Abstract：
:Although the commercial synthesis of polychlorinated biphenyls (PCBs) has been banned in the United States for several decades, they are persistent in the environment with exposure mainly being through diet. The biologic and toxic effects of PCBs and their metabolites are due in part to their ability to interact with several cellular and nuclear receptors, thereby altering signaling pathways and gene transcription. These effects include endocrine modulation and disruption. Therefore, the natural history of cancer in tissues expressing these receptors may be modulated by PCB congeners, which are known to have estrogenic, antiestrogenic, and other hormonal effects. Several frameworks for grouping PCB congeners based on these interactions have been proposed. We conducted a hospital-based, case-control pilot study of 58 prostate cancer cases and 99 controls to evaluate the association between the proposed PCB groupings and the risk of prostate cancer. Serum samples were analyzed for a total of 30 PCBs. In multivariate analyses, the odds of prostate cancer among men with the highest concentrations of moderately chlorinated PCBs or PCBs with phenobarbital-like activities (constitutively active receptor (CAR) agonists) was over two times that among men with the lowest concentrations. Increasing trends in risk across the concentration levels were also observed. These results suggest that a higher burden of PCBs that are CAR agonists may be positively associated with an increased risk of prostate cancer and they encourage further research in this area.
journal_name
Environ Resjournal_title
Environmental researchauthors
Ritchie JM,Vial SL,Fuortes LJ,Robertson LW,Guo H,Reedy VE,Smith EMdoi
10.1016/j.envres.2004.05.013subject
Has Abstractpub_date
2005-05-01 00:00:00pages
104-13issue
1eissn
0013-9351issn
1096-0953pii
S0013-9351(04)00098-2journal_volume
98pub_type
杂志文章abstract：:Excessive nitrogen (N) input is one of the most important causative factors of lake eutrophication, which has aroused increasing public attention in past decades. Estrogen contamination is also an increasing environmental problem in aquatic systems around the world. Although both substances usually co-exist in aquatic...
journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/j.envres.2019.108769
更新日期：2019-12-01 00:00:00
abstract：:Daily emergency room (ER) visits for all respiratory (ICD-9 460-519) and asthma (ICD-9 493) were compared with daily sulfur dioxide (SO2), ozone (O3), and weather variables over the period 1998-2000 in Portland, Maine (population 248,000), and 1996-2000 in Manchester, New Hampshire (population 176,000). Seasonal varia...
journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/j.envres.2004.07.010
更新日期：2005-03-01 00:00:00
abstract：OBJECTIVES:Uranium miners are chronically exposed to radon and its progeny, which are known to cause lung cancer and may be associated with leukemia. This study was undertaken to evaluate risk of non-lung solid cancers among uranium miners in Příbram region, Czech Republic. METHODS:A retrospective stratified case-coho...
journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/j.envres.2011.01.008
更新日期：2011-04-01 00:00:00
abstract：BACKGROUND:The association between short-term exposure to air pollution and morbidity of COPD and asthma has been observed in many studies. However, there is a lack of systematic review of the overall risk ratios in East Asian area to provide scientific evidence for health risk assessment. METHODS:A systematic literat...
journal_title：Environmental research
pub_type： 杂志文章,meta分析,评审
doi：10.1016/j.envres.2016.03.008
更新日期：2016-07-01 00:00:00
abstract：:Benzo[a]pyrene (BaP) is a useful indicator of exposure to polycyclic aromatic hydrocarbons (PAHs), airborne carcinogenic compounds. Radioimmunoassay was used to test for plasma BaP differences in 61 subjects divided into three groups based on geographic-demographic locale: urban-industrial, urban-residential, and oute...
journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/0013-9351(83)90196-2
更新日期：1983-10-01 00:00:00
abstract：BACKGROUND:Exposure to heavy metals may increase risk of kidney disease, but most studies have examined individual metals or two-way interactions. There is increasing recognition of the importance of studying exposure to metal mixtures and health outcomes. OBJECTIVES:We used Bayesian kernel machine regression (BKMR) t...
journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/j.envres.2020.110126
更新日期：2020-12-01 00:00:00
abstract：:Exposure to polycyclic aromatic hydrocarbons (PAHs) was assessed in a cohort of 394 subjects, 198 residing in three small municipalities near a new waste-to-energy (WTE) incinerator located in the Turin area, and 196 residing in neighbouring control areas in the town (of Turin). The assessment of exposure to PAHs was ...
journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/j.envres.2019.108903
更新日期：2020-02-01 00:00:00
abstract：:The expected growing population and challenges associated with globalisation will increase local food and feed demands and enhance the pressure on local and regional upland soil resources. In light of these potential future developments it is necessary to define sustainable land use and tolerable soil loss rates with ...
journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/j.envres.2017.09.020
更新日期：2018-01-01 00:00:00
abstract：OBJECTIVE:Longitudinal studies on neurobehavioral development in relation to prenatal and postnatal exposure to phthalates in school-age children and adolescents are limited. We investigated the association of prenatal and childhood phthalate exposure with the development of behavioral syndromes in 8-14-year-old childr...
journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/j.envres.2019.02.029
更新日期：2019-05-01 00:00:00
abstract：:Environmental exposures and poor sleep outcomes are known to have consequential effects on human health. This integrative review first seeks to present and synthesize existing literature investigating the relationship between exposure to various environmental factors and sleep health. We then present potential mechani...
journal_title：Environmental research
pub_type： 杂志文章,评审
doi：10.1016/j.envres.2020.110406
更新日期：2020-10-29 00:00:00
abstract：:Temperature has been related to mean differences in DNA methylation. However, heterogeneity in these associations may exist across the distribution of methylation outcomes. This study examined whether the association between three-week averaged of temperature and methylation differs across quantiles of the methylation...
journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/j.envres.2016.05.034
更新日期：2016-10-01 00:00:00
abstract：:Zika virus is transmitted by Aedes mosquitoes, especially, Ae. aegypti and Ae. albopictus. About 80% of the cases do not manifest any symptoms, and it is a self-limiting, mild viral infection. In 20% of the cases and only in fraction of those who do show the symptoms, important complications including Guillaine Barre'...
journal_title：Environmental research
pub_type： 杂志文章,评审
doi：10.1016/j.envres.2020.109868
更新日期：2020-09-01 00:00:00
abstract：BACKGROUND:Polychlorinated biphenyls (PCBs) may interact with several thyroid functions. Severe environmental pollution by PCBs has been observed in Brescia, Italy, due to the presence of a factory that produced these compounds until 1984. OBJECTIVES:We aimed to investigate the correlation between serum levels of tota...
journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/j.envres.2008.08.003
更新日期：2008-11-01 00:00:00
abstract：:The objective of the study was to determine the relationship between cadmium (Cd) intake and cadmium toxicity indicators by meta-analysis of literature data, in particular beta2-microglobulin (beta2MC), and to compare the results with the current Provisional Tolerable Weekly Intake (PTWI) set by FAO/WHO. The literatur...
journal_title：Environmental research
pub_type： 杂志文章,meta分析,评审
doi：10.1016/j.envres.2006.09.006
更新日期：2007-03-01 00:00:00
abstract：OBJECTIVES:Within a New York City (NYC) birth cohort, we assessed the associations between polycyclic aromatic hydrocarbon (PAH) and other aromatic DNA adducts and brain derived neurotrophic factor (BDNF) concentrations in umbilical cord blood, and neurodevelopment at age 2 years and whether BDNF is a mediator of the a...
journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/j.envres.2015.08.011
更新日期：2015-10-01 00:00:00
abstract：:Noise pollution is a major environmental problem due to its impact on human health and implications for other spheres of society. Since road traffic is the main source of noise pollution, the use of measurement methodologies to accurately determine the environmental noise levels to which the façades of buildings in ci...
journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/j.envres.2020.110055
更新日期：2020-12-01 00:00:00
abstract：:There is growing evidence that exposure to persistent organic pollutants (POPs) is statistically associated with incidence of cardiovascular disease (CVD) or its risk factors. Decarbromodiphenyl ether (BDE-209) is a new POP which exists extensively in human tissues, but its potential effects on CVD have so far receive...
journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/j.envres.2018.10.035
更新日期：2019-02-01 00:00:00
abstract：:Tobacco smoke-related air pollutant levels were studied in ten Finnish restaurants. Markers of tobacco smoke were measured together with other compounds typical of tobacco smoke and indoor air. The measurements were carried out at stationary sampling points in smoking and non-smoking areas of the restaurants in 2005-2...
journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/j.envres.2008.07.020
更新日期：2008-11-01 00:00:00
abstract：:The effects of several aromatic carcinogens and their noncarcinogenic analogs on the production of alpha/beta interferon by mouse embryo fibroblasts were determined. The carcinogens 2-naphthylamine and 9,10-dimethylanthracene significantly depressed alpha/beta interferon production, while their poorly or noncarcinogen...
journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/0013-9351(84)90096-3
更新日期：1984-08-01 00:00:00
abstract：BACKGROUND:Although air pollution and social stress may independently increase childhood asthma, little is known on their synergistic effect on asthma, particularly in China with high levels of stress and air pollution. OBJECTIVES:To examine associations between exposure to a combination of parental stress and air pol...
journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/j.envres.2018.04.003
更新日期：2018-08-01 00:00:00
abstract：BACKGROUND:Lead is an established toxic substance, with wide-ranging health effects, including neurodevelopmental decrements and behavioural problems, even at low levels in blood. Anecdotal reports of lead melting to make fishing sinkers in South African subsistence fishing communities prompted the conduct of an epidem...
journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/j.envres.2013.05.009
更新日期：2013-10-01 00:00:00
abstract：:Polychlorinated biphenyls (PCBs) have been suspected for some time of having adverse effects on neuropsychological functioning in humans. While there is evidence of slowing of cognitive function in children associated with exposure to PCBs, the evidence of comparable effects on adults is far less well understood. We r...
journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/j.envres.2008.10.003
更新日期：2009-01-01 00:00:00
abstract：:As part of a longitudinal investigation into mobilization of lead from the maternal skeleton during pregnancy and lactation, we have determined the daily intake of selected elements (hereafter called micronutrients) for various subjects and compared these intakes with recommended and/or published intakes, especially t...
journal_title：Environmental research
pub_type： 杂志文章
doi：10.1006/enrs.2001.4309
更新日期：2001-12-01 00:00:00
abstract：:Studies of heat-related mortality have been predominantly based on analyses of underlying cause of death as the single indicator of a population's vulnerability to high temperatures. Examination of both underlying and associated causes of death could provide a more comprehensive understanding of the population at risk...
journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/j.envres.2008.07.015
更新日期：2008-11-01 00:00:00
abstract：:Fish consumption from the Great Lakes and the St. Lawrence River has been decreasing over the last years due to advisories and increased awareness of the presence of several contaminants. Methylmercury (MeHg), a well-established neurotoxicant even at low levels of exposure, bioaccumulates to differing degrees in vario...
journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/j.envres.2003.12.007
更新日期：2004-07-01 00:00:00
abstract：BACKGROUND:Despite growing concern over potential health effects associated with exposures to the endocrine disruptor, bisphenol A (BPA), insufficient information is available on determinants of BPA concentrations among minority populations in the US. OBJECTIVES:To describe concentrations and predictors of BPA in an i...
journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/j.envres.2012.12.003
更新日期：2013-04-01 00:00:00
abstract：BACKGROUND:Allergic sensitization during childhood is a dynamic process with a substantial rate of remission. Factors influencing this process are largely unknown. METHODS:We conducted a two-year prospective study among 121 schoolchildren (mean age, 5.8 years; 64 boys). We measured urea, club cell protein (CC16), β2-m...
journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/j.envres.2017.06.009
更新日期：2017-10-01 00:00:00
abstract：:In this study, Ag3PO4/TiO2@molecular sieve (MS) ternary composites were fabricated via in-situ deposition and hydrothermal growth method for photocatalytic degradation of formaldehyde and sodium isobutyl xanthate (SIBX) under visible light irradiation. XRD, PL, UV-vis, UPS, SEM-EDS and XPS techniques were adopted to c...
journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/j.envres.2020.109984
更新日期：2020-11-01 00:00:00
abstract：BACKGROUND:A higher incidence rate (IR) of acute gastrointestinal (GI) infections associated with prenatal exposure to p,p'-DDE was suggested by the results in two studies. Given the high mortality rate due to childhood diarrhea in some countries with ongoing use of DDT, additional data on this association is relevant ...
journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/j.envres.2017.08.027
更新日期：2017-11-01 00:00:00
abstract：:Despite intense societal and scientific debates regarding glyphosate toxicity, it remains the most widely used herbicide. The primary metabolite of glyphosate, AMPA (aminomethylphosphonic acid), is the main contaminant detected in surface waters worldwide, both because of the extensive use of glyphosate and because of...
journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/j.envres.2020.109944
更新日期：2020-11-01 00:00:00
