstract：:Seventy-two strains of Hg-resistant bacteria (Pseudomonas) were isolated on agar plates containing 40 micrograms/ml of HgCl2 from Minamata Bay sediment, which was heavily polluted with mercury (45.8 micrograms/g). The minimal inhibitory concentrations (MICs) of mercurial compounds were determined for the Hg-resistant ...
journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/s0013-9351(86)80081-0
更新日期：1986-06-01 00:00:00
abstract：:Indicators for cooking fuel pollution are needed to determine the extent of fuel-related problems in developing countries and to assess the success of measures undertaken to reduce such problems. It is proposed that eye irritation in the form of tears or smarting eyes during cooking time [tears while cooking (TWC)] is...
journal_title：Environmental research
pub_type： 杂志文章
doi：10.1006/enrs.1997.3771
更新日期：1997-10-01 00:00:00
abstract：:This paper discusses sampling and design considerations relevant to the estimation of exposure to organochlorine compounds in epidemiological studies. We consider exposures measured directly via biomarkers of exposure in the body. It is critical for the design, implementation, and evaluation of studies that epidemiolo...
journal_title：Environmental research
pub_type： 杂志文章
doi：10.1006/enrs.1994.1026
更新日期：1994-04-01 00:00:00
abstract：BACKGROUND:There has been no investigation to date of adults with metabolic syndrome examining the association of short and long-term exposure to fine particulate matter (PM2.5) air pollution with cardiovascular-disease related inflammatory marker (WBC and CRP) levels in a nationally representative sample. The goal of ...
journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/j.envres.2017.11.042
更新日期：2018-02-01 00:00:00
abstract：:In this research, the concentrations of six heavy metals (Zn, Pb, Ni, Fe, Cd, and Cr) in electronic cigarette (EC) solutions were determined to assess their association with EC use patterns. To this end, their contents were analyzed under three conditions: (1) ECL I: EC liquid was directly taken from EC liquid bottles...
journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/j.envres.2019.04.025
更新日期：2019-07-01 00:00:00
abstract：:A simple and innovative mechanochemical approach was employed to synthesize Ag-polysaccharide nanohybrid materials that were proved to exhibit remarkable surface properties and structures for biomedical applications. The synthesized Ag nanomaterials possessed an unprecedented low cytotoxicity against human cell lines ...
journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/j.envres.2017.01.010
更新日期：2017-04-01 00:00:00
abstract：:Large areas of mainland China have been suffering frequently from heavy haze pollution during the past years, which feature high concentrations of fine particulate matter (PM2.5, particulate matters with aerodynamic diameters less than 2.5 μm) and low visibility. Moreover, these areas manifested strong regional comple...
journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/j.envres.2020.109368
更新日期：2020-05-01 00:00:00
abstract：:The major predictors of health risk from pesticide exposure are quantity and toxicity of pesticides reaching end-users, field workers, and persons (including children) with casual and indirect exposures to field and food residues, drift, and contaminated groundwater. Past work in Israel and the Palestinian National Au...
journal_title：Environmental research
pub_type： 杂志文章
doi：10.1006/enrs.1997.3717
更新日期：1997-01-01 00:00:00
