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Urinary concentrations of bisphenol A in an urban minority birth cohort in New York City, prenatal through age 7 years.

Abstract：

BACKGROUND:Despite growing concern over potential health effects associated with exposures to the endocrine disruptor, bisphenol A (BPA), insufficient information is available on determinants of BPA concentrations among minority populations in the US. OBJECTIVES:To describe concentrations and predictors of BPA in an inner-city longitudinal birth cohort. METHODS:We analyzed spot urines for total BPA collected during pregnancy and child ages 3, 5, and 7 years from African Americans and Dominicans (n=568) enrolled in the Columbia Center for Children's Environmental Health birth cohort and residing in Northern Manhattan and the South Bronx. Adjusting for specific gravity, generalized estimating equations were used to compare BPA concentrations across paired samples and linear regression analyses were used to determine relationships between BPA, season of sample collection, socio-demographic variables and urinary concentrations of phthalate metabolites. RESULTS:BPA was detected in ≥ 94% of samples. Prenatal concentrations were significantly lower than postnatal concentrations. Geometric means were higher among African Americans compared to Dominicans in prenatal (p=0.008), 5 year (p<0.001) and 7 year (p=0.017) samples. Geometric means at 5 and 7 years were higher (p=0.021, p=0.041 respectively) for children of mothers never married compared to mothers ever married at enrollment. BPA concentrations were correlated with phthalate metabolite concentrations at prenatal, 3, 5 and 7 years (p-values <0.05). Postnatal BPA concentrations were higher in samples collected during the summer. CONCLUSIONS:This study shows widespread BPA exposure in an inner-city minority population. BPA concentration variations were associated with socio-demographic characteristics and other xenobiotics.

journal_name

Environ Res

journal_title

Environmental research

authors

Hoepner LA,Whyatt RM,Just AC,Calafat AM,Perera FP,Rundle AG

doi

10.1016/j.envres.2012.12.003

subject

Has Abstract

pub_date

2013-04-01 00:00:00

pages

38-44

eissn

0013-9351

issn

1096-0953

pii

S0013-9351(12)00323-4

journal_volume

122

pub_type

杂志文章

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Urinary concentrations of bisphenol A in an urban minority birth cohort in New York City, prenatal through age 7 years.