Abstract：
:There are very few metabolomics assessments based on field accumulated, uncontrolled contaminant exposures in wildlife, particularly in the Arctic. In the present study, targeted metabolomics and contaminant data were analyzed together to assess potential influences of contaminant exposure on the hepatic metabolome of male polar bears (n = 29) from the southern and western Hudson Bay (SHB and WHB respectively), Canada. The 29 metabolites identified as important in the differentiation of the two subpopulations after partial least squares discriminant analysis (PLS-DA) included phosphatidylcholines (PCs), acylcarnitines (ACs; involved in β-oxidation of fatty acids), and the fatty acid (FA) arachidonic acid (ARA). Perfluorinated alkyl substances, polybrominated diphenyl ethers, dichlorodiphenyldichloroethylene (p,p'-DDE) and some highly chlorinated ortho-polychlorinated biphenyl congeners were greater in the SHB bears and were consistently inversely correlated with discriminating ACs and PCs between the subpopulations. The concentrations of discriminatory, legacy organochlorine pesticides along with one tetrachlorobiphenyl were greater in the WHB and were directly correlated with the VIP-identified ACs and PCs. ARA, glycerophospholipid and several amino acid metabolic pathways were identified as different between subpopulations and/or were impacted. ARA is an important, conditionally essential, dietary n-6 FA and is also part of the inflammation response, and elevated concentrations in the SHB could be related to differences in chronic contaminant exposure and/or differences in diet and/or season, among a number of possible explanations. Dietary tracers (stable isotopes of carbon and nitrogen) were correlated with some discriminatory metabolites, supporting the hypothesis that dietary variation was also an important factor in the differentiation of the subpopulations. The results suggest linkages between contaminant exposure in Hudson Bay polar bears and elements of the hepatic metabolome, particularly those related to lipid metabolism.
journal_name
Environ Resjournal_title
Environmental researchauthors
Morris AD,Letcher RJ,Dyck M,Chandramouli B,Cosgrove Jdoi
10.1016/j.envres.2018.10.001subject
Has Abstractpub_date
2019-01-01 00:00:00pages
364-374eissn
0013-9351issn
1096-0953pii
S0013-9351(18)30541-3journal_volume
168pub_type
杂志文章abstract：:The adsorption dynamics of common solid sorbents against various pollutant species are yet poorly understood with respect to the retrograde phenomenon in which the relationship between breakthrough vs. pulled volume is characterized by an early unusual trend (initial increase followed by a decrease to a minimum) and b...
journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/j.envres.2019.108737
更新日期：2019-11-01 00:00:00
abstract：:Fimbristylis dichotoma, Ammannia baccifera and their co-plantation consortium FA independently degraded Methyl Orange, simulated dye mixture and real textile effluent. Wild plants of F. dichotoma and A. baccifera with equal biomass showed 91% and 89% decolorization of Methyl Orange within 60h at a concentration of 50p...
journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/j.envres.2017.09.009
更新日期：2018-01-01 00:00:00
abstract：:Exposure to hazardous Hg can adversely affect children's neurodevelopment. However, few data are available on either Hg levels in neonates and their mothers or the impact of prenatal exposure to Hg on neonates' neurobehavioral development in the Chinese population. Therefore, this study examined Hg levels in neonates ...
journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/j.envres.2007.05.015
更新日期：2007-11-01 00:00:00
abstract：:The study aims at investigating the characteristics (size distribution, active surface and metal content) of particles emitted by cars as a function of mileage using a novel methodology for characterizing particulate emissions captured by Exhaust Gas Suspension (EGS). EGS was obtained by passing the exhaust gases thro...
journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/j.envres.2015.07.018
更新日期：2015-10-01 00:00:00
abstract：:Patterns of mortality in 11 air-conditioned and 9 un-air-conditioned nursing homes in New York City have been investigated to determine the impacts of heat waves on nursing home occupants and the efficacy of air conditioning in reducing these impacts. During each of four heat waves in 1972 and 1973, the number of deat...
journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/0013-9351(78)90065-8
更新日期：1978-08-01 00:00:00
abstract：:We assessed the association between blood methylmercury (MeHg) and cognitive function in 240 adult residents living near a deserted chloralkali plant. Total mercury (T-Hg) in the blood, MeHg, and health and dietary related questionnaire were examined for all participants. The Cognitive Abilities Screening Instrument (...
journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/j.envres.2008.06.006
更新日期：2008-11-01 00:00:00
abstract：BACKGROUND:It is unknown if higher levels of ambient particulate matter (PM) exposure increase the risk for premature ventricular contractions (PVC) in a population-based study of men and women, and if this relationship varies by race or sex. METHODS:We examined the association of PM <2.5µm in diameter (PM2.5) concent...
journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/j.envres.2016.12.031
更新日期：2017-04-01 00:00:00
abstract：:Mercury (Hg) has been shown to have immunotoxic effects and to influence the severity of infection. However, the impact of infection on the normal Hg homeostasis in different target organs involved in the disease process has not been studied. In this study, Hg was measured through inductively coupled plasma-mass spect...
journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/j.envres.2007.08.002
更新日期：2008-02-01 00:00:00
abstract：BACKGROUND:Exposure to fine particles in the atmosphere can adversely affect health and even lead to premature death. Recently, South Korea has attracted attention because of its rapid increase in the concentration of Particulate Matter (PM). OBJECTIVES:We estimated the economic benefits of reducing PM10 in Seoul, Sou...
journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/j.envres.2019.03.042
更新日期：2019-06-01 00:00:00
abstract：:Research and development (R&D) activities are frequently undertaken as a powerful means to improve a country's environmental performance. However, previous studies examine R&D activities as a whole, and thus do not provide detailed information, such as the carbon intensity reduction of individual actors or stages. In ...
journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/j.envres.2020.109947
更新日期：2020-11-01 00:00:00
abstract：BACKGROUND:Several in vivo and in vitro studies have shown that metal-rich particles may enhance allergic responses to house dust mites and induce an increased release of allergy-related cytokines. OBJECTIVES:The main goal of this analysis is to define the possible association of intrauterine exposure to lead and merc...
journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/j.envres.2010.11.002
更新日期：2011-01-01 00:00:00
abstract：:Firefighter uniforms protect firefighters from exposure to potentially harmful chemicals including a range of semi-volatile organic compounds (SVOCs). Contaminated uniforms can become a secondary source of firefighters' exposure to these chemicals. There is inconsistency on the removal efficiency of SVOCs during the c...
journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/j.envres.2020.110616
更新日期：2020-12-13 00:00:00
abstract：:Powerful scientific techniques have caused dramatic expansion of genetically modified crops leading to altered agricultural practices posing direct and indirect environmental implications. Despite the enhanced yield potential, risks and biosafety concerns associated with such GM crops are the fundamental issues to be ...
journal_title：Environmental research
pub_type： 杂志文章,评审
doi：10.1016/j.envres.2017.03.011
更新日期：2017-07-01 00:00:00
abstract：BACKGROUND:Feminization of animals derived from areas polluted by endocrine disrupting chemicals (EDCs) has been observed in all classes of vertebrates. However, feminization of artificially reared offspring by feeding of specific living organisms has never been reported. METHODS:Different food (including Limnodilus s...
journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/j.envres.2014.05.018
更新日期：2014-08-01 00:00:00
abstract：:Although there is indirect evidence to suggest that persistent organochlorines might increase risk of hypertensive disorders of pregnancy, there are no epidemiologic studies directly addressing this question. In this cohort study, sampled from the Collaborative Perinatal Project, 1933 women had complete data on organo...
journal_title：Environmental research
pub_type： 杂志文章,多中心研究
doi：10.1016/j.envres.2014.03.020
更新日期：2014-07-01 00:00:00
abstract：:Polycyclic aromatic hydrocarbons (PAH) are widespread contaminants in the San Francisco Bay. Several exceedances of water quality criteria raise the possibility that PAH may be impacting aquatic biota. The Regional Monitoring Program for Water Quality in the San Francisco Estuary (RMP) has collected annual monitoring ...
journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/j.envres.2006.10.007
更新日期：2007-09-01 00:00:00
abstract：:Epidemiologic studies have suggested that exposure to solvent-based materials in the painting trades is associated with an increased cancer risk. In order to determine if the solvent exposures of current union members of the International Brotherhood of Painters and Allied Tradesman (IBPAT) are associated with a genot...
journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/s0013-9351(89)80005-2
更新日期：1989-12-01 00:00:00
abstract：:In Germany the impact of socioeconomic factors on environmental exposures and adverse housing conditions has been rarely studied up to now. The aim of our study was to assess whether and, if yes, how perceived exposure to noise and air pollution is influenced by socioeconomic status in Germany. We used data from a lar...
journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/j.envres.2005.09.008
更新日期：2006-06-01 00:00:00
abstract：:Alien species contribute to global change in all marine ecosystems. Environmental variability can affect species distribution and population sizes, and is therefore expected to influence alien species. In this study, we have investigated temporal variability of 11 alien species representing different trophic levels an...
journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/j.envres.2011.03.002
更新日期：2011-10-01 00:00:00
abstract：:Residents in close proximity to agricultural land are at risk of higher pesticide exposures. The purpose of this study was to generate national population-level exposure estimates for Canada for three commonly applied pesticides that are suspected carcinogens (2,4-dichlorophenoxyacetic acid (2,4-D), glyphosate and chl...
journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/j.envres.2020.110100
更新日期：2020-12-01 00:00:00
abstract：:Bisphenol A (BPA) and its main substitute, bisphenol S (BPS), are synthetic organic compounds found in various consumer products, in particular food and beverage containers. Numerous reports have shown a link between bisphenol exposure, human contamination and increased health problems. BPA, BPS and their metabolites ...
journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/j.envres.2020.110336
更新日期：2020-10-20 00:00:00
abstract：:This study uses soil lead as a means of describing the urban lead levels in the metropolitan area of the Twin Cities, and assesses the soil lead levels next to homes of neighborhoods of the metropolitan area. Lead levels of rural soils are around 5 micrograms/g. Near the city limits they increase to 25-50 micrograms/g...
journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/0013-9351(84)90076-8
更新日期：1984-06-01 00:00:00
abstract：BACKGROUND:Extracellular vesicles (EVs) represent a plausible molecular mechanism linking particulate matter (PM) inhalation to its systemic effects. Microvesicles (MVs) are released from many cell types in response to various stimuli. Increased body mass index (BMI) could modify the response to PM exposure due to enha...
journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/j.envres.2017.02.014
更新日期：2017-05-01 00:00:00
abstract：:One year-long criteria air pollutants data collected in Beijing were analyzed in this paper, which can support the research on formation, transport and human health effects of air pollutants. This is the first time to study the spatial and temporal variations of criteria pollutants in Beijing using hourly observationa...
journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/j.envres.2017.01.029
更新日期：2017-04-01 00:00:00
abstract：BACKGROUND:Multiple sclerosis (MS) is a chronic, inflammatory, demyelinating disease of the central nervous system, characterized by recurrent relapses of inflammation that cause mild to severe disability. Exposure to airborne particulate matter (PM) has been associated with acute increases in systemic inflammatory res...
journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/j.envres.2015.11.017
更新日期：2016-02-01 00:00:00
abstract：:It has been established as a common knowledge that ambient air pollution (AAP) has an adverse effect on human health. The pathophysiological mechanism of this impact is likely to be related to the oxidative stress. In the current study we estimate the association between AAP and cell proliferation (CP) of umbilical co...
journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/j.envres.2016.09.009
更新日期：2016-11-01 00:00:00
abstract：:We describe differences by sex in genotoxic damage found in a population of medical students exposed to a highly oxidative atmosphere, compared with a control group, measured by the single-cell gel electrophoresis assay and histological changes in nasal epithelium smears. Cells were obtained from the nasal epithelium ...
journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/S0013-9351(03)00093-8
更新日期：2004-03-01 00:00:00
abstract：:The human biomonitoring (HBM) of metals is a part of the ongoing project SPoTT for the longitudinal health surveillance of the population living near a waste-to-energy (WTE) incinerator (Turin, Italy). The HBM of metals in the SPoTT population aimed to evaluate: i) reference values (RVs) before the WTE incinerator sta...
journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/j.envres.2016.04.013
更新日期：2016-07-01 00:00:00
abstract：:The reuse of treated wastewater (TWW) for irrigation and the use of biosolids and manures as soil amendment constitute significant pathways for the introduction of the contaminants of emerging concern (CECs) to the agricultural environment. Consequently, CECs are routinely detected in TWW-irrigated agricultural soils ...
journal_title：Environmental research
pub_type： 杂志文章,评审
doi：10.1016/j.envres.2018.12.048
更新日期：2019-03-01 00:00:00
abstract：:Phthalates are potentially involved in the development of type 2 diabetes mellitus. In a cohort of 123 obese subjects, 10 phthalate metabolites were analyzed. An oral glucose tolerance test was performed and various estimates of insulin resistance and beta-cell function were calculated. After adjustment for age, physi...
journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/j.envres.2015.01.010
更新日期：2015-02-01 00:00:00
