Abstract:
BACKGROUND:Dairy working increases the prevalence of lower airway respiratory diseases, especially COPD and asthma. Epidemiological studies have reported that chronic inhalation of organic dusts released during specific daily tasks could represent a major risk factor for development of these pathologies in dairy workers. Knowledge on size, nature and biological activity of such organic dusts remain however limited. OBJECTIVE:To compare size distribution, microbial composition and cellular effects of dusts liberated by the spreading of straw bedding in five French dairy farms located in Brittany. RESULTS:Mechanized distribution of straw bedding generated a cloud of inhalable dusts in the five dairy farms' barns. Thoracic particles having a 3-7.5µm size constituted 58.9-68.3% of these dusts. Analyses of thoracic dusts by next generation sequencing showed that the microbial dust composition differed between the five French farms, although Actinobacteria, Bacteroidetes, Firmicutes and Proteobacteria represent more than 97.5% of the bacterial phyla detected in each sample. Several bacteria genera comprising of human pathogenic species, such as Pseudomonas, Staphylococcus, Thermoactinomyces or Saccharopolyspora were identified. Cladosporium and Alternaria fungal genera, which are potent environmental determinants of respiratory symptoms, were detected in dusts collected in the five farms and their levels reached 15.5-51.1% and 9-24.7% of assignable fungal sequences in each sample, respectively. Finally, all dust samples significantly and strongly increased the expression of the pro-inflammatory TNF-α, IL-1β, IL-6 and IL-8 cytokines at both mRNA and protein levels in human monocyte-derived macrophages. Their effects were dose-dependent and detectable from 1µg/ml. The intensity of the macrophage responses however differed according to the samples. CONCLUSIONS:Our results strengthen the hypothesis that organic dusts released during the distribution of straw bedding are mainly constituted of thoracic particles which are small enough to deposit on lower bronchial epithelium of dairy farmers and induce inflammation.
journal_name
Environ Resjournal_title
Environmental researchauthors
Pfister H,Morzadec C,Le Cann P,Madec L,Lecureur V,Chouvet M,Jouneau S,Vernhet Ldoi
10.1016/j.envres.2017.07.025subject
Has Abstractpub_date
2017-10-01 00:00:00pages
691-702eissn
0013-9351issn
1096-0953pii
S0013-9351(17)30689-8journal_volume
158pub_type
杂志文章abstract:BACKGROUND:According to the WHO, low birth weight (<2500 gr) is a primary maternal health indicator as the cause of multiple morbi-mortality in the short and long-term. It is known that air pollution from road traffic (PM10, NO2) and O3 have an important impact on low birth weight (LBW), but there are few studies of th...
journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/j.envres.2019.01.030
更新日期:2019-04-01 00:00:00
abstract::The MXene-based transition metal oxide composite is a potential candidate for photocatalysts. Rod-like pseudohexagonal phase Nb2O5/Nb2CTx composites were synthesized by a simple hydrothermal oxidation of 2D layered Nb2CTx. The Nb2O5/Nb2CTx composites show superior photocatalytic activity for 98.5% of degradation of Rh...
journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/j.envres.2020.110587
更新日期:2021-02-01 00:00:00
abstract::The Bis(2-ethylhexyl)phthalate (DEHP), a widespread plasticizer, is considered an endocrine disrupting chemical with main toxicological effects on reproductive and metabolic systems. Human biomonitoring (HBM) studies are promoted to evaluate the background exposure levels. In the frame of LIFE PERSUADED project, the H...
journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/j.envres.2020.109428
更新日期:2020-06-01 00:00:00
abstract:BACKGROUND:Exposure to PM2.5 (fine particulate matter journal_title:Environmental research pub_type: 杂志文章 doi:10.1016/j.envres.2017.11.050 更新日期:2018-02-01 00:00:00
abstract:BACKGROUND:Heatwaves form a serious public health threat, especially for vulnerable groups. Interventions such as active outreach programs, exposure reduction measures and monitoring and mapping of at-risk groups are increasingly implemented across the world but little is known about their effect. OBJECTIVES:To assess...
journal_title:Environmental research
pub_type: 杂志文章,评审
doi:10.1016/j.envres.2018.05.021
更新日期:2018-10-01 00:00:00
abstract::In 1976, the New York Giants professional football team relocated to the newly constructed Meadowlands Sports Complex (MSC) in East Rutherford, NJ. Between 1980 and 1987 four team members developed cancer: one case each of non-Hodgkin's lymphoma, glioblastoma, angiosarcoma, and Hodgkin's disease. Because the surroundi...
journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/s0013-9351(05)80003-9
更新日期:1991-12-01 00:00:00
abstract::Day-old Japanese quail were fed purified diets containing either 0.2 (control), 5.4, or 16.2 ppm lead as the acetate with either 25 (deficient) or 100 ppm (adequate control) iron for 2 weeks. Iron deficiency caused decreases in hemoglobin, iron, and manganese in the liver, and hepatic RNA synthesis. Iron deficiency al...
journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/0013-9351(84)90030-6
更新日期:1984-04-01 00:00:00
abstract::An iterative scheme of short-term bacterial mutagenesis assays and multidimensional liquid chromatographic methods was used to isolate mutagens from a neutral fraction of a complex carcinogenic tar formed as a by-product of coal gasification. Mutagens in the complementary reversed- and normal-phase liquid chromatograp...
journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/s0013-9351(86)80135-9
更新日期:1986-12-01 00:00:00
abstract::The influence of cadmium (Cd) body burden on mortality remains controversial. Excess mortality and the dose-response relationship between mortality and urinary cadmium excretion were investigated in this study among environmentally exposed subjects. A 15-year follow-up study was carried out on 3119 inhabitants (1403 m...
journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/j.envres.2005.08.014
更新日期:2006-03-01 00:00:00
abstract:BACKGROUND:Healthcare workers (HCWs) are highly exposed to SARS-CoV-2 infection given their specific tasks. The IgG-IgM serological assay has demonstrated good accuracy in early detection in symptomatic patients, but its role in the diagnosis of asymptomatic patients is uncertain. The aim of our study was to assess IgM...
journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/j.envres.2021.110793
更新日期:2021-01-25 00:00:00
abstract::Minamata disease is methylmercury poisoning from consuming fish and shellfish contaminated by industrial waste. The polluted seafood was widely consumed in the area around Minamata, but many individuals were never examined for or classified as having Minamata disease. Following the determination of the Supreme Court o...
journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/j.envres.2007.05.012
更新日期:2008-05-01 00:00:00
abstract::Mercury (Hg) has been shown to have immunotoxic effects and to influence the severity of infection. However, the impact of infection on the normal Hg homeostasis in different target organs involved in the disease process has not been studied. In this study, Hg was measured through inductively coupled plasma-mass spect...
journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/j.envres.2007.08.002
更新日期:2008-02-01 00:00:00
abstract::Vitamin D metabolism in primates with chronic exposure to cadmium was studied in relation to Itai-Itai disease. In a series of experiments, crab-eating monkeys were fed cadmium-contaminated rice (1.33 micrograms Cd/g) or a diet containing 3 micrograms/g cadmium chloride for 6 years. These treatments had no effect on t...
journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/s0013-9351(88)80058-6
更新日期:1988-06-01 00:00:00
abstract::The effects of methylmercury administration on adenosine 3',5'-cyclic monophosphate (cAMP)-dependent protein kinase (protein kinase A) and protein kinase C were investigated by determining their second messenger bindings ([3H]cAMP binding for protein kinase A and [3H]PDBu for protein kinase C) and enzymatic activities...
journal_title:Environmental research
pub_type: 杂志文章
doi:10.1006/enrs.1993.1146
更新日期:1993-11-01 00:00:00
abstract:BACKGROUND:Immigrant women are often identified as being particularly vulnerable to environmental exposures and health effects. The availability of biomonitoring data on newcomers is limited, thus, presenting a challenge to public health practitioners in the identification of priorities for intervention. OBJECTIVES:In...
journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/j.envres.2016.12.013
更新日期:2017-04-01 00:00:00
abstract::Cigarette smoke and hydrocortisone acetate (HCA) induce marked abnormalities in lungs of C57BL/6J male mice. In many pulmonary regions of smoke-exposed, HCA-treated animals, alveoli were highly congested with surfactant and flocculent material. In addition, prominent alveolar collapse and septal hypertrophy were commo...
journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/0013-9351(83)90074-9
更新日期:1983-06-01 00:00:00
abstract::The purpose of this investigation was to examine the relationship between airway responsiveness and the permeability of histamine through the airways in conscious sheep after exposure to ozone (O3). Airway responsiveness was assessed by measuring the change from baseline in mean pulmonary flow resistance following a c...
journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/0013-9351(84)90080-x
更新日期:1984-06-01 00:00:00
abstract::Although the commercial synthesis of polychlorinated biphenyls (PCBs) has been banned in the United States for several decades, they are persistent in the environment with exposure mainly being through diet. The biologic and toxic effects of PCBs and their metabolites are due in part to their ability to interact with ...
journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/j.envres.2004.05.013
更新日期:2005-05-01 00:00:00
abstract::A nationwide survey of indoor air quality in Japan was conducted using four types of diffusive samplers. Gaseous chemical compounds such as carbonyls, volatile organic compounds (VOC), acid gases, basic gases, and ozone were measured in indoor and outdoor air of 602 houses throughout Japan in winter and summer. Four k...
journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/j.envres.2014.12.005
更新日期:2015-02-01 00:00:00
abstract::Environmental exposure to cadmium (Cd) is known to induce oxidative stress, a state of imbalance between the production of reactive oxygen species (ROS) and the ability to detoxify them, in adults. However, data are lacking on potential effects in early-life. We evaluated urinary concentrations of 8-oxo-7,8-dihydro-2'...
journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/j.envres.2011.11.012
更新日期:2012-01-01 00:00:00
abstract::Effects of fine volcanic ash aerosol on pulmonary mechanical properties of awake guinea pigs were evaluated during exposure by inhalation. Ash penetration into the lung as well as tissue response to ash were determined by transmission electron microscopy. The reactivity of airway epithelial irritant receptors followin...
journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/0013-9351(85)90020-9
更新日期:1985-02-01 00:00:00
abstract:BACKGROUND:Ambient air pollution has been associated with acute cardiovascular events; however, the underlying mechanisms remain incompletely understood. We aimed to examine the impacts of ambient air pollutants on cardiac ventricular repolarization in a highly polluted urban region. METHODS:Seventy-three healthy non-...
journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/j.envres.2019.01.023
更新日期:2019-04-01 00:00:00
abstract::Microplastics (MPs) in the Arctic have raised increasing concern, but knowledge on MP contamination in benthic organisms from Arctic shelf regions, e.g., the Chukchi Sea is still limited. Therefore, the present study investigated the occurrence, characteristics, sources, and environmental implications of MPs in the th...
journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/j.envres.2020.110326
更新日期:2021-01-01 00:00:00
abstract:BACKGROUND:Extremes in water availability, either exceptionally wet or dry conditions, can damage crops and may detrimentally affect the livelihood and well-being of people engaged in agriculture. We estimated the effect of water availability on suicide in rural India, a context where the majority of households are dep...
journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/j.envres.2020.109969
更新日期:2020-11-01 00:00:00
abstract::Minamata disease is methyl mercury intoxication from fish contaminated by a chemical factory in Minamata city. Based on the results of our regional survey, cardinal clinical features of the disease were clarified by a multivariant analysis of all symptoms in inhabitants in the polluted area. The clinical features were...
journal_title:Environmental research
pub_type: 杂志文章,评审
doi:10.1006/enrs.1993.1137
更新日期:1993-10-01 00:00:00
abstract::To determine pulmonary deposition and clearance of inhaled volcanic ash, rats received a single 60-min, nose-only exposure to neutron-activated ash. Over a period of 128 days after exposure, the rats were sacrificed in groups of five animals. Lungs were analyzed for the radionuclide tracers 46Sc, 59Fe, and 60Co by gam...
journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/0013-9351(84)90129-4
更新日期:1984-10-01 00:00:00
abstract::Mercury content of twelve podzols from NW Spain was studied to elucidate the main soil properties involved in the Hg accumulation of these soils. The highest average Hg concentrations (HgT) were found in the Bh and Bs horizons (64 and 105 μg kg-1), whereas the lowest occurred in the E horizons (15 μg kg-1). Moderate v...
journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/j.envres.2020.110552
更新日期:2021-02-01 00:00:00
abstract::Chlorine is a reactive gas used by humanity for over two centuries. Exposure to chlorine has occurred in a number of situations, including as a chemical warfare agent, in industrial and domestic exposures, and as a result of accidents and spills. The toxicology of chlorine is related almost entirely to effects in the ...
journal_title:Environmental research
pub_type: 杂志文章,评审
doi:10.1006/enrs.2000.4110
更新日期:2001-02-01 00:00:00
abstract::Cisitu is a small-scale gold mining village in Indonesia. Mercury (Hg) is used to extract gold from ore, heavily polluting air, soil, fish and rice paddy fields with Hg. Rice in Cisitu is burdened with mercury. The main staple food of the inhabitants of Cisitu is this polluted rice. Villagers were concerned that the s...
journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/j.envres.2016.04.007
更新日期:2016-08-01 00:00:00
abstract::The aim of the study was to assess the physicochemical properties of compost made of municipal sewage sludge from selected Municipal Sewage Treatment Plant. Content of basic macroelements and heavy metals (Zn, Cu, Cr, Cd, Ni, Pb, Hg, Mg, Ca, N, P, K, Na) and their fractions was determined by means of BCR method. Based...
journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/j.envres.2017.02.035
更新日期:2017-07-01 00:00:00