Correlation between vascular endothelial growth factor expression and presence of lymph node metastasis in advanced squamous cell carcinoma of the larynx.

Abstract:

INTRODUCTION:Squamous cell carcinoma is the most common neoplasm of the larynx, and its evolution depends on tumor staging. Vascular endothelial growth factor is a marker of angiogenesis, and its expression may be related to increased tumor aggressiveness, as evidenced by the presence of cervical lymphatic metastases. OBJECTIVES:To evaluate the expression of the vascular endothelial growth factor marker in non-glottic advanced squamous cell carcinoma of the larynx (T3/T4) and correlate it with the presence of cervical lymph node metastases. METHODS:Retrospective clinical study and immunohistochemical analysis of vascular endothelial growth factor through the German scale of immunoreactivity in products of non-glottic squamous cell carcinomas. RESULTS:This study analyzed 15 cases of advanced non-glottic laryngeal tumors (T3/T4), four of which exhibited cervical lymphatic metastases. There was no correlation between vascular endothelial growth factor expression and the presence of cervical metastases. CONCLUSION:Although vascular endothelial growth factor was expressed in a few cases, there was no correlation with the spread of cervical lymph metastases.

authors

Bonhin RG,Rocha VB,Carvalho GM,Guimarães AC,Crespo AN,Chone CT,Amstalden EM

doi

10.1016/j.bjorl.2014.08.016

subject

Has Abstract

pub_date

2015-01-01 00:00:00

pages

58-62

issue

1

eissn

1808-8694

issn

1808-8686

pii

S1808-8694(14)00148-7

journal_volume

81

pub_type

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