Abstract:
INTRODUCTION:Serum level of high-mobility group box 1 protein is reportedly correlated with the severity of obstructive sleep apnea. OBJECTIVE:We tried to evaluate the possibility of using the serum high-mobility group box 1 protein level as a biologic marker in obstructive sleep apnea patients. METHODS:We generated a chronic intermittent hypoxia murine model that reflected human obstructive sleep apnea. Obstructive sleep apnea patients who underwent polysomnography were prospectively enrolled. Serum samples were obtained from mice and obstructive sleep apnea patients, and the serum high-mobility group box1 protein level was measured by enzyme-linked immunosorbent assay. RESULTS:Serum high-mobility group box 1 protein level was 56.16 ± 30.33 ng/mL in chronic intermittent hypoxia and 18.63 ± 6.20 ng/mL in control mice (p < 0.05). The mean apnea-hypopnea index and respiratory disturbance index values of enrolled obstructive sleep apnea patients were 50.35 ± 27.96 and 51.56 ± 28.53, respectively, and the mean serum high-mobility group box 1 protein level was 30.13 ± 19.97 ng/mL. The apnea-hypopnea index and respiratory disturbance index were not significantly correlated with the serum high-mobility group box 1 protein level (p > 0.05). Instead, this protein level was significantly correlated with lowest arterial oxygen concentration (SaO2) (p < 0.05). CONCLUSION:High-mobility group box 1 protein may be involved in the pathogenesis of obstructive sleep apnea, and the possibility of this protein being a useful biologic marker in obstructive sleep apnea should be further evaluated.
journal_name
Braz J Otorhinolaryngoljournal_title
Brazilian journal of otorhinolaryngologyauthors
Min HJ,Park JS,Kim KS,Kang M,Seo JH,Yoon JH,Kim CH,Cho HJdoi
10.1016/j.bjorl.2020.11.019subject
Has Abstractpub_date
2021-01-02 00:00:00eissn
1808-8694issn
1808-8686pii
S1808-8694(20)30243-3pub_type
杂志文章abstract:INTRODUCTION:The Montgomery T-tube is a device used as a combined tracheal stent and tracheostomy tube to prevent post-operative tracheal stenosis. OBJECTIVES:The purpose of this retrospective study is to evaluate the outcome following Montgomery T-tube stenting performed in for neck and airway injury in patients with...
journal_title:Brazilian journal of otorhinolaryngology
pub_type: 杂志文章
doi:10.1016/j.bjorl.2020.06.009
更新日期:2020-07-27 00:00:00
abstract:INTRODUCTION:Tinnitus is sound perception in the absence of a sound source. Changes in parameters of latency and amplitude on the auditory event related potentials or long latency potentials waves have been cited in tinnitus patients when compared to a control group. OBJECTIVE:To perform an assessment of scientific ev...
journal_title:Brazilian journal of otorhinolaryngology
pub_type: 杂志文章
doi:10.1016/j.bjorl.2019.09.005
更新日期:2020-01-01 00:00:00
abstract:UNLABELLED:The association between hearing and balance disorders with migraine is known since the times of the ancient Greeks, when Aretaeus from Cappadocia in 131 B.C, made an accurate and detailed description of this occurrence during a migraine episode. We present a broad review of migraine neurotological manifestat...
journal_title:Brazilian journal of otorhinolaryngology
pub_type: 杂志文章,评审
doi:10.1016/s1808-8694(15)30611-x
更新日期:2008-07-01 00:00:00
abstract:UNLABELLED:Among the methods for assessing swallowing sounds - videofluoroscopy modified barium study, fiberoptic swallowing endoscopy, neck auscultation through a microphone, accelerometer and, more recently, the Doppler sonar - we have chosen the latter. AIM:to analyze swallowing sounds by cervical auscultation usin...
journal_title:Brazilian journal of otorhinolaryngology
pub_type: 杂志文章
doi:
更新日期:2009-09-01 00:00:00
abstract:UNLABELLED:Benign Positional Paroxysmal Vertigo (BPPV) is one of the most common vestibular diseases and the active head rotation test one of the most modern methods of vestibular function assessment. AIM:this study aims to verify if the active head rotation test may reveal signs of horizontal and/or vertical vestibul...
journal_title:Brazilian journal of otorhinolaryngology
pub_type: 杂志文章
doi:10.1016/s1808-8694(15)30500-0
更新日期:2009-07-01 00:00:00
abstract:UNLABELLED:p53 tumoral suppressor gene harbors a functional polymorphism which codes either arginine (Arg) or proline (Pro) in the protein p53 of codon 72. Such polymorphism has been associated with the development or prognosis of head and neck squamous cell carcinoma (HNSCC). AIM:we assessed codon 72 p53 allelic freq...
journal_title:Brazilian journal of otorhinolaryngology
pub_type: 杂志文章
doi:
更新日期:2010-05-01 00:00:00
abstract::Created in 2007, COMUSA is a multiprofessional committee comprising speech therapy, otology, otorhinolaryngology and pediatrics with the aim of debating and countersigning auditory health actions for neonatal, lactating, preschool and school children, adolescents, adults and elderly persons. COMUSA includes representa...
journal_title:Brazilian journal of otorhinolaryngology
pub_type: 杂志文章
doi:
更新日期:2010-01-01 00:00:00
abstract:UNLABELLED:Exposure to ototoxic chemical products in the presence or absence of noise can cause irreversible injury to the hearing of workers for a significantly short period of exposure period. AIM:to perform a comparative study, through audiometric tests, in workers exposed to noise only and noise associated with ch...
journal_title:Brazilian journal of otorhinolaryngology
pub_type: 杂志文章
doi:10.1016/s1808-8694(15)30831-4
更新日期:2009-01-01 00:00:00
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journal_title:Brazilian journal of otorhinolaryngology
pub_type: 杂志文章
doi:10.1016/j.bjorl.2019.12.007
更新日期:2020-01-25 00:00:00
abstract:INTRODUCTION:Rhinosinusitis constitutes an important health problem, with significant interference in personal, professional, and social functioning. This study presents the validation process of the Portuguese version of the RhinoQOL, to be used as a routine procedure in the assessment of patients with chronic rhinosi...
journal_title:Brazilian journal of otorhinolaryngology
pub_type: 杂志文章
doi:10.1016/j.bjorl.2015.08.015
更新日期:2015-11-01 00:00:00
abstract:BACKGROUND:Amyloidosis is the term applied to a diverse group of disorders that share the features of deposition of amorphous, extracellular material at various sites. Amyloid deposits may occur locally or may involve various organs, resulting number of clinical manifestations. Amyloidosis of the head and neck is rare ...
journal_title:Brazilian journal of otorhinolaryngology
pub_type:
doi:10.1016/j.bjorl.2020.11.011
更新日期:2020-12-19 00:00:00
abstract:INTRODUCTION:Adenotonsillectomy is an invasive surgical procedure, which may encourage the search for information by the lay population through online search engines. The quality of this information, however, requires an evaluation due to the wide diversity of the available content. OBJECTIVE:To evaluate the quality, ...
journal_title:Brazilian journal of otorhinolaryngology
pub_type: 杂志文章
doi:10.1016/j.bjorl.2019.06.012
更新日期:2019-07-27 00:00:00
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journal_title:Brazilian journal of otorhinolaryngology
pub_type: 杂志文章
doi:10.1016/s1808-8694(15)30129-4
更新日期:2007-09-01 00:00:00
abstract:INTRODUCTION:There is evidence that trauma caused by snoring in the pharynx could result in dysphagia in patients with obstructive sleep apnea, but the literature is still scarce to define the factors associated with the presence of dysphagia in these patients. AIM:To analyze the occurrence of dysphagia and its clinic...
journal_title:Brazilian journal of otorhinolaryngology
pub_type: 杂志文章
doi:10.1016/j.bjorl.2019.10.004
更新日期:2019-11-15 00:00:00
abstract:INTRODUCTION:Cartilage is the grafting material of choice for certain disorders of the middle ear. The indications for its routine use remain controversial due to the possible detrimental effect on post-operative hearing. OBJECTIVE:The present study was carried out to report a personal experience with "tragal cartilag...
journal_title:Brazilian journal of otorhinolaryngology
pub_type: 杂志文章
doi:10.1016/j.bjorl.2018.12.006
更新日期:2020-01-01 00:00:00
abstract:UNLABELLED:Saccades are part of the electrooculography tests battery. The cerebellum has important connections with the brainstem and thalamic structures involved in the generation of saccades. AIM:to study saccadic movements in subjects with cerebellar disorders. STUDY METHOD:Prospective clinical study. MATERIALS A...
journal_title:Brazilian journal of otorhinolaryngology
pub_type: 杂志文章
doi:
更新日期:2010-01-01 00:00:00
abstract:INTRODUCTION:Severe obstructive sleep apnea is associated with increased QT corrected interval dispersion and continuous positive airway pressure is thought to improve this arrhythmogenic marker. OBJECTIVE:The aim of the study was to determine the decrease of ratio of cardiovascular risk in patients with obstructive s...
journal_title:Brazilian journal of otorhinolaryngology
pub_type: 杂志文章
doi:10.1016/j.bjorl.2017.03.005
更新日期:2018-01-01 00:00:00
abstract:UNLABELLED:The immunodeficiency state in HIV infected patients has been the cause of severe episodes of Recurrent Aphthous Stomatitis (RAS). AIM:Our study aims to establish correlation between the manifestations of RAS and the immunosuppression state caused by HIV infection, through counting of CD4+ cells, CD8+ cells,...
journal_title:Brazilian journal of otorhinolaryngology
pub_type: 杂志文章
doi:10.1016/s1808-8694(15)31209-x
更新日期:2005-07-01 00:00:00
abstract:INTRODUCTION:Imaging studies have hystorically been used to support the clinical otorhinolaryngological evaluation of the upper respiratory tract for the diagnosis of obstructive causes of oral breathing. OBJECTIVE:The objective of this study was to compare 3D volumetric measurements of nasal cavity, nasopharynx and o...
journal_title:Brazilian journal of otorhinolaryngology
pub_type: 杂志文章
doi:10.1016/j.bjorl.2018.01.006
更新日期:2019-01-01 00:00:00
abstract:INTRODUCTION:The standard therapy for obstructive sleep apnea syndrome (OSAS) is continuous positive airway pressure (CPAP), but its correct and frequent use is essential to control the disease. PURPOSE:To analyze adherence to CPAP among patients with OSAS treated in a multidisciplinary outpatient clinic of a public t...
journal_title:Brazilian journal of otorhinolaryngology
pub_type: 杂志文章
doi:10.5935/1808-8694.20140027
更新日期:2014-04-01 00:00:00
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journal_title:Brazilian journal of otorhinolaryngology
pub_type: 杂志文章,评审
doi:10.1590/s1808-86942011000200018
更新日期:2011-03-01 00:00:00
abstract:INTRODUCTION:Tympanoplasty is performed to close the tympanic membrane perforation and recover the hearing level of patients with non-suppurative chronic otitis media. Endoscopic tympanoplasty has recently been increasingly preferred by ear nose and throat surgeons to treat tympanic membrane perforations. OBJECTIVE:Th...
journal_title:Brazilian journal of otorhinolaryngology
pub_type: 杂志文章
doi:10.1016/j.bjorl.2018.12.012
更新日期:2020-01-01 00:00:00
abstract:UNLABELLED:Individuals often seek help with foreign bodies (FB) in their ears, noses, and throats. Proper recognition, study, and management of foreign bodies is required to prevent complications. OBJECTIVE:To analyze the profile of the patients seen for FB at a reference otorhinolaryngology emergency care unit betwee...
journal_title:Brazilian journal of otorhinolaryngology
pub_type: 杂志文章
doi:10.5935/1808-8694.20130128
更新日期:2013-11-01 00:00:00
abstract:INTRODUCTION:Treatments used in head and neck cancer greatly impact the physical, psychological and functional state of patients. Evaluation of quality of life has become an integral part of the treatment. OBJECTIVE:This retrospective study evaluates features involved in changes in quality of life after major surgery ...
journal_title:Brazilian journal of otorhinolaryngology
pub_type: 杂志文章
doi:10.1016/j.bjorl.2015.10.013
更新日期:2016-09-01 00:00:00
abstract:UNLABELLED:Laryngeal microsurgery is a kind of treatment for various laryngeal diseases. Because of the need of long instruments and delicate maneuvers, involuntary movements represent relevant difficulty and may be responsible for unintended post-operative results. AIM:This study proposes a new stabilization system, ...
journal_title:Brazilian journal of otorhinolaryngology
pub_type: 杂志文章
doi:
更新日期:2010-09-01 00:00:00
abstract:INTRODUCTION:Despite recent advancement in the prediction of cochlear implant outcome, the benefit of bilateral procedures compared to bimodal stimulation and how we predict speech perception outcomes of sequential bilateral cochlear implant based on bimodal auditory performance in children remain unclear. OBJECTIVES:...
journal_title:Brazilian journal of otorhinolaryngology
pub_type: 杂志文章
doi:10.1016/j.bjorl.2018.04.009
更新日期:2019-01-01 00:00:00
abstract:UNLABELLED:The neck is vulnerable to trauma because of vital structures and possible major injuries with high morbidity and mortality rates. AIM:To evaluate the outcome in patients with penetrating cervical wounds. METHODS:The medical registries of 39 patients were analyzed retrospectively from 2001 to 2009. Penetrat...
journal_title:Brazilian journal of otorhinolaryngology
pub_type: 杂志文章
doi:10.1590/s1808-86942011000100020
更新日期:2011-01-01 00:00:00
abstract:UNLABELLED:Graves's disease is the most common cause of hyperthyroidism. There are three current therapeutic options: anti-thyroid medication, surgery, and radioactive iodine (I 131). There are few data in the literature regarding the effects of radioiodine therapy on the larynx and voice. The aim and the AIM:os this ...
journal_title:Brazilian journal of otorhinolaryngology
pub_type: 杂志文章
doi:10.1016/s1808-8694(15)31092-2
更新日期:2008-03-01 00:00:00
abstract:UNLABELLED:To setup an experimental model is the first step to study neural regeneration. AIM:Setting up an experimental model on facial nerve regeneration. MATERIAL AND METHODS:Wistar rats with complete sectioning and suturing of the extratemporal facial nerve trunk; with a behavioral and histological analysis for 9...
journal_title:Brazilian journal of otorhinolaryngology
pub_type: 杂志文章
doi:
更新日期:2006-11-01 00:00:00
abstract:UNLABELLED:The graphic obtained by acoustic rhinometry in Caucasian adult individuals with no nasal affections clearly shows two notches at the beginning of the nasal echogram. However, there are controversies in the literature concerning their anatomic correlation. AIM:The aim of this study was to obtain data that wo...
journal_title:Brazilian journal of otorhinolaryngology
pub_type: 杂志文章
doi:10.1016/s1808-8694(15)31303-3
更新日期:2005-03-01 00:00:00