Combined effects of perchlorate, thiocyanate, and iodine on thyroid function in the National Health and Nutrition Examination Survey 2007-08.


:Perchlorate, thiocyanate, and low iodine intake can all decrease iodide intake into the thyroid gland. This can reduce thyroid hormone production since iodide is a key component of thyroid hormone. Previous research has suggested that each of these factors alone may decrease thyroid hormone levels, but effect sizes are small. We hypothesized that people who have all three factors at the same time have substantially lower thyroid hormone levels than people who do not, and the effect of this combined exposure is substantially larger than the effects seen in analyses focused on only one factor at a time. Using data from the 2007-2008 National Health and Nutrition Examination Survey, subjects were categorized into exposure groups based on their urinary perchlorate, iodine, and thiocyanate concentrations, and mean serum thyroxine concentrations were compared between groups. Subjects with high perchlorate (n=1939) had thyroxine concentrations that were 5.0% lower (mean difference=0.40 μg/dl, 95% confidence interval=0.14-0.65) than subjects with low perchlorate (n=2084). The individual effects of iodine and thiocyanate were even smaller. Subjects with high perchlorate, high thiocyanate, and low iodine combined (n=62) had thyroxine concentrations 12.9% lower (mean difference=1.07 μg/dl, 95% confidence interval=0.55-1.59) than subjects with low perchlorate, low thiocyanate, and adequate iodine (n=376). Potential confounders had little impact on results. Overall, these results suggest that concomitant exposure to perchlorate, thiocyanate, and low iodine markedly reduces thyroxine production. This highlights the potential importance of examining the combined effects of multiple agents when evaluating the toxicity of thyroid-disrupting agents.


Environ Res


Environmental research


Steinmaus C,Miller MD,Cushing L,Blount BC,Smith AH




Has Abstract


2013-05-01 00:00:00












  • Cadmium and mercury exposure over time in Swedish children.

    abstract:PURPOSE:Knowledge about changes in exposure to toxic metals over time remains very sparse, in particular for children, the most vulnerable group. Here, we assessed whether a reduction in environmental pollution with cadmium (Cd) and mercury (Hg) caused a change in exposure over time. In total, 1257 children (age 4-9) i...

    journal_title:Environmental research

    pub_type: 杂志文章


    authors: Lundh T,Axmon A,Skerfving S,Broberg K

    更新日期:2016-10-01 00:00:00

  • Effects of Asian dust storm events on daily mortality in Taipei, Taiwan.

    abstract::In spring, windblown dust storms originating in the deserts of Mongolia and China make their way to Taipei City. These occurrences are known as Asian dust storm events. The objective of this study was to assess the possible effects of Asian dust storms on the mortality of residents in Taipei, Taiwan, during the period...

    journal_title:Environmental research

    pub_type: 杂志文章


    authors: Chen YS,Sheen PC,Chen ER,Liu YK,Wu TN,Yang CY

    更新日期:2004-06-01 00:00:00

  • Trace elements in Labrador Tea (Rhododendron groenlandicum): How predominant sources to the plants impact the chemical composition of hot water extracts.

    abstract::Labrador Tea (Rhododendron groenlandicum) has been an important food and medicinal plant to First Nations communities in North America for millenia, but little is known of its geochemical properties. Using plants from 10 sites in 4 provinces, including pristine and industrial regions, and employing the metal-free, ult...

    journal_title:Environmental research

    pub_type: 杂志文章


    authors: Shotyk W,Javed MB,Noernberg T

    更新日期:2020-04-01 00:00:00

  • Short-term physiological effects of a xenobiotic mixture on the freshwater mussel Elliptio complanata exposed to municipal effluents.

    abstract::The aim of this study was to investigate the short-term effects of tertiary-treated municipal effluents on the freshwater mussel Elliptio complanata. Caged mussels were immersed during 2 weeks in a river located North of Montreal Island, upstream/downstream the outfall and in one reference site located at the beginnin...

    journal_title:Environmental research

    pub_type: 杂志文章


    authors: Farcy E,Gagné F,Martel L,Fortier M,Trépanier S,Brousseau P,Fournier M

    更新日期:2011-11-01 00:00:00

  • Influence of bioaccessibility of total mercury, methyl-mercury and selenium on the risk/benefit associated to the consumption of raw and cooked blue shark (Prionace glauca).

    abstract::This study aimed to identify the benefit and risk associated with raw and cooked blue shark consumption taking into account the bioaccessibility of Se, Hg and MeHg, by using in vitro digestion method. Selenium, Hg and MeHg levels were higher in cooked samples, particularly in grilled blue shark. Whereas Se bioaccessib...

    journal_title:Environmental research

    pub_type: 杂志文章


    authors: Matos J,Lourenço HM,Brito P,Maulvault AL,Martins LL,Afonso C

    更新日期:2015-11-01 00:00:00

  • Indoor environmental quality in households of families with infant twins under 1 year of age living in Porto.

    abstract::Exposure to air pollution in early years can exacerbate the risk of noncommunicable diseases throughout childhood and the entire life course. This study aimed to assess temperature, relative humidity (RH), carbon dioxide (CO2) and monoxide (CO), particulate matter (PM2.5, PM10), ultrafine particles, nitrogen dioxide (...

    journal_title:Environmental research

    pub_type: 杂志文章


    authors: Gabriel MF,Felgueiras F,Batista R,Ribeiro C,Ramos E,Mourão Z,de Oliveira Fernandes E

    更新日期:2020-11-14 00:00:00

  • Effect of low-level NO2 chronic exposure on elastase-induced emphysema.

    abstract::The effect of chronic exposure to 2 ppm nitrogen dioxide (NO2) for 8 hr a day, 5 days a week, for 8 weeks was assessed in normal and emphysematous hamsters by measuring (1) lung morphometry (mean linear intercept [Lm] and internal surface area [ISA]), (2) lung mechanics (lung volume, compliance and coefficient of stat...

    journal_title:Environmental research

    pub_type: 杂志文章


    authors: Lafuma C,Harf A,Lange F,Bozzi L,Poncy JL,Bignon J

    更新日期:1987-06-01 00:00:00

  • Ice- and MOF-templated porous carbonaceous monoliths for adsorptive removal of dyes in water with easy recycling.

    abstract::Various nanoporous particles, nanofibers have been employed for adsorptive removal of dyes from wastewater. However, these nanomaterials are difficult in separation from solution, generally by centrifugation or filtration. These processes are tedious and will limit the upscale applications. Herein, a hierarchically po...

    journal_title:Environmental research

    pub_type: 杂志文章


    authors: Fu Q,Zhang L,Zhang H,Chen X,Li M,Gong M

    更新日期:2020-07-01 00:00:00

  • Explore the relationship between fish community and environmental factors by machine learning techniques.

    abstract::In the face of multiple habitat alterations originating from both natural and anthropogenic factors, the fast-changing environments pose significant challenges for maintaining ecosystem integrity. Machine learning is a powerful tool for modeling complex non-linear systems through exploratory data analysis. This study ...

    journal_title:Environmental research

    pub_type: 杂志文章


    authors: Hu JH,Tsai WP,Cheng ST,Chang FJ

    更新日期:2020-05-01 00:00:00

  • Lead exposure among small-scale battery recyclers, automobile radiator mechanics, and their children in Manila, the Philippines.

    abstract::Blood lead (PbB) and hemoglobin levels (Hb) were determined in 40 battery repair/recycling shop workers, 16 radiator repair shop workers, and 20 children living in the immediate vicinity of these shops. Unexposed residents with similar socioeconomic status were also investigated. Mean PbB level was significantly highe...

    journal_title:Environmental research

    pub_type: 杂志文章


    authors: Suplido ML,Ong CN

    更新日期:2000-03-01 00:00:00

  • The impact of heat waves on mortality in Northwest India.

    abstract::Heat waves are anticipated to worsen with climate change. India, an understudied area with >15% of the world's population, commonly experiences temperature extremes and already resembles potential future climates of more temperate regions. Registry data from local municipal corporations and government offices were col...

    journal_title:Environmental research

    pub_type: 杂志文章


    authors: Nori-Sarma A,Anderson GB,Rajiva A,ShahAzhar G,Gupta P,Pednekar MS,Son JY,Peng RD,Bell ML

    更新日期:2019-09-01 00:00:00

  • Air pollution, weather, and respiratory emergency room visits in two northern New England cities: an ecological time-series study.

    abstract::Daily emergency room (ER) visits for all respiratory (ICD-9 460-519) and asthma (ICD-9 493) were compared with daily sulfur dioxide (SO2), ozone (O3), and weather variables over the period 1998-2000 in Portland, Maine (population 248,000), and 1996-2000 in Manchester, New Hampshire (population 176,000). Seasonal varia...

    journal_title:Environmental research

    pub_type: 杂志文章


    authors: Wilson AM,Wake CP,Kelly T,Salloway JC

    更新日期:2005-03-01 00:00:00

  • A spatial analysis of climate gentrification in Orleans Parish, Louisiana post-Hurricane Katrina.

    abstract:BACKGROUND:Hurricane Katrina made landfall in New Orleans, Louisiana as a Category 3 storm in August 2005. Storm surges, levee failures, and the low-lying nature of New Orleans led to widespread flooding, damage to over 70% of occupied housing, and evacuation of 80-90% of city residents. Only 57% of the city's black po...

    journal_title:Environmental research

    pub_type: 杂志文章


    authors: Aune KT,Gesch D,Smith GS

    更新日期:2020-06-01 00:00:00

  • Neurocognitive and physical functioning in the Seveso Women's Health Study.

    abstract::2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is neurotoxic in animals but few studies have investigated its effects on the human brain. Related dioxin-like compounds have been linked to poorer cognitive and motor function in older adults, with effects more pronounced in women, perhaps due to the loss of neuro-protective...

    journal_title:Environmental research

    pub_type: 杂志文章


    authors: Ames J,Warner M,Brambilla P,Mocarelli P,Satariano WA,Eskenazi B

    更新日期:2018-04-01 00:00:00

  • Maternal blood and hair manganese concentrations, fetal growth, and length of gestation in the ISA cohort in Costa Rica.

    abstract:BACKGROUND:Animal studies have shown that both deficiency and excess manganese (Mn) may result in decreased fetal size and weight, but human studies have reported inconsistent results. METHODS:We examined the association of blood and hair Mn concentrations measured at different times during pregnancy with fetal growth...

    journal_title:Environmental research

    pub_type: 杂志文章


    authors: Mora AM,van Wendel de Joode B,Mergler D,Córdoba L,Cano C,Quesada R,Smith DR,Menezes-Filho JA,Eskenazi B

    更新日期:2015-01-01 00:00:00

  • Risk effects of high and low relative humidity on allergic rhinitis: Time series study.

    abstract:BACKGROUND:The relationship between environmental factors and allergic rhinitis (AR) has become a focal point recently. However, few studies have investigated the adverse effects of both high relative humidity (RH) and low relative humidity. Moreover, the laged effect and disease burden of RH on AR were also neglected....

    journal_title:Environmental research

    pub_type: 杂志文章


    authors: Duan J,Wang X,Zhao D,Wang S,Bai L,Cheng Q,Gao J,Xu Z,Zhang Y,Zhang H,Su H

    更新日期:2019-06-01 00:00:00

  • Fine particulate matter and cardiovascular disease: Comparison of assessment methods for long-term exposure.

    abstract:BACKGROUND:Adverse cardiovascular events have been linked with PM2.5 exposure obtained primarily from air quality monitors, which rarely co-locate with participant residences. Modeled PM2.5 predictions at finer resolution may more accurately predict residential exposure; however few studies have compared results across...

    journal_title:Environmental research

    pub_type: 杂志文章


    authors: McGuinn LA,Ward-Caviness C,Neas LM,Schneider A,Di Q,Chudnovsky A,Schwartz J,Koutrakis P,Russell AG,Garcia V,Kraus WE,Hauser ER,Cascio W,Diaz-Sanchez D,Devlin RB

    更新日期:2017-11-01 00:00:00

  • Adulthood dietary exposure to a common pesticide leads to an obese-like phenotype and a diabetic profile in apoE3 mice.

    abstract::Increasing evidence links the widespread exposure to organophosphate (OP) pesticides to the global epidemics of type 2 diabetes and obesity. Our recent data highlighted gene×environment interactions: mice expressing the human apolipoprotein E3 (apoE3) isoform were more prone to develop obesity than those expressing ap...

    journal_title:Environmental research

    pub_type: 杂志文章


    authors: Peris-Sampedro F,Cabré M,Basaure P,Reverte I,Domingo JL,Teresa Colomina M

    更新日期:2015-10-01 00:00:00

  • Decarbromodiphenyl ether (BDE-209) promotes monocyte-endothelial adhesion in cultured human aortic endothelial cells through upregulating intercellular adhesion molecule-1.

    abstract::There is growing evidence that exposure to persistent organic pollutants (POPs) is statistically associated with incidence of cardiovascular disease (CVD) or its risk factors. Decarbromodiphenyl ether (BDE-209) is a new POP which exists extensively in human tissues, but its potential effects on CVD have so far receive...

    journal_title:Environmental research

    pub_type: 杂志文章


    authors: Zhi H,Wu JP,Lu LM,Zhang XM,Chen XY,Wu SK,Tao J,Mai BX

    更新日期:2019-02-01 00:00:00

  • Impacts of high temperature on adverse birth outcomes in Seoul, Korea: Disparities by individual- and community-level characteristics.

    abstract:BACKGROUND:Few studies have examined temperature's effect on adverse birth outcomes and relevant effect modifiers. OBJECTIVES:We investigated associations between heat and adverse birth outcomes and how individual and community characteristics affect these associations for Seoul, Korea, 2004-2012. METHODS:We applied ...

    journal_title:Environmental research

    pub_type: 杂志文章


    authors: Son JY,Lee JT,Lane KJ,Bell ML

    更新日期:2019-01-01 00:00:00

  • Mercury exposures and symptoms in smelting workers of artisanal mercury mines in Wuchuan, Guizhou, China.

    abstract::Mercury exposures to smelting workers of artisanal mercury mines in Wuchuan, Guizhou, China were evaluated by urine and hair mercury survey. The mean urinary mercury (U-Hg), hair total mercury (T-Hg), and hair methyl mercury (Me-Hg) for smelting workers was 1060 microg/g creatinine (microg/g Cr), 69.3 and 2.32 microg/...

    journal_title:Environmental research

    pub_type: 杂志文章


    authors: Li P,Feng X,Qiu G,Li Z,Fu X,Sakamoto M,Liu X,Wang D

    更新日期:2008-05-01 00:00:00

  • Experimental lead toxicity in the ring-necked duck.

    abstract::Ring-necked ducks (Aythya collaris) were administered a single lead shot by gastric intubation. At weekly intervals over a 7-week period, the birds were weighed and blood samples obtained for measurement of hematocrit, free erythrocyte protoporphyrin (FEP), blood lead and delta-aminolevulinic acid dehydratase (delta-A...

    journal_title:Environmental research

    pub_type: 杂志文章


    authors: Mautino M,Bell JU

    更新日期:1986-12-01 00:00:00

  • A comparison of costs of universal versus targeted lead screening for young children.

    abstract::The purposes of this study were to compare universal blood lead screening for young children versus targeting by a risk assessment questionnaire and to examine the cost implications of each approach. Costs reflect the total number of blood tests required and cost of specimen collection, handling, and testing per eleva...

    journal_title:Environmental research

    pub_type: 杂志文章,多中心研究


    authors: Rolnick SJ,Nordin J,Cherney LM

    更新日期:1999-01-01 00:00:00

  • Solubilization of lead from crystal dust in protein solution (pseudointerstitial fluid) and gastric juice.

    abstract::Since several workers engaged in polishing and engraving crystal articles were found to have higher than average blood levels of lead (560 micrograms/liter, range 80-560 micrograms/liter), we investigated the hypothesis that crystal dust releases lead in the human body. To test the hypothesis, two types of crystal pol...

    journal_title:Environmental research

    pub_type: 杂志文章


    authors: Sciarra G,Sartorelli P,Aprea C,Scancarello G,Strambi F,Palmi S,Scarselli R

    更新日期:1997-01-01 00:00:00

  • Dietary intakes of selected elements from longitudinal 6-day duplicate diets for pregnant and nonpregnant subjects and elemental concentrations of breast milk and infant formula.

    abstract::As part of a longitudinal investigation into mobilization of lead from the maternal skeleton during pregnancy and lactation, we have determined the daily intake of selected elements (hereafter called micronutrients) for various subjects and compared these intakes with recommended and/or published intakes, especially t...

    journal_title:Environmental research

    pub_type: 杂志文章


    authors: Gulson BL,Mizon KJ,Korsch MJ,Mahaffey KR,Taylor AJ

    更新日期:2001-12-01 00:00:00

  • Risk of hospitalization for fire-related burns during extreme cold weather.

    abstract:BACKGROUND:Environmental factors are important predictors of fires, but no study has examined the association between outdoor temperature and fire-related burn injuries. We sought to investigate the relationship between extremely cold outdoor temperatures and the risk of hospitalization for fire-related burns. MATERIA...

    journal_title:Environmental research

    pub_type: 杂志文章


    authors: Ayoub A,Kosatsky T,Smargiassi A,Bilodeau-Bertrand M,Auger N

    更新日期:2017-10-01 00:00:00

  • Circulating levels of perfluoroalkyl substances (PFASs) and carotid artery atherosclerosis.

    abstract:BACKGROUND AND OBJECTIVE:During recent years, some persistent organic pollutants (POPs) have been linked to atherosclerosis. One group of POPs, the poly- and perfluoroalkyl substances (PFASs) have not been investigated with regard to atherosclerotic plaques. METHODS:Carotid artery atherosclerosis was assessed by ultra...

    journal_title:Environmental research

    pub_type: 杂志文章


    authors: Lind PM,Salihovic S,van Bavel B,Lind L

    更新日期:2017-01-01 00:00:00

  • Penile density and globally used chemicals in Canadian and Greenland polar bears.

    abstract::Industrially produced chemicals have been a major environmental concern across our entire Globe since the onset of rapid industrial development around the early 1900. Many of the substances being used are known to be endocrine disrupting chemicals (EDCs) and are also known to be long-range dispersed and to biomagnify ...

    journal_title:Environmental research

    pub_type: 杂志文章


    authors: Sonne C,Dyck M,Rigét FF,Beck Jensen JE,Hyldstrup L,Letcher RJ,Gustavson K,Gilbert MT,Dietz R

    更新日期:2015-02-01 00:00:00

  • Mercury exposure, risk factors, and perceptions among women of childbearing age in an artisanal gold mining region of the Peruvian Amazon.

    abstract::Recent studies from the Madre de Dios region of Peru report elevated mercury exposure among the general population. Our objective was to assess mercury exposure, risk factors, risk perceptions, and knowledge among women of childbearing age, a population of concern due to risks to infant and fetal health. We collected ...

    journal_title:Environmental research

    pub_type: 杂志文章


    authors: Gonzalez DJX,Arain A,Fernandez LE

    更新日期:2019-12-01 00:00:00

  • Polychlorinated biphenyls and thyroid hormone serum concentrations among people living in a highly polluted area: a cross-sectional population-based study.

    abstract:BACKGROUND:Polychlorinated biphenyls (PCBs) may interact with several thyroid functions. Severe environmental pollution by PCBs has been observed in Brescia, Italy, due to the presence of a factory that produced these compounds until 1984. OBJECTIVES:We aimed to investigate the correlation between serum levels of tota...

    journal_title:Environmental research

    pub_type: 杂志文章


    authors: Donato F,Zani C,Magoni M,Gelatti U,Covolo L,Orizio G,Speziani F,Indelicato A,Scarcella C,Bergonzi R,Apostoli P

    更新日期:2008-11-01 00:00:00