Abstract:
:Complex mixture exposures, such as those associated with water sources, are an important issue in health risk assessment. This study assessed the cytotoxicity of chemical mixtures extracted from water sources in regions of the Huai River Basin with high cancer incidences and built statistical models of cytotoxicity based on pollution profiles that were measured with gas chromatography-mass spectrometry (GC-MS). Both surface and ground waters were collected from rural water sources of Shenqiu County, Henan Province of China from 2008 to 2011 and extracted with XAD-2 resigns. Cytotoxicity was evaluated with Chinese hamster ovary K1 (CHO-K1) cells and compared against the pollution profiles of the extracts. IC50 of water samples ranged from 0.023 to 0.338L-eq/mL. The pollutants in waters determined by GC-MS are complex and some of the compounds that contributed to cytotoxicity lack toxicity data. A partial least squares (PLS) regression model of cytotoxicity was built based on linear aggregation of predictor variables (i.e., peaks for single compounds in the gas chromatograms). The PLS model contains 2 PLS factors extracted from 141 variables. The model was validated internally with training data permutation and externally with a test sample. The model explained 92% of the cytotoxicity in the training samples and 40% in the test sample. This approach provides a general, rapid method for relating water toxicity to GC-MS chromatograms and for predicting the compounds that contribute most to toxicity.
journal_name
Environ Resjournal_title
Environmental researchauthors
Tian D,Zheng W,He G,Zheng Y,Andersen ME,Tan H,Qu Wdoi
10.1016/j.envres.2014.12.027subject
Has Abstractpub_date
2015-02-01 00:00:00pages
391-7eissn
0013-9351issn
1096-0953pii
S0013-9351(14)00478-2journal_volume
137pub_type
杂志文章abstract::Long-Evans rats, 4-6 weeks of age, were given access to 0, 1, 10, or 100 ppm sodium chlorite in deionized water ad libitum as drinking water. Males were exposed 56 days, and females for 14 days prior to breeding and throughout the 10-day breeding period. Males were evaluated for sperm parameters and reproductive tract...
journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/s0013-9351(87)80025-7
更新日期:1987-02-01 00:00:00
abstract::Cigarette smoke and hydrocortisone acetate (HCA) induce marked abnormalities in lungs of C57BL/6J male mice. In many pulmonary regions of smoke-exposed, HCA-treated animals, alveoli were highly congested with surfactant and flocculent material. In addition, prominent alveolar collapse and septal hypertrophy were commo...
journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/0013-9351(83)90074-9
更新日期:1983-06-01 00:00:00
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更新日期:2020-01-01 00:00:00
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journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/j.envres.2007.10.009
更新日期:2008-02-01 00:00:00
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journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/j.envres.2017.02.034
更新日期:2017-05-01 00:00:00
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journal_title:Environmental research
pub_type: 杂志文章
doi:10.1006/enrs.2001.4317
更新日期:2002-01-01 00:00:00
abstract:OBJECTIVES:To evaluate the effect of short-term exposure to air pollutants on inflammation-sensitive biomarkers in apparently healthy individuals. METHODS:We enrolled all participants from The Tel-Aviv Sourasky Medical Center inflammation survey held between 2003 and 2006, excluding participants with an acute or chron...
journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/j.envres.2007.08.006
更新日期:2008-01-01 00:00:00
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journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/j.envres.2019.01.023
更新日期:2019-04-01 00:00:00
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journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/s0013-9351(86)80006-8
更新日期:1986-02-01 00:00:00
abstract::During the 1920's and 1930's, a Niagara County, New York residential community, Belden Center, developed in tandem with two adjacent toxic waste disposal sites. During the period that they were in use, both sites were classified as public health hazards. Particularly between 1944 and 1979, as toxins were deposited, ne...
journal_title:Environmental research
pub_type: 杂志文章
doi:10.1006/enrs.2000.4089
更新日期:2000-11-01 00:00:00
abstract::Little evidence exists about the effects of long-term exposure to ambient air pollution on metabolic syndrome (MetS). This study aimed to determine the association between long-term ambient air pollution and MetS in China. A total of 15,477 adults who participated in the 33 Communities Chinese Health Study (33CCHS) in...
journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/j.envres.2018.02.029
更新日期:2018-07-01 00:00:00
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journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/j.envres.2020.110200
更新日期:2020-12-01 00:00:00
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journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/j.envres.2017.01.010
更新日期:2017-04-01 00:00:00
abstract::Humans exposed to methylmercury (MeHg) can suffer from adverse health impacts, e.g., serious neurological damage; however, fish is also a good source of omega-3 fish oils which promotes infants' neurological development. Because eating fish is the primary mechanism of MeHg exposure, federal and state agencies issue fi...
journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/j.envres.2013.08.012
更新日期:2013-10-01 00:00:00
abstract::A pilot investigation had shown that 88 people living within 2.4 km of a waste chemical disposal and oil-reprocessing facility which operated from 1966 to 1983 had reduced neurobehavioral performance compared to 66 regional referents. A geographic model of dispersal predicted less effect with greater distance from the...
journal_title:Environmental research
pub_type: 杂志文章
doi:10.1006/enrs.1998.3971
更新日期:1999-08-01 00:00:00
abstract::This study was undertaken to determine whether home remediation effectively reduced indoor lead levels in Broken Hill, a long-established silver-lead-zinc mining town in outback Australia. A before-after study of the effect of home remediation on indoor lead levels was embedded into a randomized controlled trial of th...
journal_title:Environmental research
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.envres.2005.06.007
更新日期:2006-02-01 00:00:00
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journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/j.envres.2017.06.036
更新日期:2017-10-01 00:00:00
abstract::Polycyclic aromatic hydrocarbons (PAHs) and phthalic acid esters (PAEs) which are structurally featured with one or more aromatic skeletons are often regarded as two important groups of organic pollutants due to the widespread distribution and notorious toxic effects in soils. Relative to the great number of structura...
journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/j.envres.2019.108838
更新日期:2019-12-01 00:00:00
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journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/j.envres.2013.05.007
更新日期:2013-10-01 00:00:00
abstract::Our study investigated a large variety of per- and polyfluoroalkyl substances (PFASs) in house dust collected from Guangzhou, South China during 2015-2018. The perfluorobutane sulfonic acid (PFBS) exhibited the highest median concentration (17.6 ng/g), followed by linear perfluorooctanoic acid (L-PFOA; 4.8 ng/g), line...
journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/j.envres.2020.110243
更新日期:2021-01-01 00:00:00
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journal_title:Environmental research
pub_type: 杂志文章,多中心研究
doi:10.1016/j.envres.2014.03.008
更新日期:2014-07-01 00:00:00
abstract::The relationship of inorganic arsenic exposure through drinking water and total urinary arsenic excretion in a nonoccupationally exposed population was evaluated in a cross-sectional study in three mayor cities of Chile (Antofagasta, Santiago, and Temuco). A total of 756 individuals in three population strata (elderly...
journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/j.envres.2005.02.007
更新日期:2005-06-01 00:00:00
abstract::Day-old Japanese quail were fed purified diets containing either 0.2 (control), 5.4, or 16.2 ppm lead as the acetate with either 25 (deficient) or 100 ppm (adequate control) iron for 2 weeks. Iron deficiency caused decreases in hemoglobin, iron, and manganese in the liver, and hepatic RNA synthesis. Iron deficiency al...
journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/0013-9351(84)90030-6
更新日期:1984-04-01 00:00:00
abstract:BACKGROUND:Carbamate pesticides exposure have been linked with adverse health effects during developmental period. Based on 377 mother-child pairs from Sheyang Mini Birth Cohort Study, the present study aimed to assess carbofuranphenol exposure of three-year-old children and explore the associations between prenatal or...
journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/j.envres.2019.108590
更新日期:2019-10-01 00:00:00
abstract::The effect of intratracheal administration of fly ash, its benzene-extracted residue and the benzene extract has been studied on the activities of hepatic mixed-function oxidases in the rat. Fly ash and its fractions significantly increased the levels of cytochrome P-450, cytochrome b5, cytochrome b5 reductase, NADPH-...
journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/s0013-9351(87)80231-1
更新日期:1987-12-01 00:00:00
abstract::Climate change is one of the biggest and most urgent challenges for the 21st century. Rising average temperatures and ocean levels, altered precipitation patterns and increased occurrence of extreme weather events affect not only the global landscape and ecosystem, but also human health. Multiple environmental factors...
journal_title:Environmental research
pub_type: 杂志文章,评审
doi:10.1016/j.envres.2019.108637
更新日期:2019-10-01 00:00:00
abstract::Bisphenol A (BPA) and its main substitute, bisphenol S (BPS), are synthetic organic compounds found in various consumer products, in particular food and beverage containers. Numerous reports have shown a link between bisphenol exposure, human contamination and increased health problems. BPA, BPS and their metabolites ...
journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/j.envres.2020.110336
更新日期:2020-10-20 00:00:00
abstract:BACKGROUND:Human biomonitoring studies have demonstrated decreasing concentrations of many persistent organic pollutants (POPs) in years after emission peaks. OBJECTIVES:To describe time trends of POPs in blood using four cross-sectional samples of 30 year olds from Tromsø, Norway across 1986-2007, and to compare the ...
journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/j.envres.2019.02.047
更新日期:2019-05-01 00:00:00
abstract::In whole animals, ozone acutely impairs pulmonary function, an effect which may be mediated by eicosanoids. This study determined if the lung itself, separated from blood components and the CNS, responds to ozone with increased eicosanoid production and decreased function. Wistar rat lungs were placed in a negatively ...
journal_title:Environmental research
pub_type: 杂志文章
doi:10.1006/enrs.1994.1054
更新日期:1994-08-01 00:00:00
abstract:OBJECTIVE:Longitudinal studies on neurobehavioral development in relation to prenatal and postnatal exposure to phthalates in school-age children and adolescents are limited. We investigated the association of prenatal and childhood phthalate exposure with the development of behavioral syndromes in 8-14-year-old childr...
journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/j.envres.2019.02.029
更新日期:2019-05-01 00:00:00