Abstract：
BACKGROUND:Feminization of animals derived from areas polluted by endocrine disrupting chemicals (EDCs) has been observed in all classes of vertebrates. However, feminization of artificially reared offspring by feeding of specific living organisms has never been reported. METHODS:Different food (including Limnodilus spp collected from the wild) and time treatment were applied to southern catfish. In addition, EDCs in Limnodilus spp., an annelid worm collected from wild contaminated small streams, was detected by LC-MS (Liquid chromatography-mass spectrometry). Serum estradiol-17β and vitellogenin (VTG) levels and gonadal Sf1, Dmrt1, Foxl2, Cyp19a1a expression levels in the catfish were measured through Estradiol/VTG EIA Kit and real-time PCR. RESULTS:Here we report that feeding of Limnodilus spp. resulted in complete feminization of southern catfish, which has a 1:1 sex ratio in wild conditions. Furthermore, HPLC analysis showed that the extraction of Limnodilus spp. contained EDCs, including bisphenol A (BPA), diethylstilbestrol (DES), 4-tert-octylphenol (4-t-OP) and 4-nonylphenol (4-NP), which were further confirmed by LC-MS. Feeding southern catfish using commercial diets sprayed with EDCs cocktail also resulted in 100% female, whereas the control fish displayed approximate 1:1 sex ratio. Limnodilus spp. fed fish displayed similar serum estradiol-17β and VTG levels and gonadal Sf1, Dmrt1, Foxl2, Cyp19a1a expression levels to those of female control. CONCLUSION:These results demonstrated that EDCs in Limnodilus spp. cause southern catfish feminization by affecting aromatase expression and endogenous estrogen level. This is the first report showing that feeding of any living organism resulted in complete feminization of a vertebrate.
journal_name
Environ Resjournal_title
Environmental researchauthors
Dong RR,Yang SJ,Feng RJ,Fang LL,Sun YL,Zhang YG,Xie XJ,Wang DSdoi
10.1016/j.envres.2014.05.018subject
Has Abstractpub_date
2014-08-01 00:00:00pages
371-9eissn
0013-9351issn
1096-0953pii
S0013-9351(14)00172-8journal_volume
133pub_type
杂志文章abstract：:Combined treatment of rats with lead and disulfiram is known to cause increased levels of lead in brain and potentiation of the neurotoxicity of lead. Ten dithiocarbamate and thiuram compounds, including disulfiram, were compared for their efficacies in influencing tissue distribution of a trace dose of intravenously ...
journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/s0013-9351(87)80088-9
更新日期：1987-10-01 00:00:00
abstract：BACKGROUND:Pesticide exposure has been found to cause renal damage and dysfunction in experimental studies, but epidemiological research on the renal effects of chronic low-level pesticide exposure is limited. We investigated the relationships between end-stage renal disease (ESRD) among wives of licensed pesticide app...
journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/j.envres.2015.10.002
更新日期：2015-11-01 00:00:00
abstract：BACKGROUND:Legionellosis' treatment failures have been recently reported showing the possibility of resistance development to traditional therapy, especially in healthcare related disease cases. Environmental impact of antibiotic residues, especially in hospital waters, may act on the resistome of Legionella resulting ...
journal_title：Environmental research
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.envres.2018.02.030
更新日期：2018-07-01 00:00:00
abstract：:Extreme cold and heat waves, characterized by a number of cold or hot days in succession, place a strain on people's cardiovascular and respiratory systems. The increase in deaths due to these waves may be greater than that predicted by extreme temperatures alone. We examined cold and heat waves in 99 US cities for 14...
journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/j.envres.2011.12.010
更新日期：2012-01-01 00:00:00
abstract：INTRODUCTION:According to the World Health Organisation (WHO), global warming has the potential to dramatically disrupt some of life's essential requirements for health, water, air and food. Understanding how Australians perceive the risk of global warming is essential for climate change policy and planning. The aim of...
journal_title：Environmental research
pub_type： 杂志文章,评审
doi：10.1016/j.envres.2010.09.007
更新日期：2010-11-01 00:00:00
abstract：:The aim of this study was to examine the relationship between insulin sensitivity and polychlorinated biphenyls (PCBs) exposure in non-diabetic pregnant women. Forty gravidas, 21-39 years of age and residing within the study area, were recruited. Seventeen 2,3,7,8-substituted dichloro-p-dioxin, dibenzofurans and 12 PC...
journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/j.envres.2008.01.004
更新日期：2008-06-01 00:00:00
abstract：:Methylmercury (MeHg) is the most bioavailable and toxic form of the globally distributed pollutant Hg. Organisms of higher trophic levels living in aquatic ecosystems have potentially higher concentrations of MeHg. In this work, we analysed both MeHg and inorganic Mercury (Hg(II)) concentrations from dorsal feathers o...
journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/j.envres.2020.109526
更新日期：2020-07-01 00:00:00
abstract：:In spring, windblown dust storms originating in the deserts of Mongolia and China make their way to Taipei City. These occurrences are known as Asian dust storm events. The objective of this study was to assess the possible effects of Asian dust storms on the mortality of residents in Taipei, Taiwan, during the period...
journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/j.envres.2003.08.008
更新日期：2004-06-01 00:00:00
abstract：:Airborne particles, including both ultrafine and supermicrometric particles, contain various carcinogens. Exposure and risk-assessment studies regularly use particle mass concentration as dosimetry parameter, therefore neglecting the potential impact of ultrafine particles due to their negligible mass compared to supe...
journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/j.envres.2015.07.019
更新日期：2015-10-01 00:00:00
abstract：:Based on 1677 published studies, 1648 sites across China collected from 1985 to 2016 were used to research the concentrations of arsenic in agricultural soils. In order to understand the status of arsenic pollution in agricultural soils in China over the past three decades, and to learn about the arsenic stocks in agr...
journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/j.envres.2020.109525
更新日期：2020-07-01 00:00:00
abstract：:Within a cross-sectional study, the neurotoxic effects of occupational exposure to manganese were examined. From a group of 90 (58 male and 32 female) workers, 11 men with long-term and high exposure to manganese dioxide (MnO2) dust were defined as exposed workers. Eleven age-matched workers of similar socioeconomic s...
journal_title：Environmental research
pub_type： 杂志文章
doi：10.1006/enrs.2000.4068
更新日期：2001-01-01 00:00:00
abstract：:Fimbristylis dichotoma, Ammannia baccifera and their co-plantation consortium FA independently degraded Methyl Orange, simulated dye mixture and real textile effluent. Wild plants of F. dichotoma and A. baccifera with equal biomass showed 91% and 89% decolorization of Methyl Orange within 60h at a concentration of 50p...
journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/j.envres.2017.09.009
更新日期：2018-01-01 00:00:00
abstract：:Bisphenol A (BPA) has been widely used in the manufacture of polycarbonate plastic and epoxy resins. In recent years, producers have started replacing BPA by other chemical analogues, such as bisphenol -S (BPS) and -F (BPF), all of them under the label "BPA-free". However, despite bisphenol (BP) analogues have a very ...
journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/j.envres.2019.108576
更新日期：2019-09-01 00:00:00
abstract：OBJECTIVE:Phthalates are non-persistent pollutants related to impaired metabolism and high cardiovascular risk. Their toxic metabolites are eliminated through urine and feces. Prevention policies are considered by the governments, although no therapeutic strategy to facilitate their elimination from the human body has ...
journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/j.envres.2020.110316
更新日期：2021-01-01 00:00:00
abstract：:Trichloroethylene (TCE) is a frequently found organic contaminant in polluted-groundwater. In this microcosm study, effects of hydrogen-producing bacteria [Clostridium butyricum (Clostridium sp.)] and inhibitor of sulfate-reducing bacteria (SRB) addition on the enhancement of TCE dechlorination were evaluated. Results...
journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/j.envres.2020.109629
更新日期：2020-08-01 00:00:00
abstract：:At 56 days of age, male and female Long-Evans rats received 1 mumole of 203Hg-labeled methyl mercuric chloride per kilogram sc and total, organic, and inorganic mercury contents and concentrations in tissues were determined for up to 98 days postdosing. Whole body clearance of mercury was faster in females than in mal...
journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/s0013-9351(86)80184-0
更新日期：1986-10-01 00:00:00
abstract：BACKGROUND:Few studies have examined temperature's effect on adverse birth outcomes and relevant effect modifiers. OBJECTIVES:We investigated associations between heat and adverse birth outcomes and how individual and community characteristics affect these associations for Seoul, Korea, 2004-2012. METHODS:We applied ...
journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/j.envres.2018.10.032
更新日期：2019-01-01 00:00:00
abstract：:The cytotoxic activity of the DQ-12 standard dust on the external structure of peritoneal macrophages, after intraperitoneal introduction, was investigated, vs nontreated macrophages, and kept in in vitro cultures for 3, 6, and 24 hr. The alterations related to the external structure were investigated by scanning elec...
journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/0013-9351(83)90002-6
更新日期：1983-08-01 00:00:00
abstract：:Relatively little attention has been devoted to the risks from mercury in saltwater fish, that were caught by recreational fisherfolk. Although the US Food and Drug Administration has issued advisories based on mercury for four saltwater species or groups of fish, there are few data on how mercury levels vary by size,...
journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/j.envres.2009.07.005
更新日期：2009-10-01 00:00:00
abstract：:To determine whether a population living on or adjacent to four sites of chromate production waste was measurably exposed to environmental chromium, spot samples of urine were collected along with wipe samples of household dust and lifestyle/activity interview data. Findings were compared to those from a control popul...
journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/s0013-9351(05)80211-7
更新日期：1992-08-01 00:00:00
abstract：:During the last few years, there has been an alarming increase in the amount of nickel (Ni) being released into the environment, primarily due to its use in the production of stainless steel but also from other sources such as batteries manufacturing and consequent disposal. The established biotic ligand models provid...
journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/j.envres.2019.05.038
更新日期：2019-09-01 00:00:00
abstract：:Cadmium (Cd) was determined in kidney cortex and liver of 173 autopsied Japanese. Subjects consisted of 51 persons from Cd-polluted areas ages between 61-94 years and 122 controls ages between 3-90 years. The mean Cd concentrations for the Cd-polluted group were 35.2 micrograms/g wet wt for kidney cortex and 66.7 micr...
journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/s0013-9351(86)80101-3
更新日期：1986-08-01 00:00:00
abstract：:Air pollution caused by particulate matter (PM) has become a serious issue, and significant research has focused on managing large stationary emission sources, i.e., the primary sources of PM. Currently, the U.S. Environmental Protection Agency (EPA) Method 201A and ISO 23210 are predominantly employed to measure the ...
journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/j.envres.2020.110507
更新日期：2021-02-01 00:00:00
abstract：:The effect of chronic exposure to 2 ppm nitrogen dioxide (NO2) for 8 hr a day, 5 days a week, for 8 weeks was assessed in normal and emphysematous hamsters by measuring (1) lung morphometry (mean linear intercept [Lm] and internal surface area [ISA]), (2) lung mechanics (lung volume, compliance and coefficient of stat...
journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/s0013-9351(87)80059-2
更新日期：1987-06-01 00:00:00
abstract：:Approximately 10% of women report smoking during pregnancy. The number of breastfeeding women who relapse back to smoking is even greater. Smoking may cause adverse changes to the milk's composition by not only reducing its protective properties, but also by affecting the infant's health. The pathophysiological mechan...
journal_title：Environmental research
pub_type： 杂志文章,评审
doi：10.1016/j.envres.2016.08.002
更新日期：2016-11-01 00:00:00
abstract：:The spread of pharmaceutically active chemicals (PACs), such as antibiotics and estrogenic hormones from animal manures can pose threats to the ecologic environment. In this work, animal manure samples were collected from 71 concentrated animal feedlots in Northern China and investigated for 24 antibiotics and 4 estro...
journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/j.envres.2020.110463
更新日期：2020-11-13 00:00:00
abstract：:Continuous air quality monitoring in the Vojvodina district of Serbia and Montenegro has shown high levels of Cd, especially in the outskirts of large towns such as Kikinda. The construction and metal processing industries located in Kikinda have been emitting significant amounts of heavy metals into the environment. ...
journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/j.envres.2004.05.008
更新日期：2005-01-01 00:00:00
abstract：:The use of cellular phones is now ubiquitous through most of the adult global population and is increasingly common among even young children in many countries (e.g. Finland, where the market for smart phones is nearly saturated). The basic operation of cellular phone networks demands widespread human exposure to radi...
journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/j.envres.2019.108845
更新日期：2020-02-01 00:00:00
abstract：:Closing the gap between carbon emissions and economic development is one of the solutions for reaching the sustainable development goals (SDGs). The role of renewable energy in rebalancing environmental and economic conditions is becoming a significant subject of some debates in the current discussion circles. Hence, ...
journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/j.envres.2020.109567
更新日期：2020-07-01 00:00:00
abstract：BACKGROUND:Inorganic arsenic exposure is ubiquitous and both exposure and inter-individual differences in its metabolism have been associated with cardiometabolic risk. A more efficient arsenic metabolism profile (lower MMA%, higher DMA%) has been associated with reduced risk for arsenic-related health outcomes. This p...
journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/j.envres.2018.09.034
更新日期：2019-01-01 00:00:00
