Abstract：
INTRODUCTION:The biological processes involved in noise-induced hearing loss (NIHL) are still unclear. The involvement of inflammation in this condition has been suggested. OBJECTIVE:To investigate the association between interleukin - 6 (IL-6) polymorphism and susceptibility to NIHL. METHODS:This was a cross-sectional study with a sample of 191 independent elderly individuals aged >60 years of age. Information on exposure to occupational noise was obtained by interviews. Audiological evaluation was performed using pure tone audiometry and genotyped through PCR by restriction fragment length polymorphism - PCR-RFLP. Data were analyzed using the chi-square test and the odds ratio (OR), with the significance level set at 5%. RESULTS:Among elderly with hearing loss (78.0%), 18.8% had a history of exposure to occupational noise. There was a statistically significant association between the genotype frequencies of the IL-6 -174 and NIHL. The elderly with the CC genotype were less likely to have hearing loss due to occupational noise exposure when compared to those carrying the GG genotype (OR=0.0124; 95% CI 0.0023-0.0671; p<0.001). CONCLUSION:This study suggests there is an association of polymorphisms in the IL-6 gene at position - G174C with susceptibility to noise-induced hearing loss.
journal_name
Braz J Otorhinolaryngoljournal_title
Brazilian journal of otorhinolaryngologyauthors
Braga MP,Maciel SM,Marchiori LL,Poli-Frederico RCdoi
10.1016/j.bjorl.2014.07.001subject
Has Abstractpub_date
2014-09-01 00:00:00pages
373-8issue
5eissn
1808-8694issn
1808-8686pii
S1808-8694(14)00071-8journal_volume
80pub_type
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