Assessment of the humoral immune response to cancer.

Abstract:

:One of the deadly hallmarks of cancer is its ability to prosper within the constraints of the host immune system. Recent advances in immunoproteomics and high-throughput technologies have lead to profiling of the antibody repertoire in cancer patients. This in turn has lead to the identification of tumour associated antigens/autoantibodies. Autoantibodies are extremely attractive and promising biomarker entities, however there has been relatively little discussion on how to interpret the humoral immune response. It may be that autoantibody profiles hold the key to ultimately uncovering neoplastic associated pathways and through the process of immunosculpting the tumour may have yielded an immune response in the early stages of malignant tumour development. The aim of this review is to discuss the utility of the autoantibody response that is elicited as a result of malignancy and discuss the advantages and limitations of autoantibody profiling. This article is part of a Special Issue entitled: Translational Proteomics.

journal_name

J Proteomics

journal_title

Journal of proteomics

authors

Murphy MA,O'Leary JJ,Cahill DJ

doi

10.1016/j.jprot.2012.01.021

subject

Has Abstract

pub_date

2012-08-03 00:00:00

pages

4573-9

issue

15

eissn

1874-3919

issn

1876-7737

pii

S1874-3919(12)00049-8

journal_volume

75

pub_type

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