Abstract：
UNLABELLED:p53 tumoral suppressor gene harbors a functional polymorphism which codes either arginine (Arg) or proline (Pro) in the protein p53 of codon 72. Such polymorphism has been associated with the development or prognosis of head and neck squamous cell carcinoma (HNSCC). AIM:we assessed codon 72 p53 allelic frequencies and genotypes in HNSCC Iranian patients. STUDY DESIGN:Case Study. MATERIALS AND METHODS:a total of 132 HNSCC patients and 123 healthy controls were genotyped. DNA source was from mononuclear cells of the peripheral blood. DNA amplification was done by means of the allele-specific polymerase chain reaction. RESULTS:genotypes and allele distribution were not significantly different between patients and controls. Moreover, no statistically significant association was found between the 72 and p53 codon tumor location, gender or age at the time of diagnosis. However, the Pro/Pro genotype was significantly increase in stage IV patients (30.8%) when compared to stages I-III of the disease (11.1%) (p=0.03), and a significantly higher percentage of patients with the Pro allele had and a risk increase in stage IV disease (OR=2.2, 95% CI=1.2-4.2, p=0.01). CONCLUSION:data revealed that the p53 polymorphism do not impact the risk of HNSCC in Iranians, nonetheless, it can affect tumor progression to a higher tumor stage.
journal_name
Braz J Otorhinolaryngoljournal_title
Brazilian journal of otorhinolaryngologyauthors
Mojtahedi Z,Hashemi SB,Khademi B,Karimi M,Haghshenas MR,Fattahi MJ,Ghaderi Asubject
Has Abstractpub_date
2010-05-01 00:00:00pages
316-20issue
3eissn
1808-8694issn
1808-8686pii
S1808-8694(15)30413-4journal_volume
76pub_type
杂志文章abstract：INTRODUCTION:The diagnostic approach to patients with isolated asymptomatic cervical lymphadenopathy varies between excisional biopsy and follow-up. When the anamnesis, physical examination, laboratory and imaging findings are not sufficient to identify the etiology, an excisional biopsy is performed for the differenti...
journal_title：Brazilian journal of otorhinolaryngology
pub_type： 杂志文章
doi：10.1016/j.bjorl.2020.06.012
更新日期：2020-08-01 00:00:00
abstract：UNLABELLED:Tympanoplasty is done to eradicate ear pathology and to restore the conductive hearing mechanism (eardrum and ossicles). Some patients, however, do not tolerate tinnitus and question physicians about the results of surgery when tinnitus persists. AIM:to evaluate the progression of tinnitus in patients with ...
journal_title：Brazilian journal of otorhinolaryngology
pub_type： 杂志文章
doi：10.1016/s1808-8694(15)30083-5
更新日期：2007-05-01 00:00:00
abstract：INTRODUCTION:Imaging studies have hystorically been used to support the clinical otorhinolaryngological evaluation of the upper respiratory tract for the diagnosis of obstructive causes of oral breathing. OBJECTIVE:The objective of this study was to compare 3D volumetric measurements of nasal cavity, nasopharynx and o...
journal_title：Brazilian journal of otorhinolaryngology
pub_type： 杂志文章
doi：10.1016/j.bjorl.2018.01.006
更新日期：2019-01-01 00:00:00
abstract：INTRODUCTION:Cleft lip and/or palate (CL/P) represent the most common congenital anomalies of the face. OBJECTIVE:To evaluate the prevalence of depressive symptoms in children and adolescents with nonsyndromic cleft lip and/or palate (nsCL/P). METHODS:We conducted an observational, case-control study, with a case stu...
journal_title：Brazilian journal of otorhinolaryngology
pub_type： 杂志文章
doi：10.1016/j.bjorl.2015.01.004
更新日期：2015-03-01 00:00:00
abstract：UNLABELLED:Epistaxis is the main otorhinolaryngology emergency and, in severe cases, it can lead to hemodynamic instability and be life threatening. AIM:To evaluate factors involved in epistaxis resistant to nasal packing that needed surgical treatment, as well as post-surgical results. MATERIAL AND METHODS:Retrospec...
journal_title：Brazilian journal of otorhinolaryngology
pub_type： 杂志文章
doi：
更新日期：2009-05-01 00:00:00
abstract：INTRODUCTION:There is a strong association between vertigo and migraine. Vestibular migraine (VM) was described in 1999, and diagnostic criteria were proposed in 2001 and revised in 2012. OBJECTIVE:To compare the diagnostic criteria for VM proposed in 2001 with 2012 criteria with respect to their diagnostic power and ...
journal_title：Brazilian journal of otorhinolaryngology
pub_type： 杂志文章
doi：10.1016/j.bjorl.2015.07.007
更新日期：2015-09-01 00:00:00
abstract：INTRODUCTION:Abused children and adolescents are exposed to factors that can trigger vocal changes. OBJECTIVE:This study aimed to analyze the prevalence of vocal changes in abused children and adolescents, through auditory-perceptual analysis of voice and the study of the association between vocal changes, communicati...
journal_title：Brazilian journal of otorhinolaryngology
pub_type： 杂志文章
doi：10.1016/j.bjorl.2014.11.006
更新日期：2015-01-01 00:00:00
abstract：INTRODUCTION:Serum level of high-mobility group box 1 protein is reportedly correlated with the severity of obstructive sleep apnea. OBJECTIVE:We tried to evaluate the possibility of using the serum high-mobility group box 1 protein level as a biologic marker in obstructive sleep apnea patients. METHODS:We generated ...
journal_title：Brazilian journal of otorhinolaryngology
pub_type： 杂志文章
doi：10.1016/j.bjorl.2020.11.019
更新日期：2021-01-02 00:00:00
abstract：UNLABELLED:Hearing aid fitting involves numerous issues that must be investigated - from the device supply all the way to results achieved with it in order to improve its results in planning Auditory Health Care. AIMS:to verify difficulties related to device use, batteries and ear molds handling, the very characterist...
journal_title：Brazilian journal of otorhinolaryngology
pub_type： 杂志文章
doi：10.1016/S1808-8694(15)31170-8
更新日期：2007-11-01 00:00:00
abstract：:Fanconi's anemia is a rare autosomal recessive disorder characterized by congenital malformation, bone marrow failure and genomic instability, with a predisposition to develop malignancies, especially the leukemias and upper aerodigestive tract tumors. Due to inherent characteristics to this syndrome, the treatment of...
journal_title：Brazilian journal of otorhinolaryngology
pub_type： 杂志文章,评审
doi：10.1016/s1808-8694(15)31054-5
更新日期：2006-11-01 00:00:00
abstract：UNLABELLED:Myringosclerosis is characterized by hyaline changes of the lamina propria of the tympanic membrane. Experimental studies have used otomicroscopy or histology to evaluate myringosclerosis in animals, but they do not correlate precisely these two methods. AIM:The present study evaluates the accuracy of otomi...
journal_title：Brazilian journal of otorhinolaryngology
pub_type： 杂志文章
doi：10.1016/s1808-8694(15)31272-6
更新日期：2005-09-01 00:00:00
abstract：INTRODUCTION:Studies that assess the upper airways in sleep-related breathing disorders have been performed only in patients with obstructive sleep apnea syndrome who seek medical attention. Therefore, in addition to the need for population studies, there are no data on the orofacial-cervical physical examination in su...
journal_title：Brazilian journal of otorhinolaryngology
pub_type： 杂志文章
doi：10.1016/j.bjorl.2015.05.015
更新日期：2016-07-01 00:00:00
abstract：UNLABELLED:Alloplastic materials can be used together with tissue and structure to close nasal septal perforation. AIM:to test cellulose use in the closure of septal perforation in rabbits and to compare fibrosis, inflammation, vascular congestion and graft integrity. MATERIALS AND METHODS:Fifteen rabbits. The rabbit...
journal_title：Brazilian journal of otorhinolaryngology
pub_type： 杂志文章
doi：
更新日期：2010-07-01 00:00:00
abstract：UNLABELLED:Hearing thresholds are not always predictive of performance in environments with reduced extrinsic redundancy. OBJECTIVE:To investigate the communication disorders reported by adults with normal hearing, and to assess their underlying conditions through behavioral and electrophysiological testing. METHOD:T...
journal_title：Brazilian journal of otorhinolaryngology
pub_type： 杂志文章
doi：10.5935/1808-8694.20130012
更新日期：2013-01-01 00:00:00
abstract：UNLABELLED:Benign Positional Paroxysmal Vertigo (BPPV) is one of the most common vestibular diseases and the active head rotation test one of the most modern methods of vestibular function assessment. AIM:this study aims to verify if the active head rotation test may reveal signs of horizontal and/or vertical vestibul...
journal_title：Brazilian journal of otorhinolaryngology
pub_type： 杂志文章
doi：10.1016/s1808-8694(15)30500-0
更新日期：2009-07-01 00:00:00
abstract：INTRODUCTION:Middle ear adenomatous neuroendocrine tumors are extremely rare neoplasms with epithelial and neuroendocrine differentiation, accounting for fewer than 2% of all middle and inner ear tumors. Universal standard surgical procedures for different stages of these tumors remain elusive due to the limitation of ...
journal_title：Brazilian journal of otorhinolaryngology
pub_type： 杂志文章
doi：10.1016/j.bjorl.2020.05.011
更新日期：2020-06-15 00:00:00
abstract：INTRODUCTION:In order to better understand the pathophysiology of rhinosinusitis, several attempts have been made to create the disease in an animal model. Among the studied rodents each has its advantages and disadvantages. Rabbits are considered more appropriate for studies that require surgical manipulation or invas...
journal_title：Brazilian journal of otorhinolaryngology
pub_type： 杂志文章,评审
doi：10.1016/j.bjorl.2014.07.011
更新日期：2014-09-01 00:00:00
abstract：BACKGROUND:Amyloidosis is the term applied to a diverse group of disorders that share the features of deposition of amorphous, extracellular material at various sites. Amyloid deposits may occur locally or may involve various organs, resulting number of clinical manifestations. Amyloidosis of the head and neck is rare ...
journal_title：Brazilian journal of otorhinolaryngology
pub_type：
doi：10.1016/j.bjorl.2020.11.011
更新日期：2020-12-19 00:00:00
abstract：INTRODUCTION:Leiomyosarcoma is a tumor which is rarely seen in the thyroid gland. The diagnosis may be difficult and the treatment is controversial. OBJECTIVE:The objective of the study is to review the literature about a rare malignant disease of the thyroid gland which has high mortality. METHODS:Two cases of thyro...
journal_title：Brazilian journal of otorhinolaryngology
pub_type： 杂志文章,评审
doi：10.1016/j.bjorl.2015.11.020
更新日期：2016-01-01 00:00:00
abstract：INTRODUCTION:Cochlear Implant is a sensory prosthesis capable of restoring hearing in patients with severe or profound bilateral sensorineural hearing loss. OBJECTIVE:To evaluate if there is a better side to be implanted in post-lingual patients. METHODS:Retrospective longitudinal study. Participants were 40 subjects...
journal_title：Brazilian journal of otorhinolaryngology
pub_type： 杂志文章
doi：10.1016/j.bjorl.2017.06.012
更新日期：2018-01-01 00:00:00
abstract：UNLABELLED:Hearing represents the main source for acquisition of language and speaking skills in childhood. In the first months of life, the hearing impaired child is deprived of sound stimulation in the most important period of development, and consequently, might present emotional, social and linguistic disorders. Th...
journal_title：Brazilian journal of otorhinolaryngology
pub_type： 杂志文章
doi：10.1016/s1808-8694(15)30031-8
更新日期：2006-01-01 00:00:00
abstract：UNLABELLED:Caloric testing is an otoneurologic evaluation of the status of the vestibular-ocular reflex; it allows an evaluation of each labyrinth separately. The main aspects on the use and interpretation of caloric testing are reviewed. METHOD:A systematic review of papers published in the past one hundred years on ...
journal_title：Brazilian journal of otorhinolaryngology
pub_type： 杂志文章,评审
doi：10.1016/s1808-8694(15)30580-2
更新日期：2008-05-01 00:00:00
abstract：INTRODUCTION:Children may require tracheostomy due to many different health conditions. Over the last 40 years, indications of tracheostomy have endorsed substantial modifications. OBJECTIVE:To evaluate pediatric patients warranted tracheostomy at our Hospital, in regard to their indications, associated comorbidities,...
journal_title：Brazilian journal of otorhinolaryngology
pub_type： 杂志文章
doi：10.1016/j.bjorl.2016.08.002
更新日期：2017-01-01 00:00:00
abstract：INTRODUCTION:Severe obstructive sleep apnea is associated with increased QT corrected interval dispersion and continuous positive airway pressure is thought to improve this arrhythmogenic marker. OBJECTIVE:The aim of the study was to determine the decrease of ratio of cardiovascular risk in patients with obstructive s...
journal_title：Brazilian journal of otorhinolaryngology
pub_type： 杂志文章
doi：10.1016/j.bjorl.2017.03.005
更新日期：2018-01-01 00:00:00
abstract：UNLABELLED:Utriculostomy is a new surgical alternative for Ménière's disease. The basis of this procedure is that the outcome of an electrocautery-induced utricular trauma does not affect cochlear function. However, a demonstration of the hypothesis that this approach to the utricle would preserve hearing is still pend...
journal_title：Brazilian journal of otorhinolaryngology
pub_type： 杂志文章
doi：
更新日期：2012-04-01 00:00:00
abstract：UNLABELLED:Previous studies suggest that there is an excellent correlation between the morphology and dimensions of ear structures in sheep and human beings. AIM:To analyze and describe the histology of structures inside the temporal bone in sheep. MATERIAL AND METHODS:A total of 307 slides obtained from vertical and...
journal_title：Brazilian journal of otorhinolaryngology
pub_type： 杂志文章
doi：10.1590/s1808-86942011000300003
更新日期：2011-06-01 00:00:00
abstract：INTRODUCTION:Methicillin-resistant staphylococcus aureus is an emerging problem for the treatment of chronic suppurative otitis media, and also for pediatric tympanostomy tube otorrhea. To date, there are no effective topical antibiotic drugs to treat methicillin-resistant staphylococcus aureus otorrhea. OBJECTIVE:In ...
journal_title：Brazilian journal of otorhinolaryngology
pub_type： 杂志文章
doi：10.1016/j.bjorl.2017.05.002
更新日期：2018-01-01 00:00:00
abstract：INTRODUCTION:The real number of COVID-19 cases may be underestimated since several countries have difficulty offering laboratory tests for all the population. Therefore, finding a symptom with a high predictive value would help in diagnostic and isolation strategies. OBJECTIVE:To correlate the sudden loss of the sense...
journal_title：Brazilian journal of otorhinolaryngology
pub_type： 杂志文章
doi：10.1016/j.bjorl.2020.05.002
更新日期：2020-01-01 00:00:00
abstract：INTRODUCTION:Knowledge of the characteristics related to profound hearing loss is a matter of great importance, as it allows for the etiological and prognostic identification and strategic planning for public health interventions. OBJECTIVE:To assess the different etiologies of hearing loss, age at diagnosis of the he...
journal_title：Brazilian journal of otorhinolaryngology
pub_type： 杂志文章
doi：10.1016/j.bjorl.2014.05.011
更新日期：2014-07-01 00:00:00
abstract：INTRODUCTION:The association between uterine cervix and anogenital carcinomas and human papillomavirus, HPV, is well established, however the involvement of this virus in the development of oral squamous cell carcinomas remains controversial. OBJECTIVES:To evaluate the relationship between HPV infection and oral squam...
journal_title：Brazilian journal of otorhinolaryngology
pub_type： 杂志文章,评审
doi：10.1016/j.bjorl.2020.10.017
更新日期：2020-11-29 00:00:00
