Abstract：
:Several epidemiological studies have shown that the farm environment impacts allergy protection mechanisms in children. These associations are not well understood, but it is thought that contact to microorganisms may mediate this effect. For example, heat-inactivated Listeria (L.) monocytogenes have been successfully used as an adjuvant in mouse immunotherapy to modulate airway hyperreactivity and inflammation. In investigating the link between farming lifestyle and prevention of childhood allergy, we examined the prevalence of Listeria spp. in dust specimens from the environment of rural children. A total of 26 farms located in Bavaria (South Germany) were examined. Dust samples taken from mattresses (n=63), cow-sheds (n=30) and swine-sheds (n=10) were qualitatively screened for the presence of viable Listeria spp. according to the ISO 11290-1 method and additionally by L. monocytogenes specific iap-based real-time PCR. Isolates were further characterized by biochemical techniques, serology and multiplex PCR. Nineteen of 26 farms tested positive for Listeria spp. and seven were tested negative. The dominant species found by culturing methods were L. innocua (n=12) and L. monocytogenes (n=8). Viable Listeria spp. were detected in 8% of the mattress dust samples, whereas real-time PCR revealed 60% L. monocytogenes positive specimens. Regarding animal sheds, 28% of dust samples showed viable Listeria spp., while using real-time PCR found that 28% of specimens were L. monocytogenes positive. All strains of L. monocytogenes except one (4ab) belonged to the serotype 1/2a. Our data demonstrate that a substantial number of farm children's beds contain L. monocytogenes. The importance of this result regarding the health of children must be evaluated by epidemiological investigations on both the risk of listeriosis and the effects on protection against allergies.
journal_name
Environ Resjournal_title
Environmental researchauthors
Korthals M,Ege M,Lick S,von Mutius E,Bauer Jdoi
10.1016/j.envres.2008.02.007subject
Has Abstractpub_date
2008-07-01 00:00:00pages
299-304issue
3eissn
0013-9351issn
1096-0953pii
S0013-9351(08)00064-9journal_volume
107pub_type
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journal_title：Environmental research
pub_type： 杂志文章,评审
doi：10.1016/j.envres.2020.110660
更新日期：2020-12-31 00:00:00
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更新日期：2017-10-01 00:00:00
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journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/j.envres.2007.10.008
更新日期：2008-02-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/0013-9351(84)90096-3
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更新日期：1990-04-01 00:00:00
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pub_type： 杂志文章
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更新日期：2021-01-21 00:00:00
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pub_type： 杂志文章,评审
doi：10.1006/enrs.2000.4110
更新日期：2001-02-01 00:00:00
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pub_type： 杂志文章
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更新日期：2019-07-01 00:00:00
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pub_type： 杂志文章
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更新日期：2021-01-08 00:00:00
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pub_type： 杂志文章
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更新日期：2015-10-01 00:00:00
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journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/j.envres.2016.03.025
更新日期：2016-07-01 00:00:00
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pub_type： 杂志文章
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更新日期：2011-11-01 00:00:00
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journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/j.envres.2020.110171
更新日期：2020-12-01 00:00:00
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journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/j.envres.2019.108621
更新日期：2019-10-01 00:00:00
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journal_title：Environmental research
pub_type： 杂志文章,meta分析,评审
doi：10.1016/j.envres.2017.08.002
更新日期：2017-11-01 00:00:00
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journal_title：Environmental research
pub_type： 杂志文章,评审
doi：10.1016/j.envres.2016.02.038
更新日期：2016-05-01 00:00:00
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journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/s0013-9351(05)80109-4
更新日期：1991-10-01 00:00:00
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journal_title：Environmental research
pub_type： 杂志文章
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更新日期：2003-03-01 00:00:00
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journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/j.envres.2007.08.003
更新日期：2008-05-01 00:00:00
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pub_type： 杂志文章,随机对照试验
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更新日期：2018-07-01 00:00:00
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journal_title：Environmental research
pub_type： 杂志文章
doi：10.1006/enrs.1999.4009
更新日期：2000-02-01 00:00:00
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journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/j.envres.2003.08.005
更新日期：2004-05-01 00:00:00
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journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/0013-9351(83)90002-6
更新日期：1983-08-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/j.envres.2019.03.015
更新日期：2019-09-01 00:00:00
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journal_title：Environmental research
pub_type： 杂志文章
doi：10.1006/enrs.2001.4317
更新日期：2002-01-01 00:00:00
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journal_title：Environmental research
pub_type： 杂志文章
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更新日期：2018-02-01 00:00:00
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journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/j.envres.2016.08.013
更新日期：2016-11-01 00:00:00
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journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/0013-9351(83)90076-2
更新日期：1983-06-01 00:00:00
