Effects of exposure of blood hemoglobin to nitric oxide.

Abstract:

:The effect of oxygen exposure on nitrosylhemoglobin of whole human blood or its buffered solution has been determined. The amount of methemoglobin formed was determined by an anaerobic modification of the Evelyn-Malloy method; 59% of the total hemoglobin of whole blood was oxidized to methemoglobin in the first 15 min of the oxygen exposure and 78% of the total hemoglobin was oxidized after 120 min of oxygen exposure. Similar results were obtained when nitrosylhemoglobin buffered solutions were exposed to the oxygen of the air. A comparison of the present in vitro results with these obtained by injecting nitric oxide into the rat peritoneal cavity and its implications are discussed.

journal_name

Environ Res

journal_title

Environmental research

authors

Chiodi H,Mohler JG

doi

10.1016/0013-9351(85)90116-1

subject

Has Abstract

pub_date

1985-08-01 00:00:00

pages

355-63

issue

2

eissn

0013-9351

issn

1096-0953

pii

0013-9351(85)90116-1

journal_volume

37

pub_type

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