当前位置： SCI文献检索 > Journal of Proteomics期刊下所有文献 > Effect of diethylcarbamazine, butylated hydroxy anisole and methyl substituted chalcone on filarial parasite Setaria cervi: proteomic and biochemical approaches.

Effect of diethylcarbamazine, butylated hydroxy anisole and methyl substituted chalcone on filarial parasite Setaria cervi: proteomic and biochemical approaches.

Abstract：

:For survival, parasite exerts several lines of defense of which drug neutralization is one of the major phenomena. Lack of phase I cytochrome P450 in some of the nematode render them depend on the phase II detoxification system involving GST as a major detoxifying enzymes. In present study, the antifilarial DEC, phenolic compound BHA and methyl chalcone have been evaluated for proteomic and biochemical studies in Setaria cervi. BHA and methyl chalcone showed cytotoxic effect leading to irreversible inhibition in motility and viability of parasites. These drugs showed marked alteration in proteomic profile of S. cervi at 100 μM concentration with 10.82, 8.52 and 6.75% downregulated (<0.5) and 7.64, 31.78 and 24.32% upregulated (>1.5) in DEC, BHA and methyl chalcone treatment respectively. Significant depletion in GSH level with increase in NO production was observed. Amongst these compounds, methyl chalcone demonstrated significant inhibitory effect (p<0.05) on GST, PGHS and PTP activity leading to loss of metabolic homeostasis and parasite death. The cytotoxic response and altered expression profile of major enzymes under drug exposure suggested the oxidative stress induced apoptosis as a major cause of parasite killing which was further supported by DNA fragmentation in BHA and methyl chalcone.

journal_name

J Proteomics

journal_title

Journal of proteomics

authors

Rathaur S,Yadav M,Singh N,Singh A

doi

10.1016/j.jprot.2011.04.020

subject

Has Abstract

pub_date

2011-08-24 00:00:00

pages

1595-606

issue

9

eissn

1874-3919

issn

1876-7737

pii

S1874-3919(11)00179-5

journal_volume

74

pub_type

杂志文章

相关文献

Journal of Proteomics文献大全
  • Intrinsic disorder and multiple phosphorylations constrain the evolution of the flightin N-terminal region.

    abstract：:Flightin is a myosin binding phosphoprotein that originated in the ancestor to Pancrustacea ~500 MYA. In Drosophila melanogaster, flightin is essential for length determination and flexural rigidity of thick filaments. Here, we show that among 12 Drosophila species, the N-terminal region is characterized by low sequen...

    journal_title：Journal of proteomics

    pub_type： 杂志文章

    doi：10.1016/j.jprot.2015.12.006

    authors： Lemas D,Lekkas P,Ballif BA,Vigoreaux JO

    更新日期：2016-03-01 00:00:00

  • Technical report: Targeted proteomic analysis reveals enrichment of atypical ubiquitin chains in contractile murine tissues.

    abstract：:Ubiquitylation is an elaborate post-translational modification involved in all biological processes. Its pleotropic effect is driven by the ability to form complex polyubiquitin chain architectures that can influence biological functions. In this study, we optimised sample preparation and chromatographic separation of...

    journal_title：Journal of proteomics

    pub_type： 杂志文章

    doi：10.1016/j.jprot.2020.103963

    authors： Heunis T,Lamoliatte F,Marín-Rubio JL,Dannoura A,Trost M

    更新日期：2020-10-30 00:00:00

  • Assessment of the humoral immune response to cancer.

    abstract：:One of the deadly hallmarks of cancer is its ability to prosper within the constraints of the host immune system. Recent advances in immunoproteomics and high-throughput technologies have lead to profiling of the antibody repertoire in cancer patients. This in turn has lead to the identification of tumour associated a...

    journal_title：Journal of proteomics

    pub_type： 杂志文章,评审

    doi：10.1016/j.jprot.2012.01.021

    authors： Murphy MA,O'Leary JJ,Cahill DJ

    更新日期：2012-08-03 00:00:00

  • Secretome proteomics for discovery of cancer biomarkers.

    abstract：:"Secretome" is referred to as the rich, complex set of molecules secreted from living cells. In a less strict definition frequently followed in "secretome" studies, the term also includes molecules shed from the surface of living cells. Proteins of secretome (will be referred to as secreted) play a key role in cell si...

    journal_title：Journal of proteomics

    pub_type： 杂志文章,评审

    doi：10.1016/j.jprot.2010.07.001

    authors： Makridakis M,Vlahou A

    更新日期：2010-11-10 00:00:00

  • Proteomic expression profiles of virulent and avirulent strains of Listeria monocytogenes isolated from macrophages.

    abstract：:Listeria monocytogenes is able to survive and proliferate within macrophages. In the current study, the ability of three L. monocytogenes strains (serovar 1/2a strain EGDe, serovar 4b strain F2365, and serovar 4a strain HCC23) to proliferate in the murine macrophage cell line J774.1 was analyzed. We found that the avi...

    journal_title：Journal of proteomics

    pub_type： 杂志文章

    doi：10.1016/j.jprot.2011.05.008

    authors： Donaldson JR,Nanduri B,Pittman JR,Givaruangsawat S,Burgess SC,Lawrence ML

    更新日期：2011-09-06 00:00:00

  • Proteomic analysis and protein carbonylation profile in trained and untrained rat muscles.

    abstract：:Understanding the relationship between physical exercise, reactive oxygen species and skeletal muscle modification is important in order to better identify the benefits or the damages that appropriate or inappropriate exercise can induce. Unbalanced ROS levels can lead to oxidation of cellular macromolecules and a maj...

    journal_title：Journal of proteomics

    pub_type： 杂志文章

    doi：10.1016/j.jprot.2011.10.017

    authors： Magherini F,Abruzzo PM,Puglia M,Bini L,Gamberi T,Esposito F,Veicsteinas A,Marini M,Fiorillo C,Gulisano M,Modesti A

    更新日期：2012-01-04 00:00:00

  • Applicability of 2-DE to assess differences in the protein profile between cold storage and not cold storage in nectarine fruits.

    abstract：:Cold storage is being used to increase nectarine fruits' postharvest life. However, low temperatures lead to chilling injury and limit their commercial quality and value. In this study a proteomic approach was used to compare the protein profile between control and cold storage nectarine fruits. Protein extracted from...

    journal_title：Journal of proteomics

    pub_type： 杂志文章

    doi：10.1016/j.jprot.2012.08.005

    authors： Giraldo E,Díaz A,Corral JM,García A

    更新日期：2012-10-22 00:00:00

  • Glycoproteome in silkworm Bombyx mori and alteration by BmCPV infection.

    abstract：:The biological functions of protein glycosylation have been increasingly recognized but not yet been very well understood, especially in lower organisms. Silkworm as a model lepidopteran insect and important economic insect, has been widely studied in life science, however, the current knowledge on the glycosylation s...

    journal_title：Journal of proteomics

    pub_type： 杂志文章

    doi：10.1016/j.jprot.2020.103802

    authors： Zhu F,Li D,Song D,Huo S,Ma S,Lü P,Liu X,Yao Q,Chen K

    更新日期：2020-06-30 00:00:00

  • The use of omics profiling to improve outcomes of bone regeneration and osseointegration. How far are we from personalized medicine in dentistry?

    abstract：:Increased life expectancy and broader restorative dental treatment alternatives for missing teeth have resulted in an increasing request of bone regeneration/augmentation procedures not only in healthy patients, but also in elderly and medically compromised ones. This is also combined with a growing demand for short i...

    journal_title：Journal of proteomics

    pub_type： 杂志文章,评审

    doi：10.1016/j.jprot.2018.01.017

    authors： Calciolari E,Donos N

    更新日期：2018-09-30 00:00:00

  • Comparative leaf proteomics of drought-tolerant and -susceptible peanut in response to water stress.

    abstract：UNLABELLED:Water stress (WS) predisposes peanut plants to fungal infection resulting in pre-harvest aflatoxin contamination. Major changes during water stress including oxidative stress, lead to destruction of photosynthetic apparatus and other macromolecules within cells. Two peanut cultivars with diverse drought tole...

    journal_title：Journal of proteomics

    pub_type： 杂志文章

    doi：10.1016/j.jprot.2016.05.031

    authors： Katam R,Sakata K,Suravajhala P,Pechan T,Kambiranda DM,Naik KS,Guo B,Basha SM

    更新日期：2016-06-30 00:00:00

  • Venomics of the Duvernoy's gland secretion of the false coral snake Rhinobothryum bovallii (Andersson, 1916) and assessment of venom lethality towards synapsid and diapsid animal models.

    abstract：:The Duvernoy's gland secretory proteome of the false coral snake Rhinobothryum bovallii (Costa Rica), unveiled applying bottom-up venomics, comprises a handful of toxins belonging to only three protein families, three-finger toxin (3FTx), cysteine-rich secretory protein (CRISP), and snake venom metalloprotease (PIII-S...

    journal_title：Journal of proteomics

    pub_type： 杂志文章

    doi：10.1016/j.jprot.2020.103882

    authors： Calvete JJ,Bonilla F,Granados-Martínez S,Sanz L,Lomonte B,Sasa M

    更新日期：2020-08-15 00:00:00

  • Comparative proteomic study in serum of patients with primary open-angle glaucoma and pseudoexfoliation glaucoma.

    abstract：UNLABELLED:Alterations in the sera proteins between patients with Primary Open-Angle Glaucoma (POAG), Pseudoexfoliation Glaucoma (PEXG), and healthy controls were identified through a proven approach utilizing equalization of high-abundance serum proteins with ProteoMiner™, two-dimensional fluorescent difference gel el...

    journal_title：Journal of proteomics

    pub_type： 临床试验,杂志文章

    doi：10.1016/j.jprot.2013.12.006

    authors： González-Iglesias H,Álvarez L,García M,Escribano J,Rodríguez-Calvo PP,Fernández-Vega L,Coca-Prados M

    更新日期：2014-02-26 00:00:00

  • Characterizations and proteome analysis of platelet-free plasma-derived microparticles in β-thalassemia/hemoglobin E patients.

    abstract：:Aggregatability and oxidative damage of red blood cells (RBCs), platelet activation and increased amount of blood cells-derived microparticles (MPs) are thought to be the etiologies for the thrombotic risk in thalassemia, but with unclear mechanisms. Here we report cellular origins and increases in number, oxidative s...

    journal_title：Journal of proteomics

    pub_type： 临床试验,杂志文章

    doi：10.1016/j.jprot.2012.06.004

    authors： Chaichompoo P,Kumya P,Khowawisetsut L,Chiangjong W,Chaiyarit S,Pongsakul N,Sirithanaratanakul N,Fucharoen S,Thongboonkerd V,Pattanapanyasat K

    更新日期：2012-12-05 00:00:00

  • Gender proteomics II. Which proteins in sexual organs.

    abstract：:In continuity with the review dealing with differences by gender in non-sexual organs [1], this review collects data on the proteomes of the sexual organs as involved in human reproduction, under both physiological and pathological conditions. It also collects data on the tissue structures and biological fluids typica...

    journal_title：Journal of proteomics

    pub_type： 杂志文章

    doi：10.1016/j.jprot.2017.10.001

    authors： Gianazza E,Miller I,Guerrini U,Palazzolo L,Parravicini C,Eberini I

    更新日期：2018-04-30 00:00:00

  • Identification and quantification of bovine protein lactosylation sites in different milk products.

    abstract：UNLABELLED:The microbiological safety of milk is typically guaranteed by thermal treatments, such as pasteurization and ultra high temperature (UHT) treatment, whereas infant formula (IF) is often produced at even harsher conditions including a drying process. Thermal treatments have raised concerns, as they may denatu...

    journal_title：Journal of proteomics

    pub_type： 杂志文章

    doi：10.1016/j.jprot.2015.07.021

    authors： Milkovska-Stamenova S,Hoffmann R

    更新日期：2016-02-16 00:00:00

  • Recombinant glycoproteins: The impact of cell lines and culture conditions on the generation of protein species.

    abstract：UNLABELLED:Glycosylation is the most complex post-translational modification. Thus, it contributes to versatile chemical compositions of proteins, leading to high amounts of protein species. The structural heterogeneity of glycoproteins was also described by the definition of glycoforms. We therefore introduced a new t...

    journal_title：Journal of proteomics

    pub_type： 杂志文章

    doi：10.1016/j.jprot.2015.08.011

    authors： Rosenlöcher J,Sandig G,Kannicht C,Blanchard V,Reinke SO,Hinderlich S

    更新日期：2016-02-16 00:00:00

  • Unveiling the elusive and exotic: Venomics of the Malayan blue coral snake (Calliophis bivirgata flaviceps).

    abstract：UNLABELLED:The venom proteome of the Malayan blue coral snake, Calliophis bivirgata flaviceps from west Malaysia was investigated by 1D-SDS-PAGE and shotgun-LCMS/MS. A total of 23 proteins belonging to 11 protein families were detected from the venom proteome. For the toxin proteins, the venom consists mainly of phosph...

    journal_title：Journal of proteomics

    pub_type： 杂志文章

    doi：10.1016/j.jprot.2015.11.014

    authors： Tan CH,Fung SY,Yap MK,Leong PK,Liew JL,Tan NH

    更新日期：2016-01-30 00:00:00

  • Efferent intestinal lymph protein responses in nematode-resistant, -resilient and -susceptible lambs under challenge with Trichostrongylus colubriformis.

    abstract：UNLABELLED:The mechanisms underlying resistance to challenge by gastrointestinal nematode parasites in sheep are complex. Using DIGE, we profiled ovine lymph proteins in lambs with host resistance (R), resilience (Ri) or susceptibility (S) to a daily trickle challenge with the nematode Trichostrongylus colubriformis. E...

    journal_title：Journal of proteomics

    pub_type： 杂志文章

    doi：10.1016/j.jprot.2014.07.017

    authors： Bond JJ,Pernthaner A,Zhang K,Rosanowski SM,Clerens S,Bisset SA,Sutherland IA,Koolaard JP,Hein WR

    更新日期：2014-09-23 00:00:00

  • Comparative proteomic analysis reveals that caspase-1 and serine protease may be involved in silkworm resistance to Bombyx mori nuclear polyhedrosis virus.

    abstract：:The silkworm Bombyx mori is of great economic value. The B. mori nuclear polyhedrosis virus (BmNPV) is one of the most common and severe pathogens for silkworm. Although certain immune mechanisms exist in silkworms, most silkworms are still susceptible to BmNPV infection. Interestingly, BmNPV infection resistance in s...

    journal_title：Journal of proteomics

    pub_type： 杂志文章

    doi：10.1016/j.jprot.2012.04.015

    authors： Qin L,Xia H,Shi H,Zhou Y,Chen L,Yao Q,Liu X,Feng F,Yuan Y,Chen K

    更新日期：2012-06-27 00:00:00

  • ITRAQ-based quantitative proteomic analysis of MG63 in response to HIF-1α inducers.

    abstract：:Non-healing fractures constitute a serious clinical problem. HIF-1α is a crucial regulator in response to hypoxia and is proven to be pivotal in bone growth; however, the mechanism still needs further research. In this study, iTRAQ was used to study the effects of two HIF-1α inducers on the expression of proteins in M...

    journal_title：Journal of proteomics

    pub_type： 杂志文章

    doi：10.1016/j.jprot.2019.103558

    authors： Chen C,Hao X,Geng Z,Wang Z

    更新日期：2020-01-16 00:00:00

  • Serological autoantibody profiling of type 1 diabetes by protein arrays.

    abstract：UNLABELLED:The need for biomarkers that illuminate the pathophysiology of type 1 diabetes (T1D), enhance early diagnosis and provide additional avenues for therapeutic intervention is well recognized in the scientific community. We conducted a proteome-scale, two-stage serological AAb screening followed by an independe...

    journal_title：Journal of proteomics

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.1016/j.jprot.2013.10.018

    authors： Miersch S,Bian X,Wallstrom G,Sibani S,Logvinenko T,Wasserfall CH,Schatz D,Atkinson M,Qiu J,LaBaer J

    更新日期：2013-12-06 00:00:00

  • Use of ribosomal proteins as biomarkers for identification of Flavobacterium psychrophilum by MALDI-TOF mass spectrometry.

    abstract：:Matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF-MS) is a rapid methodology for identification of bacteria that is increasingly used in diagnostic laboratories. This work aimed at evaluating the potential of MALDI-TOF-MS for identification of the main serotypes of Flavobacterium ...

    journal_title：Journal of proteomics

    pub_type： 杂志文章

    doi：10.1016/j.jprot.2017.09.007

    authors： Fernández-Álvarez C,Torres-Corral Y,Santos Y

    更新日期：2018-01-06 00:00:00

  • Vitamin D-binding protein as a biomarker of active disease in acute intermittent porphyria.

    abstract：UNLABELLED:Acute intermittent porphyria (AIP) is an autosomal dominant metabolic disorder caused by a deficiency of hepatic porphobilinogen deaminase (PBGD). The disease is characterized by life threatening acute neurovisceral attacks. The aim of this study was to identify metabolites secreted by the hepatocytes that r...

    journal_title：Journal of proteomics

    pub_type： 临床试验,杂志文章

    doi：10.1016/j.jprot.2015.05.004

    authors： Serrano-Mendioroz I,Sampedro A,Mora MI,Mauleón I,Segura V,Enríquez de Salamanca R,Harper P,Sardh E,Corrales FJ,Fontanellas A

    更新日期：2015-09-08 00:00:00

  • The Drosophila melanogaster sperm proteome-II (DmSP-II).

    abstract：:Advances in mass spectrometry technology, high-throughput proteomics and genome annotations have resulted in significant increases in our molecular understanding of sperm composition. Using improved separation and detection methods and an updated genome annotation, a re-analysis of the Drosophila melanogaster sperm pr...

    journal_title：Journal of proteomics

    pub_type： 杂志文章

    doi：10.1016/j.jprot.2010.09.002

    authors： Wasbrough ER,Dorus S,Hester S,Howard-Murkin J,Lilley K,Wilkin E,Polpitiya A,Petritis K,Karr TL

    更新日期：2010-10-10 00:00:00

  • Nuclear proteome analysis reveals a role of Vav1 in modulating RNA processing during maturation of tumoral promyelocytes.

    abstract：:Vav1 is a key molecule in the ATRA-induced acquisition of a mature phenotype by tumoral myeloid precursors. Since ATRA acts throughout events that require extensive changes of nuclear architecture and activity and considering that Vav1 accumulates inside the nuclear compartment of differentiating APL-derived cells, th...

    journal_title：Journal of proteomics

    pub_type： 杂志文章

    doi：10.1016/j.jprot.2011.08.005

    authors： Bertagnolo V,Grassilli S,Petretto A,Lambertini E,Astati L,Bruschi M,Brugnoli F,Nika E,Candiano G,Piva R,Capitani S

    更新日期：2011-12-21 00:00:00

  • Elucidation of the dynamic nature of interactome networks: A practical tutorial.

    abstract：:Considering that proteins are usually engaged in complex and dynamic networks of interactions to exert their activity, a way to understand proteins' functions and the molecular mechanisms in which those proteins are involved, is by studying their interactome. In this sense, this tutorial presents a simple pipeline for...

    journal_title：Journal of proteomics

    pub_type： 杂志文章,评审

    doi：10.1016/j.jprot.2017.04.011

    authors： Anjo SI,Martins-Marques T,Pereira P,Girão H,Manadas B

    更新日期：2018-01-16 00:00:00

  • Coupling of gel-based 2-DE and 1-DE shotgun proteomics approaches to dig deep into the leaf senescence proteome of Glycine max.

    abstract：UNLABELLED:Leaf senescence is the last stage of leaf development that re-mobilizes nutrients from the source to sink. Here, we have utilized the soybean as a model system to unravel senescence-associated proteins (SAPs). A comparative proteomics approach was used at two contrasting stages of leaf development, namely ma...

    journal_title：Journal of proteomics

    pub_type： 杂志文章

    doi：10.1016/j.jprot.2016.07.025

    authors： Gupta R,Lee SJ,Min CW,Kim SW,Park KH,Bae DW,Lee BW,Agrawal GK,Rakwal R,Kim ST

    更新日期：2016-10-04 00:00:00

  • Quantitative proteomics analysis of differentially expressed proteins in ruptured and unruptured cerebral aneurysms by iTRAQ.

    abstract：:The underlying pathophysiological mechanisms involved in cerebral aneurysms rupture remain unclear. This study was performed to investigate the differentially expressed proteins between ruptured and unruptured aneurysms using quantitative proteomics. The aneurysmal walls of six ruptured aneurysms and six unruptured an...

    journal_title：Journal of proteomics

    pub_type： 杂志文章

    doi：10.1016/j.jprot.2018.05.001

    authors： Jiang P,Wu J,Chen X,Ning B,Liu Q,Li Z,Li M,Yang F,Cao Y,Wang R,Wang S

    更新日期：2018-06-30 00:00:00

  • Cross-talk between α7 nAchR and NMDAR revealed by protein profiling.

    abstract：:Functional regulation of NMDA receptor (NMDAR) by the activation of α7 nicotinic acetylcholine receptor (α7nAChR) has been reported, although the molecular signaling pathway underlying this process remains largely unknown. We employed a label-free quantitative proteomics approach to identify potential intracellular mo...

    journal_title：Journal of proteomics

    pub_type： 杂志文章

    doi：10.1016/j.jprot.2015.10.018

    authors： Zhang H,Li T,Li S,Liu F

    更新日期：2016-01-10 00:00:00

  • Comparative iTRAQ proteomics revealed proteins associated with spermatogenic arrest of cattleyak.

    abstract：UNLABELLED:Male infertility of cattleyak due to spermatogenic arrest greatly restricts their effective utilization in yak breeding. Although much work has been done to investigate the mechanisms of spermatogenic arrest, there is no information regarding the differences of protein composition between cattleyak and yak t...

    journal_title：Journal of proteomics

    pub_type： 杂志文章

    doi：10.1016/j.jprot.2016.04.049

    authors： Yu S,Cai X,Sun L,Zuo Z,Mipam T,Cao S,Shen L,Ren Z,Chen X,Yang F,Deng J,Ma X,Wang Y

    更新日期：2016-06-16 00:00:00