Abstract：
INTRODUCTION:Preventing or reversing hearing loss is challenging in Ménière's disease. Betahistine, as a histamine agonist, has been tried in controlling vertigo in patients with Ménière's disease, but its effectiveness on hearing problems is not known. OBJECTIVE:To examine the effect of betahistine on hearing function in not-previously-treated patients with Ménière's disease and to define possible contributors in this regard. METHODS:A total of 200 not-previously-treated patients with definite unilateral Ménière's disease received betahistine by mouth (initial dose, 16mg three times a day; maintenance dose, 24-48mg daily in divided doses). Changes in indicators of hearing status before and six months after treatment were documented. Hearing loss was considered as the mean hearing level >25dB HL at five frequencies. RESULTS:The mean duration of disease was 3.37 years. Six months after treatment the mean hearing level decreased by 6.35dB compared to that at the baseline (p<0.001). Both patients' age and the duration of disease correlated negatively with the improvement in hearing function. Post treatment hearing loss was independently associated with age, the initial hearing level and the chronicity of disease. The corresponding optimal cut-off points for predicating a persistent hearing loss 6 months after treatment were 47 years, 38dB HL, and 1.4 years, respectively. CONCLUSION:Oral betahistine was significantly effective in preventing/reversing hearing deterioration in patients with Ménière's disease. Age, the hearing level on admission, and the disease duration were independent predictors of hearing status after treatment.
journal_name
Braz J Otorhinolaryngoljournal_title
Brazilian journal of otorhinolaryngologyauthors
Seyed Tootoonchi SJ,Ghiasi S,Shadara P,Samani SM,Fouladi DFdoi
10.1016/j.bjorl.2015.08.021subject
Has Abstractpub_date
2016-09-01 00:00:00pages
500-6issue
5eissn
1808-8694issn
1808-8686pii
S1808-8694(15)00234-7journal_volume
82pub_type
杂志文章abstract：INTRODUCTION:Squamous cell carcinoma is the most common neoplasm of the larynx, and its evolution depends on tumor staging. Vascular endothelial growth factor is a marker of angiogenesis, and its expression may be related to increased tumor aggressiveness, as evidenced by the presence of cervical lymphatic metastases. ...
journal_title：Brazilian journal of otorhinolaryngology
pub_type： 杂志文章
doi：10.1016/j.bjorl.2014.08.016
更新日期：2015-01-01 00:00:00
abstract：INTRODUCTION:Sentinel lymph node biopsy is a proven method for staging the neck in patients with early oral cavity squamous cell carcinoma because it results in less comorbidity than the traditional method of selective neck dissection, with the same oncological results. However, the real effect of that method on the qu...
journal_title：Brazilian journal of otorhinolaryngology
pub_type： 杂志文章
doi：10.1016/j.bjorl.2020.11.015
更新日期：2020-12-27 00:00:00
abstract：INTRODUCTION:Total rhinectomy is an uncommon procedure for the treatment of nasal malignancies, usually reserved for locally advanced tumors. There are few case series studying total rhinectomy in the literature, reporting conflicting results about recurrence and metastasis. OBJECTIVE:Evaluate prognosis of total rhine...
journal_title：Brazilian journal of otorhinolaryngology
pub_type： 杂志文章
doi：10.1016/j.bjorl.2019.06.002
更新日期：2020-01-01 00:00:00
abstract：UNLABELLED:Cognitive and emotional factors may affect balance; psychiatric conditions are a common component in patient dizziness. The treatment of patients with vertigo may be affected to a greater degree by the suffering due to this disease than by the severity of organic changes. OBJECTIVE:This study aimed to inves...
journal_title：Brazilian journal of otorhinolaryngology
pub_type： 杂志文章
doi：10.1590/s1808-86942012000100010
更新日期：2012-02-01 00:00:00
abstract：INTRODUCTION:Perceptual evaluation is considered the gold standard to evaluate speech nasality. Several procedures are used to collect and analyze perceptual data, which makes it susceptible to errors. Therefore, there has been an increasing desire to find methods that can improve the assessment. OBJECTIVE:To describe...
journal_title：Brazilian journal of otorhinolaryngology
pub_type： 杂志文章
doi：10.1016/j.bjorl.2015.05.017
更新日期：2016-05-01 00:00:00
abstract：UNLABELLED:Cochlear implants are the best treatment for congenital profound deafness. Pediatric candidates to implantation are seen as vulnerable citizens, and the decision of implanting cochlear devices is ultimately in the hands of their parents/guardians. The Brazilian Penal Code dictates that deaf people may enjoy ...
journal_title：Brazilian journal of otorhinolaryngology
pub_type： 杂志文章
doi：
更新日期：2012-06-01 00:00:00
abstract：UNLABELLED:There are two techniques for cochlear implant (CI) electrode placement: cochleostomy and the round window (RW) approach. OBJECTIVE:This study aims to compare neural response telemetry (NRT) results immediately after surgery to check for possible differences on auditory nerve stimulation between these two te...
journal_title：Brazilian journal of otorhinolaryngology
pub_type： 杂志文章
doi：
更新日期：2012-07-01 00:00:00
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journal_title：Brazilian journal of otorhinolaryngology
pub_type： 杂志文章
doi：10.1016/j.bjorl.2014.03.001
更新日期：2014-11-01 00:00:00
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journal_title：Brazilian journal of otorhinolaryngology
pub_type： 杂志文章
doi：10.1016/s1808-8694(15)30119-1
更新日期：2007-09-01 00:00:00
abstract：INTRODUCTION:Congenital toxoplasmosis is an infectious disease with high prevalence in tropical countries. It is characterized by neurological, ophthalmological and auditory sequelae. OBJECTIVE:The aim of this study was to evaluate and describe the brainstem auditory evoked potential in infants aged 1-3 months diagnos...
journal_title：Brazilian journal of otorhinolaryngology
pub_type： 杂志文章
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journal_title：Brazilian journal of otorhinolaryngology
pub_type： 杂志文章,评审
doi：10.1016/j.bjorl.2014.07.011
更新日期：2014-09-01 00:00:00
abstract：UNLABELLED:Benign Positional Paroxysmal Vertigo (BPPV) is one of the most common vestibular diseases and the active head rotation test one of the most modern methods of vestibular function assessment. AIM:this study aims to verify if the active head rotation test may reveal signs of horizontal and/or vertical vestibul...
journal_title：Brazilian journal of otorhinolaryngology
pub_type： 杂志文章
doi：10.1016/s1808-8694(15)30500-0
更新日期：2009-07-01 00:00:00
abstract：INTRODUCTION:Several approaches have been tried for the treatment of tinnitus, from cognitive-behavioral therapies and sound enrichment to medication. In this context, antioxidants, widely used in numerous areas of medicine, appear to represent a promising approach for the control of this symptom, which often is poorly...
journal_title：Brazilian journal of otorhinolaryngology
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.bjorl.2015.04.016
更新日期：2016-05-01 00:00:00
abstract：UNLABELLED:Saccades are part of the electrooculography tests battery. The cerebellum has important connections with the brainstem and thalamic structures involved in the generation of saccades. AIM:to study saccadic movements in subjects with cerebellar disorders. STUDY METHOD:Prospective clinical study. MATERIALS A...
journal_title：Brazilian journal of otorhinolaryngology
pub_type： 杂志文章
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更新日期：2010-01-01 00:00:00
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journal_title：Brazilian journal of otorhinolaryngology
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.bjorl.2015.03.015
更新日期：2016-03-01 00:00:00
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journal_title：Brazilian journal of otorhinolaryngology
pub_type： 杂志文章
doi：10.1016/s1808-8694(15)31209-x
更新日期：2005-07-01 00:00:00
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journal_title：Brazilian journal of otorhinolaryngology
pub_type： 杂志文章
doi：10.5935/1808-8694.20130029
更新日期：2013-03-01 00:00:00
abstract：UNLABELLED:Myringosclerosis is characterized by hyaline changes of the lamina propria of the tympanic membrane. Experimental studies have used otomicroscopy or histology to evaluate myringosclerosis in animals, but they do not correlate precisely these two methods. AIM:The present study evaluates the accuracy of otomi...
journal_title：Brazilian journal of otorhinolaryngology
pub_type： 杂志文章
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更新日期：2005-09-01 00:00:00
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journal_title：Brazilian journal of otorhinolaryngology
pub_type： 杂志文章
doi：10.1016/j.bjorl.2017.05.002
更新日期：2018-01-01 00:00:00
abstract：INTRODUCTION:Newborn hearing screening (NHS) programs are implemented across the globe to detect early hearing impairment. In order to meet this objective, the quality of these programs should be monitored using internationally recognized indicators. OBJECTIVE:To evaluate a newborn hearing screening service (NHSS) usi...
journal_title：Brazilian journal of otorhinolaryngology
pub_type： 杂志文章
doi：10.1016/j.bjorl.2014.08.008
更新日期：2015-05-01 00:00:00
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journal_title：Brazilian journal of otorhinolaryngology
pub_type： 杂志文章
doi：10.1016/j.bjorl.2014.02.005
更新日期：2014-05-01 00:00:00
abstract：UNLABELLED:Balance disorders affect social, family and professional activities. Vestibular rehabilitation can reduce the impact of these disorders on the quality of life of individuals with vertigo. AIM:to study the influence of vestibular rehabilitation on the quality of life of individuals, correlating it with gende...
journal_title：Brazilian journal of otorhinolaryngology
pub_type： 杂志文章
doi：
更新日期：2009-05-01 00:00:00
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journal_title：Brazilian journal of otorhinolaryngology
pub_type： 杂志文章
doi：10.1016/S1808-8694(15)31378-1
更新日期：2008-09-01 00:00:00
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journal_title：Brazilian journal of otorhinolaryngology
pub_type： 杂志文章
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更新日期：2007-05-01 00:00:00
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journal_title：Brazilian journal of otorhinolaryngology
pub_type： 杂志文章
doi：10.1590/s1808-86942011000500013
更新日期：2011-09-01 00:00:00
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journal_title：Brazilian journal of otorhinolaryngology
pub_type： 杂志文章
doi：10.1016/j.bjorl.2019.08.002
更新日期：2019-09-14 00:00:00
abstract：INTRODUCTION:The diagnostic approach to patients with isolated asymptomatic cervical lymphadenopathy varies between excisional biopsy and follow-up. When the anamnesis, physical examination, laboratory and imaging findings are not sufficient to identify the etiology, an excisional biopsy is performed for the differenti...
journal_title：Brazilian journal of otorhinolaryngology
pub_type： 杂志文章
doi：10.1016/j.bjorl.2020.06.012
更新日期：2020-08-01 00:00:00
abstract：UNLABELLED:To setup an experimental model is the first step to study neural regeneration. AIM:Setting up an experimental model on facial nerve regeneration. MATERIAL AND METHODS:Wistar rats with complete sectioning and suturing of the extratemporal facial nerve trunk; with a behavioral and histological analysis for 9...
journal_title：Brazilian journal of otorhinolaryngology
pub_type： 杂志文章
doi：
更新日期：2006-11-01 00:00:00
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journal_title：Brazilian journal of otorhinolaryngology
pub_type： 杂志文章
doi：10.1016/j.bjorl.2014.07.001
更新日期：2014-09-01 00:00:00
abstract：:Created in 2007, COMUSA is a multiprofessional committee comprising speech therapy, otology, otorhinolaryngology and pediatrics with the aim of debating and countersigning auditory health actions for neonatal, lactating, preschool and school children, adolescents, adults and elderly persons. COMUSA includes representa...
journal_title：Brazilian journal of otorhinolaryngology
pub_type： 杂志文章
doi：
更新日期：2010-01-01 00:00:00
