Abstract：
UNLABELLED:The research involving tissue factors, such as granulocyte macrophage colonies stimulating factor (GM-CSF) and interleukin 5 (IL-5), leads to the mechanisms involved in the maintenance of eosinophilia, which is essential for the pathogenesis on eosinophilic nasal polyps. Mitomycin C has been successfully used in otolaryngology. AIM:The objective of this study was to evaluate the effect of mitomycin C in secretion of GM-CSF and IL-5 on eosinophilic nasal polyps. STUDY DESIGN:Case-control. MATERIAL AND METHOD:This is a comparative and auto-matched experimental study, performed with fragments of polyps which had been obtained from biopsy of patients with eosinophilic nasosinusal polyposis. The fragments of the experimental group were treated with mitomycin C (400 microg/ml) for 5 minutes and then washed in RPMI substrate. At time zero, 12 and 24 hours, the surface material was taken to determination of its GM-CSF levels in 22 patients and of IL-5 levels in 19 patients, by ELISA method. RESULTS:Reduction in GM-CSF expression on the experimental group at time 24 h (p< or = 0.05). The treated group presented significant GM-CSF expression between zero time and 12 h time (p= 0.013) showing the culture viability such as in the non-treated group. Tendency to decreasing IL-5 levels on the treated groups at 24 hours. CONCLUSION:This study showed that mitomycin C was efficient in inhibiting GM-CSF synthesis with reduction of IL-5 secretion, but this fact needs complementary studies.
journal_name
Braz J Otorhinolaryngoljournal_title
Brazilian journal of otorhinolaryngologyauthors
Crosara PF,Vasconcelos AC,Guimarães RE,Becker HM,Becker CG,Crosara SL,Nascimento Edoi
10.1016/s1808-8694(15)31199-xsubject
Has Abstractpub_date
2005-07-01 00:00:00pages
459-63issue
4eissn
1808-8694issn
1808-8686pii
S1808-8694(15)31199-Xjournal_volume
71pub_type
杂志文章abstract：UNLABELLED:Cochlear implant surgery is regarded as safe for the auditory rehabilitation of individuals suffering from profound/severe hearing loss. Complications may arise from the surgery. The complications of implant cochlear surgery reflect the operation complexity, the skill of the surgical team and the inherent ri...
journal_title：Brazilian journal of otorhinolaryngology
pub_type： 杂志文章
doi：
更新日期：2010-07-01 00:00:00
abstract：UNLABELLED:Long latency auditory evoked potentials (LLAEP) alterations in individuals with tinnitus are suggestive of dysfunction in the central auditory pathways at a cortical level. AIM:To characterize the LLAEP in individuals with and without tinnitus exposed to occupational noise. METHOD:Cross-sectional contempor...
journal_title：Brazilian journal of otorhinolaryngology
pub_type： 杂志文章
doi：
更新日期：2010-03-01 00:00:00
abstract：INTRODUCTION:Educators dealing with 0-6 years old children must be individuals who are willing to take all kind of measures in order to ensure the safety of children in educational institutions and playgrounds, providing protection from diseases, and who are able to apply first aid measures in case of an accident. OBJ...
journal_title：Brazilian journal of otorhinolaryngology
pub_type： 杂志文章
doi：10.1016/j.bjorl.2015.06.005
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abstract：UNLABELLED:The association between hearing and balance disorders with migraine is known since the times of the ancient Greeks, when Aretaeus from Cappadocia in 131 B.C, made an accurate and detailed description of this occurrence during a migraine episode. We present a broad review of migraine neurotological manifestat...
journal_title：Brazilian journal of otorhinolaryngology
pub_type： 杂志文章,评审
doi：10.1016/s1808-8694(15)30611-x
更新日期：2008-07-01 00:00:00
abstract：UNLABELLED:Individuals often seek help with foreign bodies (FB) in their ears, noses, and throats. Proper recognition, study, and management of foreign bodies is required to prevent complications. OBJECTIVE:To analyze the profile of the patients seen for FB at a reference otorhinolaryngology emergency care unit betwee...
journal_title：Brazilian journal of otorhinolaryngology
pub_type： 杂志文章
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abstract：INTRODUCTION:Supratracheal laryngectomy has been described as a surgical procedure for glottic or supraglottic cancer extending to the subglottic region and/or involving the cricoarytenoid joint, aiming to preserve laryngeal function (breathing, phonation and swallowing), without diminishing locoregional cancer control...
journal_title：Brazilian journal of otorhinolaryngology
pub_type： 杂志文章
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abstract：UNLABELLED:Obstructive sleep apnea syndrome (OSAS) is one of the most complex disorders of sleep; it involves several genetic factors that contribute to the phenotype. Serotonin (5-HT) regulates a variety of visceral and physiological functions, including sleep. Gene 5-HTR2A polymorphisms may change the transcription o...
journal_title：Brazilian journal of otorhinolaryngology
pub_type： 杂志文章
doi：10.1590/s1808-86942011000300013
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abstract：UNLABELLED:The hormonal changes that occur in a short time span promote modifications all over the woman's body, with physical and emotional manifestations which are frequently observed. AIM:to evaluate the activity of the external ciliated cells in women during their menstrual cycle, observing the effect of hormonal ...
journal_title：Brazilian journal of otorhinolaryngology
pub_type： 杂志文章
doi：10.1016/s1808-8694(15)30759-x
更新日期：2008-01-01 00:00:00
abstract：INTRODUCTION:Oropharyngeal dysphagia is a highly prevalent comorbidity in neurological patients and presents a serious health threat, which may lead to outcomes of aspiration pneumonia, ranging from hospitalization to death. This assessment proposes a non-invasive, acoustic-based method to differentiate between individ...
journal_title：Brazilian journal of otorhinolaryngology
pub_type： 杂志文章
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更新日期：2018-01-01 00:00:00
abstract：INTRODUCTION:Congenital toxoplasmosis is an infectious disease with high prevalence in tropical countries. It is characterized by neurological, ophthalmological and auditory sequelae. OBJECTIVE:The aim of this study was to evaluate and describe the brainstem auditory evoked potential in infants aged 1-3 months diagnos...
journal_title：Brazilian journal of otorhinolaryngology
pub_type： 杂志文章
doi：10.1016/j.bjorl.2018.03.012
更新日期：2019-01-01 00:00:00
abstract：:Dizziness is one of the most frequent complaints in both primary and specialized medical care facilities. Many dizzy patients, without a known organic cause, considered as having idiopathic dizziness, may have a psychiatric disorder. Besides, even organic dizziness may cause or exacerbate latent psychiatric alteration...
journal_title：Brazilian journal of otorhinolaryngology
pub_type： 杂志文章,评审
doi：10.1016/s1808-8694(15)30111-7
更新日期：2007-07-01 00:00:00
abstract：UNLABELLED:The auditory brainstem implant (ABI) is an option for deaf patients who do not have the whole of their auditory pathways preserved. The surgery, because of its anatomical and functional complexity, requires specific training of the surgeon in an anatomy lab. AIM:To study the surgical anatomy of the surgery ...
journal_title：Brazilian journal of otorhinolaryngology
pub_type： 杂志文章
doi：10.1016/s1808-8694(15)31324-0
更新日期：2005-05-01 00:00:00
abstract：UNLABELLED:Breathing is responsible for facial and cranial morphology development. AIM:investigate in order to see if there is any relationship between oral breathing and facial type. MATERIAL AND METHODS:119 male and female teenagers, with ages ranging between 15 and 18 years. The sample was separated in two groups:...
journal_title：Brazilian journal of otorhinolaryngology
pub_type： 杂志文章
doi：10.1016/s1808-8694(15)30101-4
更新日期：2007-07-01 00:00:00
abstract：:One in every 1,000 newborn suffers from congenital hearing impairment. More than 60% of the congenital cases are caused by genetic factors. In most cases, hearing loss is a multifactorial disorder caused by both genetic and environmental factors. Molecular genetics of deafness has experienced remarkable progress in th...
journal_title：Brazilian journal of otorhinolaryngology
pub_type： 杂志文章,评审
doi：10.1016/s1808-8694(15)31313-6
更新日期：2005-03-01 00:00:00
abstract：UNLABELLED:The possibility of needing a combined access, with neck and chest incisions makes the treatment of substernal goiter a challenge both in the pre-op and the intraoperative. We hereby, discuss a standardization of the surgical technique to minimize the need for a chest approach, making the substernal goiter a ...
journal_title：Brazilian journal of otorhinolaryngology
pub_type： 杂志文章
doi：10.1016/s1808-8694(15)30774-6
更新日期：2009-03-01 00:00:00
abstract：INTRODUCTION:Serum level of high-mobility group box 1 protein is reportedly correlated with the severity of obstructive sleep apnea. OBJECTIVE:We tried to evaluate the possibility of using the serum high-mobility group box 1 protein level as a biologic marker in obstructive sleep apnea patients. METHODS:We generated ...
journal_title：Brazilian journal of otorhinolaryngology
pub_type： 杂志文章
doi：10.1016/j.bjorl.2020.11.019
更新日期：2021-01-02 00:00:00
abstract：UNLABELLED:The Obstructive Sleep Apnea Syndrome is a chronic disease characterized by episodes upper airway collapse, and has been associated with increased cardiovascular morbidity. AIM:To correlate the neck, abdominal and pelvic circumference with the AHI and oxyhemoglobin saturation in OSA patients, and to correlat...
journal_title：Brazilian journal of otorhinolaryngology
pub_type： 杂志文章
doi：
更新日期：2011-07-01 00:00:00
abstract：UNLABELLED:Sjögren's Syndrome is an autoimmune disease of the exocrine glands, mainly salivary and lachrymal glands. There is no gold standard test for diagnosis. AIM:evaluation of the importance of minor salivary gland biopsy and sialometry, isolated or associated, as methods for classification of Sjögren's Syndrome....
journal_title：Brazilian journal of otorhinolaryngology
pub_type： 杂志文章
doi：/S0034-72992005000300014
更新日期：2005-05-01 00:00:00
abstract：INTRODUCTION:In many regions, laryngeal carcinoma is a common upper respiratory tract cancer, most commonly involving the glottic region. The treatment of early glottic cancer includes radiotherapy, open surgery and laryngeal laser microsurgery. However, the preferred treatment for early glottic cancer is still controv...
journal_title：Brazilian journal of otorhinolaryngology
pub_type： 杂志文章
doi：10.1016/j.bjorl.2020.06.013
更新日期：2020-08-06 00:00:00
abstract：INTRODUCTION:Tympanoplasty is performed to close the tympanic membrane perforation and recover the hearing level of patients with non-suppurative chronic otitis media. Endoscopic tympanoplasty has recently been increasingly preferred by ear nose and throat surgeons to treat tympanic membrane perforations. OBJECTIVE:Th...
journal_title：Brazilian journal of otorhinolaryngology
pub_type： 杂志文章
doi：10.1016/j.bjorl.2018.12.012
更新日期：2020-01-01 00:00:00
abstract：INTRODUCTION:Abused children and adolescents are exposed to factors that can trigger vocal changes. OBJECTIVE:This study aimed to analyze the prevalence of vocal changes in abused children and adolescents, through auditory-perceptual analysis of voice and the study of the association between vocal changes, communicati...
journal_title：Brazilian journal of otorhinolaryngology
pub_type： 杂志文章
doi：10.1016/j.bjorl.2014.11.006
更新日期：2015-01-01 00:00:00
abstract：UNLABELLED:Hearing aid fitting involves numerous issues that must be investigated - from the device supply all the way to results achieved with it in order to improve its results in planning Auditory Health Care. AIMS:to verify difficulties related to device use, batteries and ear molds handling, the very characterist...
journal_title：Brazilian journal of otorhinolaryngology
pub_type： 杂志文章
doi：10.1016/S1808-8694(15)31170-8
更新日期：2007-11-01 00:00:00
abstract：INTRODUCTION:The Montgomery T-tube is a device used as a combined tracheal stent and tracheostomy tube to prevent post-operative tracheal stenosis. OBJECTIVES:The purpose of this retrospective study is to evaluate the outcome following Montgomery T-tube stenting performed in for neck and airway injury in patients with...
journal_title：Brazilian journal of otorhinolaryngology
pub_type： 杂志文章
doi：10.1016/j.bjorl.2020.06.009
更新日期：2020-07-27 00:00:00
abstract：INTRODUCTION:Adenotonsillectomy is an invasive surgical procedure, which may encourage the search for information by the lay population through online search engines. The quality of this information, however, requires an evaluation due to the wide diversity of the available content. OBJECTIVE:To evaluate the quality, ...
journal_title：Brazilian journal of otorhinolaryngology
pub_type： 杂志文章
doi：10.1016/j.bjorl.2019.06.012
更新日期：2019-07-27 00:00:00
abstract：INTRODUCTION:The real number of COVID-19 cases may be underestimated since several countries have difficulty offering laboratory tests for all the population. Therefore, finding a symptom with a high predictive value would help in diagnostic and isolation strategies. OBJECTIVE:To correlate the sudden loss of the sense...
journal_title：Brazilian journal of otorhinolaryngology
pub_type： 杂志文章
doi：10.1016/j.bjorl.2020.05.002
更新日期：2020-01-01 00:00:00
abstract：INTRODUCTION:Severe obstructive sleep apnea is associated with increased QT corrected interval dispersion and continuous positive airway pressure is thought to improve this arrhythmogenic marker. OBJECTIVE:The aim of the study was to determine the decrease of ratio of cardiovascular risk in patients with obstructive s...
journal_title：Brazilian journal of otorhinolaryngology
pub_type： 杂志文章
doi：10.1016/j.bjorl.2017.03.005
更新日期：2018-01-01 00:00:00
abstract：UNLABELLED:Children with enlarged tonsils and adenoids usually present breathing abnormalities such as snoring, mouth breathing and sleep apnea. It is known that upper airway obstruction and consequent mouth breathing may result in pulmonary diseases. AIM:The goal of this preliminary study was to evaluate the inspirat...
journal_title：Brazilian journal of otorhinolaryngology
pub_type： 杂志文章
doi：10.1016/s1808-8694(15)31263-5
更新日期：2005-09-01 00:00:00
abstract：:The treatment of tinnitus, which is defined as conscientious perception of a sound originated in the ears or nervous system, represents until the current days a great challenge. The use of Acupuncture (ACP) is based on the stimulation with needles of specific points on the human anatomy. A prospective, randomized and ...
journal_title：Brazilian journal of otorhinolaryngology
pub_type： 杂志文章,随机对照试验
doi：10.1016/s1808-8694(15)30053-7
更新日期：2006-03-01 00:00:00
abstract：INTRODUCTION:Tinnitus is a multifactorial condition and its prevalence has increased on the past decades. The worldwide progressive increase of the use of cell phones has exposed the peripheral auditory pathways to a higher dose of electromagnetic radiofrequency radiation (EMRFR). Some tinnitus patients report that the...
journal_title：Brazilian journal of otorhinolaryngology
pub_type： 杂志文章,评审
doi：10.1016/j.bjorl.2015.04.013
更新日期：2016-01-01 00:00:00
abstract：UNLABELLED:High-frequency audiometry can detect early changes in auditory sensitivity resulting from processes such as aging. Nonetheless its use is still limited, and additional studies are required to establish its use, particularly among older adults. AIM:To compare pure tone thresholds for frequencies from 250 Hz ...
journal_title：Brazilian journal of otorhinolaryngology
pub_type： 杂志文章
doi：10.1016/s1808-8694(15)31024-7
更新日期：2006-09-01 00:00:00
