Abstract:
UNLABELLED:Upper respiratory tract infections are the most common causes of medical visits in children and adults, demanding massive use of antibiotics. Bacterial resistance caused by beta-lactamase is one of the most serious problems in this matter. Sultamicillin, a double pro-drug of Ampicillin/Sulbactan, is a potent beta-lactamase inhibitor which can face this challenge. AIM:Evaluate efficacy, safety and tolerability of Ampicillin/Sulbactan compared to Amoxicillin/Clavulanate in upper respiratory tract infections in adults. METHODS:102 patients were enrolled and randomized to receive Ampicillin/Sulbactan or Amoxicillin/Clavulanate during 10 days. They were evaluated 10 and 30 days after treatment to learn about the therapeutic response. RESULTS:There were no differences between the two groups respecting cure at the end of treatment (visit 2) or at the end of the study (visit 3). Cure ratio was 61.7% and 93.2% (visits 2 and 3) in the Amoxicillin/Clavulanate group compared to 64.4% and 97.4%, respectively, in Ampicillin/Sulbactan group. The adverse events ratio for the two groups was the same (p=0.940). The number of patients with diarrhea was greater in the group of patients receiving Amoxicillin/Clavulanate (70.6%) than in the group receiving Ampicillin/Sulbactan (29.4%) (p=0.0164). CONCLUSIONS:Ampicillin/Sulbactan is as safe and efficient as Amoxicillin/Clavulanate in the empiric treatment of upper respiratory infections in adults. The low occurrence of diarrhea in the group receiving Ampicillin/Sulbactan needs confirmation in other studies.
journal_name
Braz J Otorhinolaryngoljournal_title
Brazilian journal of otorhinolaryngologyauthors
Ferreira JB,Rapoport PB,Sakano E,Kós AO,Piltcher OB,Pignatari SS,Pinheiro SD,Mocellin Mdoi
10.1016/s1808-8694(15)30041-0subject
Has Abstractpub_date
2006-01-01 00:00:00pages
104-11issue
1eissn
1808-8694issn
1808-8686pii
S1808-8694(15)30041-0journal_volume
72pub_type
杂志文章,多中心研究,随机对照试验abstract:UNLABELLED:Benign Positional Paroxysmal Vertigo (BPPV) is one of the most common vestibular diseases and the active head rotation test one of the most modern methods of vestibular function assessment. AIM:this study aims to verify if the active head rotation test may reveal signs of horizontal and/or vertical vestibul...
journal_title:Brazilian journal of otorhinolaryngology
pub_type: 杂志文章
doi:10.1016/s1808-8694(15)30500-0
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abstract:INTRODUCTION:The biological processes involved in noise-induced hearing loss (NIHL) are still unclear. The involvement of inflammation in this condition has been suggested. OBJECTIVE:To investigate the association between interleukin - 6 (IL-6) polymorphism and susceptibility to NIHL. METHODS:This was a cross-section...
journal_title:Brazilian journal of otorhinolaryngology
pub_type: 杂志文章
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abstract:UNLABELLED:Hearing impairment (HI) is characterized by unilateral hearing loss in one ear and can result in learning difficulties, language impairment and socio-emotional difficulties. To assess the perception of hearing handicap in adult subjects, patients with unilateral sensorineural HI, non-users of individual hear...
journal_title:Brazilian journal of otorhinolaryngology
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journal_title:Brazilian journal of otorhinolaryngology
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abstract:UNLABELLED:Cholesteatoma may occur either in children as in adults; in children, however, they have a more aggressive and extensive growth. OBJECTIVE:To compare the thickness of the perimatrix, in microm, between adults (>18 years old) and children cholesteatomas. STUDY DESIGN:transversal cohort. MATERIAL AND METHOD...
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pub_type: 杂志文章
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journal_title:Brazilian journal of otorhinolaryngology
pub_type: 杂志文章,评审
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journal_title:Brazilian journal of otorhinolaryngology
pub_type: 杂志文章
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pub_type: 杂志文章
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pub_type: 杂志文章
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journal_title:Brazilian journal of otorhinolaryngology
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journal_title:Brazilian journal of otorhinolaryngology
pub_type: 杂志文章
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journal_title:Brazilian journal of otorhinolaryngology
pub_type: 杂志文章
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pub_type: 杂志文章
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journal_title:Brazilian journal of otorhinolaryngology
pub_type: 杂志文章
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journal_title:Brazilian journal of otorhinolaryngology
pub_type: 杂志文章
doi:
更新日期:2010-03-01 00:00:00
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journal_title:Brazilian journal of otorhinolaryngology
pub_type: 杂志文章
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