Abstract:
:The effects of acute NO2 exposure on antigen-specific cell-mediated lung immunity in Fischer 344 rats were evaluated. Animals were exposed for 24 hr to either room air or 5, 10, or 26 ppm NO2 before intratracheal immunization with 10(8) sheep red blood cells (SRBC). Cellular immunity was evaluated by antigen-specific lymphocyte stimulation assays of pooled lymphoid cell suspensions from either the thoracic lymph nodes or spleens. Elevated cellular immunity was observed after exposure to NO2. The ability of the 26 ppm NO2 exposure to increase cellular immunity seemed to parallel, and in some cases even exceed, that seen in control animals immunized with SRBC mixed with 2 X 10(7) heat-killed Bacillus Calmette-Guerin. These results support the theory that lung damage, and/or alterations of regulatory populations of immune cells, induced by agents such as NO2 can be responsible for the production of abnormally elevated immune responses to antigens deposited in the damaged lung.
journal_name
Environ Resjournal_title
Environmental researchauthors
Hillam RP,Bice DE,Hahn FF,Schnizlein CTdoi
10.1016/0013-9351(83)90076-2subject
Has Abstractpub_date
1983-06-01 00:00:00pages
201-11issue
1eissn
0013-9351issn
1096-0953pii
0013-9351(83)90076-2journal_volume
31pub_type
杂志文章abstract::Ciguatera fish poisoning (CFP) is one of the most devastating food-borne illnesses caused by fish consumption. Ciguatoxins (CTXs) are potent neurotoxins synthesized by the benthic microalgae Gambierdiscus spp. and Fukuyoa spp. that are transmitted to fish by grazing and predation. Despite the high incidence of CFP, af...
journal_title:Environmental research
pub_type: 杂志文章,评审
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journal_title:Environmental research
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journal_title:Environmental research
pub_type: 杂志文章,评审
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journal_title:Environmental research
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doi:10.1016/0013-9351(85)90116-1
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journal_title:Environmental research
pub_type: 杂志文章,评审
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journal_title:Environmental research
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journal_title:Environmental research
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更新日期:2020-04-01 00:00:00
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journal_title:Environmental research
pub_type: 杂志文章
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journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/j.envres.2006.10.007
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journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/j.envres.2006.11.010
更新日期:2007-10-01 00:00:00
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journal_title:Environmental research
pub_type: 杂志文章
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pub_type: 杂志文章,meta分析,评审
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更新日期:2016-07-01 00:00:00
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journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/j.envres.2006.02.002
更新日期:2006-07-01 00:00:00
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journal_title:Environmental research
pub_type: 杂志文章
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更新日期:2020-12-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/j.envres.2020.110267
更新日期:2021-01-01 00:00:00
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journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/j.envres.2003.12.001
更新日期:2004-11-01 00:00:00
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journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/j.envres.2011.01.001
更新日期:2011-02-01 00:00:00
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journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/j.envres.2012.08.007
更新日期:2013-01-01 00:00:00
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journal_title:Environmental research
pub_type: 杂志文章
doi:10.1006/enrs.1997.3804
更新日期:1998-05-01 00:00:00
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journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/j.envres.2020.109477
更新日期:2020-06-01 00:00:00
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journal_title:Environmental research
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更新日期:2015-11-01 00:00:00
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journal_title:Environmental research
pub_type: 杂志文章
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更新日期:2018-10-01 00:00:00
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journal_title:Environmental research
pub_type: 杂志文章
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更新日期:2020-09-01 00:00:00
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journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/j.envres.2019.108616
更新日期:2019-10-01 00:00:00
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journal_title:Environmental research
pub_type: 杂志文章
doi:10.1006/enrs.1997.3717
更新日期:1997-01-01 00:00:00
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journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/s0013-9351(05)80109-4
更新日期:1991-10-01 00:00:00
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journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/j.envres.2019.108786
更新日期:2019-12-01 00:00:00
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journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/s0013-9351(86)80169-4
更新日期:1986-10-01 00:00:00
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journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/j.envres.2017.11.028
更新日期:2018-02-01 00:00:00