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The effects of hyperbaric oxygen therapy upon ototoxic injuries produced by amikacin in guinea pigs.

Abstract：

UNLABELLED:Hyperbaric oxygen therapy (HBOT) has enhanced the prevention and treatment of auditory ailments such as ototoxicity. OBJECTIVE:To study the effects of HBOT upon ototoxic injuries produced by amikacin. METHOD:This experimental study included 12 albino guinea pigs, whose auditory function was assessed through distortion product otoacoustic emissions (DPOAEs) and brainstem auditory evoked potentials (BAEPs) before and after the administration of amikacin (600 mg/kg/day) and HBOT sessions (2 ATA, 60 minutes). Morphological features were analyzed through scanning electron microscopy. Subjects were divided into four groups, as follows: group 1 - saline solution + HBOT; group 2 - amikacin for 8 days; group 3 - amikacin + seven days of rest; and group 4 - amikacin + HBOT. RESULTS:Group 1 subjects had preserved function and morphology throughout the experiment; Group 2 subjects had statistically significant levels of hair cell injury and functional impairment; Subjects on groups 3 and 4 had statistically significant functional and morphological impairment after the administration of amikacin, which were still present after the proposed procedures had been carried out. CONCLUSION:Hyperbaric oxygen therapy did not change the cochlear hair cell morphology or the electro-physiological thresholds of the guinea pigs given amikacin.

journal_name

Braz J Otorhinolaryngol

journal_title

Brazilian journal of otorhinolaryngology

authors

Amora Lde A,Murashima Ade A,Rossato M,Moreira MB,Hyppolito MÂ,Fagundes DJ

doi

10.5935/1808-8694.20130060

subject

Has Abstract

pub_date

2013-05-01 00:00:00

pages

342-8

issue

3

eissn

1808-8694

issn

1808-8686

pii

S1808-8694(15)30175-0

journal_volume

79

pub_type

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