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Effect of aromatic carcinogens and noncarcinogenic analogs on the induction of murine alpha/beta interferon.

Abstract：

:The effects of several aromatic carcinogens and their noncarcinogenic analogs on the production of alpha/beta interferon by mouse embryo fibroblasts were determined. The carcinogens 2-naphthylamine and 9,10-dimethylanthracene significantly depressed alpha/beta interferon production, while their poorly or noncarcinogenic analogs, 1-naphthylamine and anthracene, respectively, had no significant effect. Neither the carcinogen benzidine nor its poorly carcinogenic analog 3,3',5,5'-tetramethylbenzidine had any effect on alpha/beta interferon production. These data, taken together with previous findings, suggest the possibility of drawing a high correlation between the carcinogenic potential of a chemical and its effect on interferon production.

journal_name

Environ Res

journal_title

Environmental research

authors

Sonnenfeld G,Hudgens RW,Streips UN

doi

10.1016/0013-9351(84)90096-3

subject

Has Abstract

pub_date

1984-08-01 00:00:00

pages

280-6

issue

2

eissn

0013-9351

issn

1096-0953

pii

0013-9351(84)90096-3

journal_volume

34

pub_type

杂志文章

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