Association of urinary cadmium and myocardial infarction.

Abstract:

:We conducted a cross-sectional analysis of individuals 45-79 years old in the National Health and Nutrition Examination Survey III (1988-1994) (NHANES III). Myocardial infarction was determined by electrocardiogram (ECG). Our sample included 4912 participants, which when weighted represented 52,234,055 Americans. We performed adjusted logistic regressions with the Framingham risk score, pack-years of smoking, race-ethnicity, and family history of heart attack, and diabetes as covariates. Urinary cadmium >or= 0.88 microg/g creatinine had an odds ratio of 1.86 (95% CI 1.26-2.75) compared to urinary cadmium <0.43 microg/g creatinine. This result supports the hypothesis that cadmium is associated with coronary heart disease. When logistic regressions were done by gender, women, but not men, showed a significant association of urinary cadmium with myocardial infarction. Women with urinary cadmium >or= 0.88 microg/g creatinine had an odds ratio of 1.80 (95% CI 1.06-3.04) compared to urinary cadmium <0.43 microg/g creatinine. When the analysis was restricted to never smokers (N=2187) urinary cadmium >or= 0.88 microg/g creatinine had an odds ratio of 1.85 (95% CI 1.10-3.14) compared to urinary cadmium <0.43 microg/g creatinine.

journal_name

Environ Res

journal_title

Environmental research

authors

Everett CJ,Frithsen IL

doi

10.1016/j.envres.2007.10.009

subject

Has Abstract

pub_date

2008-02-01 00:00:00

pages

284-6

issue

2

eissn

0013-9351

issn

1096-0953

pii

S0013-9351(07)00226-5

journal_volume

106

pub_type

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