Abstract：
UNLABELLED:Obstructive sleep apnea syndrome (OSAS) is one of the most complex disorders of sleep; it involves several genetic factors that contribute to the phenotype. Serotonin (5-HT) regulates a variety of visceral and physiological functions, including sleep. Gene 5-HTR2A polymorphisms may change the transcription of several receptors in the serotoninergic system, thereby contributing to OSAS. AIM:To investigate the prevalence of T102C and -1438G/A polymorphisms in the 5-HTR2A gene of patients with and without OSAS. MATERIAL AND METHOD:A molecular study of 100 index-cases and 100 controls of both genders. DNA was extracted from blood leukocytes samples and the regions that enclose both polymorphisms were amplified with PCR-RFLP. STUDY DESIGN:A cross-sectional case study. RESULTS:There was a significant prevalence of males in index cases compared to controls (p<0.0001). No significant genotypic differences between cases and controls were found in T102C polymorphisms (p=1.000).There were significant differences between the AA genotype of -1438G/A polymorphisms and patients with OSAS (OR:2.3; CI95%:1.20-4.38, p=0.01). CONCLUSION:Serotonergic mechanisms may be related to OSAS. There were no differences in the prevalence of T102C polymorphisms in patients with OSAS and the control group. There is evidence of an association between the -1438G /A polymorphism and OSAS.
journal_name
Braz J Otorhinolaryngoljournal_title
Brazilian journal of otorhinolaryngologyauthors
Piatto VB,Carvalho TB,De Marchi NS,Molina FD,Maniglia JVdoi
10.1590/s1808-86942011000300013subject
Has Abstractpub_date
2011-06-01 00:00:00pages
348-55issue
3eissn
1808-8694issn
1808-8686pii
S1808-8694(15)30864-8journal_volume
77pub_type
杂志文章abstract：INTRODUCTION:Bifid uvula is a frequently observed anomaly in the general population and can be regarded as a marker for submucous cleft palate. OBJECTIVE:In this study aimed to determine the frequency of bifid uvula and submucous cleft palate and their relationship with oral clefts in a Brazilian population. METHODS:...
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pub_type： 杂志文章,多中心研究,随机对照试验
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更新日期：2010-07-01 00:00:00
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journal_title：Brazilian journal of otorhinolaryngology
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journal_title：Brazilian journal of otorhinolaryngology
pub_type： 杂志文章
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更新日期：2018-01-01 00:00:00
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journal_title：Brazilian journal of otorhinolaryngology
pub_type： 杂志文章
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更新日期：2019-01-01 00:00:00
