Abstract:
OBJECTIVE:Gut microorganisms contribute to the metabolism of environmental toxicants, including methylmercury (MeHg). Our main objective was to investigate whether associations between biomarkers for prenatal MeHg exposure and maternal gut microbiota differed between early and late gestation. METHODS:Maternal blood and stool samples were collected during early (8.3-17 weeks, n=28) and late (27-36 weeks, n=24) gestation. Total mercury and MeHg concentrations were quantified in biomarkers, and inorganic mercury was estimated by subtraction. The diversity and structure of the gut microbiota were investigated using 16S rRNA gene profiling (n = 52). Biomarkers were dichotomized, and diversity patterns were compared between high/low mercury concentrations. Spearman's correlation was used to assess bivariate associations between MeHg biomarkers (stool, blood, and meconium), and 23 gut microbial taxa (genus or family level, >1% average relative abundance). RESULTS:Within-person and between-person diversity patterns in gut microbiota differed between early/late gestation. The overall composition of the microbiome differed between high/low MeHg concentrations (in blood and stool) during early gestation, but not late gestation. Ten (of 23) taxa were significantly correlated with MeHg biomarkers (increasing or decreasing); however, associations differed, depending on whether the sample was collected during early or late gestation. A total of 43% of associations (69/161) reversed the direction of correlation between early/late gestation. CONCLUSIONS:The time point at which a maternal fecal sample is collected may yield different associations between gut microorganisms and MeHg biomarkers, which may be due in part to remodeling of maternal microbiota during pregnancy. Our results suggest the effectiveness of dietary interventions to reduce prenatal MeHg exposure may differ between early and late gestation.
journal_name
Environ Resjournal_title
Environmental researchauthors
Rothenberg SE,Wagner CL,Hamidi B,Alekseyenko AV,Andrea Azcarate-Peril Mdoi
10.1016/j.envres.2019.01.014subject
Has Abstractpub_date
2019-05-01 00:00:00pages
700-712eissn
0013-9351issn
1096-0953pii
S0013-9351(19)30017-9journal_volume
172pub_type
杂志文章abstract::Chronic exposure to hydrogen sulfide (H(2)S) in the parts per billion-parts per million range occurs in the population of Rotorua, a city built upon an actively degassing geothermal field in the Taupo Volcanic Zone, New Zealand. H(2)S is acutely toxic at high concentrations but little is understood of the health effec...
journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/j.envres.2005.08.006
更新日期:2006-06-01 00:00:00
abstract:BACKGROUND:Congenital limb deficiencies (CLDs) are a relatively common group of birth defects whose etiology is mostly unknown. Recent studies suggest maternal air pollution exposure as a potential risk factor. AIM:To investigate the relationship between ambient air pollution exposure during early pregnancy and offspr...
journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/j.envres.2019.108716
更新日期:2019-12-01 00:00:00
abstract::OMS-2 is one of the most promising catalysts for carcinogenic benzene elimination, and single-type alkali metals are typically introduced into the OMS-2 tunnels to modify its catalytic activity. Here, we reported a novel approach for significantly increasing the catalytic activity of OMS-2 via the simultaneous introdu...
journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/j.envres.2020.110146
更新日期:2020-12-01 00:00:00
abstract::Chlorinated solvents (CS)-contaminated groundwater poses serious risks to the environment and public health. Microorganisms play a vital role in efficient remediation of CS. In this study, the microbial community (bacterial and archaeal) composition of three CS-contaminated groundwater wells located at an abandoned ch...
journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/j.envres.2020.109457
更新日期:2020-06-01 00:00:00
abstract::Male Wistar rats were exposed to 0.2 ppm ozone (O3) for 14 days and at intervals alveolar macrophages were collected by bronchoalveolar lavage to examine the effects of O3. The specific activities of glucose-6-phosphate dehydrogenase and glutathione peroxidase of alveolar macrophages increased to 1.6-fold (on the 3rd ...
journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/s0013-9351(89)80023-4
更新日期:1989-06-01 00:00:00
abstract:BACKGROUND:Although air pollution and social stress may independently increase childhood asthma, little is known on their synergistic effect on asthma, particularly in China with high levels of stress and air pollution. OBJECTIVES:To examine associations between exposure to a combination of parental stress and air pol...
journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/j.envres.2018.04.003
更新日期:2018-08-01 00:00:00
abstract::Climate change is one of the biggest and most urgent challenges for the 21st century. Rising average temperatures and ocean levels, altered precipitation patterns and increased occurrence of extreme weather events affect not only the global landscape and ecosystem, but also human health. Multiple environmental factors...
journal_title:Environmental research
pub_type: 杂志文章,评审
doi:10.1016/j.envres.2019.108637
更新日期:2019-10-01 00:00:00
abstract:BACKGROUND:Extracellular vesicles (EVs) represent a plausible molecular mechanism linking particulate matter (PM) inhalation to its systemic effects. Microvesicles (MVs) are released from many cell types in response to various stimuli. Increased body mass index (BMI) could modify the response to PM exposure due to enha...
journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/j.envres.2017.02.014
更新日期:2017-05-01 00:00:00
abstract::The results of chemical analysis of PM(10) atmospheric dust samples collected between July 2001 and June 2002 in rural and urban background monitoring stations in Huelva (South-western Spain) are reported. In order to identify the sources and quantify their contribution to PM(10), principal component analysis and rece...
journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/j.envres.2006.06.011
更新日期:2007-03-01 00:00:00
abstract::Several studies show that most women do not consume enough fish during pregnancy (and afterward) to derive the maximum health benefits for themselves and their babies, according to the USDA guidelines. We engaged in a two-part study to better understand what might be done to encourage women of childbearing age to eat ...
journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/j.envres.2014.08.027
更新日期:2014-11-01 00:00:00
abstract::The growing human population concentrated in urban areas lead to the increase of road traffic and artificial areas, consequently enhancing air pollution and urban heat island effects, among others. These environmental changes affect citizen's health, causing a high number of premature deaths, with considerable social ...
journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/j.envres.2017.10.006
更新日期:2018-01-01 00:00:00
abstract::Lead levels (Pb) have been linked to both hyper- and hypo-reactivity of hypothalamic-pituitary-adrenal axis (HPA) axis to acute stress in animals and humans. Similarly, allostatic load (AL), the 'wear and tear' of chronic stress, is associated with inadequate HPA axis activity. We examined whether Pb levels would be a...
journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/j.envres.2017.01.012
更新日期:2017-04-01 00:00:00
abstract::No nationwide study has ever measured polychlorinated biphenyl (PCB) and organochlorine pesticide (OCP) body burden in Canadians aged 65 years and over. The objective of this study was to determine plasma concentrations of PCB congeners and OCPs in participants from a sub-cohort of the Canadian Study of Health and Agi...
journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/j.envres.2011.09.017
更新日期:2011-11-01 00:00:00
abstract::Lactating female members and spouses of male members of the New York State Angler Cohort who agreed to provide breast milk samples were the subjects of this study. Questionnaires were provided to participants focusing on Lake Ontario fish consumption, reproductive history, and lactation history. Milk samples were anal...
journal_title:Environmental research
pub_type: 杂志文章
doi:10.1006/enrs.1998.3939
更新日期:1999-02-01 00:00:00
abstract::During the 1920's and 1930's, a Niagara County, New York residential community, Belden Center, developed in tandem with two adjacent toxic waste disposal sites. During the period that they were in use, both sites were classified as public health hazards. Particularly between 1944 and 1979, as toxins were deposited, ne...
journal_title:Environmental research
pub_type: 杂志文章
doi:10.1006/enrs.2000.4089
更新日期:2000-11-01 00:00:00
abstract::Although the anti-knocking agents used in Taiwan do not contain manganese, there are relatively high concentrations of the element in diesel fuel. As such, there have been many concerns about the impact of exposure to diesel fuels on health. This study was conducted in Taiwan to investigate the relationship between th...
journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/j.envres.2011.01.001
更新日期:2011-02-01 00:00:00
abstract:BACKGROUND:Prenatal exposure to perfluoralkyl substances (PFASs) has been reported to be associated with immunosuppression in early childhood, but with contradictory findings related to atopic and lung diseases. AIM:We aimed to determine if prenatal exposure to PFASs is associated with asthma or other allergic disease...
journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/j.envres.2017.10.012
更新日期:2018-01-01 00:00:00
abstract::It has been pointed out that, while an ecological study cannot determine whether radon causes lung cancer, it can test the validity of a linear-no threshold relationship between them. The linear-no threshold theory predicts a substantial positive correlation between the average radon exposure in various counties and t...
journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/s0013-9351(05)80119-7
更新日期:1990-12-01 00:00:00
abstract:BACKGROUND:Human biomonitoring studies have demonstrated decreasing concentrations of many persistent organic pollutants (POPs) in years after emission peaks. OBJECTIVES:To describe time trends of POPs in blood using four cross-sectional samples of 30 year olds from Tromsø, Norway across 1986-2007, and to compare the ...
journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/j.envres.2019.02.047
更新日期:2019-05-01 00:00:00
abstract::Phthalates are potentially involved in the development of type 2 diabetes mellitus. In a cohort of 123 obese subjects, 10 phthalate metabolites were analyzed. An oral glucose tolerance test was performed and various estimates of insulin resistance and beta-cell function were calculated. After adjustment for age, physi...
journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/j.envres.2015.01.010
更新日期:2015-02-01 00:00:00
abstract::Methylmercury (MeHg) is the most bioavailable and toxic form of the globally distributed pollutant Hg. Organisms of higher trophic levels living in aquatic ecosystems have potentially higher concentrations of MeHg. In this work, we analysed both MeHg and inorganic Mercury (Hg(II)) concentrations from dorsal feathers o...
journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/j.envres.2020.109526
更新日期:2020-07-01 00:00:00
abstract::The proliferative response to beryllium chloride of cells in a population of human lung fibroblasts was quantitatively assessed using time-lapse cinematography. A dose of 0.02 microgram Be/ml, known to decrease the growth rate of fibroblasts, affects an estimated 75% of the cells in the population, increasing their in...
journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/0013-9351(83)90163-9
更新日期:1983-02-01 00:00:00
abstract::The relationship between external exposure and internal doses of polycyclic aromatic hydrocarbons (PAHs) has not been established for people living in industrial areas. This study was carried out to estimate the relationship between particle-phase PAH exposure and urinary 1-hydroxypyrene (1-OHP) levels among the adult...
journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/j.envres.2014.10.007
更新日期:2015-01-01 00:00:00
abstract::The presence and accumulation of plastic waste into the marine environment are well known environmental issues. Microplastics (MPs) end up in sea waters and, due to their hydrophobicity and high surface/volume ratio, POPs tend to sorb and accumulate to their surface. The supralittoral amphipod Talitrus saltator (T. sa...
journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/j.envres.2018.07.030
更新日期:2018-11-01 00:00:00
abstract::Commercial and sport-caught fish provide a healthy source of dietary protein, omega-3 fatty acids, and other micronutrients. Regular fish consumption has been associated with decreased risk of heart disease and health professionals encourage adults to include fish in their weekly diets. However, fish harvested from co...
journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/j.envres.2009.09.008
更新日期:2010-01-01 00:00:00
abstract::Volcanic ash samples from four Mount St. Helens' volcanic eruptions were subjected to mineralogical, analytical, and hemolytic studies in order to evaluate their potential for cytotoxicity and fibrogenicity. Plagioclase minerals constituted the major component of the ash with free crystalline silica concentrations ran...
journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/0013-9351(83)90220-7
更新日期:1983-04-01 00:00:00
abstract::Natural-occurring minerals representative of six silicate classes were examined for their influence on interferon induction by influenza virus in Rhesus monkey kidney (LLC-MK2) cell monolayers. Minerals within the classes nesosilicate, sorosilicate, cyclosilicate, and inosilicate exhibited either little or marked (50%...
journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/s0013-9351(87)80040-3
更新日期:1987-08-01 00:00:00
abstract:BACKGROUND:Pesticides, especially organophosphorus pesticides such as chlorpyrifos (CPF), play an important role in modern agriculture. Studies have shown that pesticide residues are an important cause of male reproductive injury in mammal. AIM:The aim of this study was to evaluate the reproductive damage caused by CP...
journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/j.envres.2020.109785
更新日期:2020-09-01 00:00:00
abstract::We investigated the serum concentrations of two brominated flame retardants (BFRs) - polybrominated diphenyl ethers (PBDEs) and hexabromocyclododecane (HBCDD) -in 59 women aged between 23 and 42 from the United Kingdom. We also collected demographic data, including age, bodyweight and height in order to test for assoc...
journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/j.envres.2019.108631
更新日期:2019-10-01 00:00:00
abstract:BACKGROUND:There is evidence that adult lead exposure increases cancer risk. IARC has classified lead as a 'probable' carcinogen, primarily based on stomach and lung cancer associations. METHODS:We studied mortality among men in a lead surveillance program in 11 states,. categorized by their highest blood lead (BL) te...
journal_title:Environmental research
pub_type: 杂志文章,多中心研究
doi:10.1016/j.envres.2014.03.008
更新日期:2014-07-01 00:00:00