Abstract：
:The fungal diseases represent an increasing global health burden and have transformed from a rare curiosity to the leading cause of human mortality. The present manuscript reports the antifungal potential of two novel compounds possessing a carbohydrate and an imidazole moiety. Antifungal susceptibility test determined the growth inhibition potential of the synthesized compounds against Aspergillus niger 9689 and it was observed that compounds D and E gave an antifungal inhibitory index of 66.66 and 56.67% respectively. Further, ultra-structure analysis of the treated fungal mycelia through scanning electron microscope (SEM) and confocal microscopy indicated significant membrane permeability and disintegration of fungal cell membrane, thus highlighting the probable role of the synthesized compounds as inhibitors of fungal lanosterol 14α-demethylase. In silico studies corroborated with the in-vitro results, as the synthesized compounds interacted with the critical amino acids present at the active site of the fungal enzyme (lanosterol 14α-demethylase).
journal_name
J Mycol Medjournal_title
Journal de mycologie medicaleauthors
Deswal D,Shukla P,Azad CS,Narula AKdoi
10.1016/j.mycmed.2019.100910subject
Has Abstractpub_date
2020-04-01 00:00:00pages
100910issue
1eissn
1156-5233issn
1773-0449pii
S1156-5233(19)30285-9journal_volume
30pub_type
杂志文章abstract：OBJECTIVES:The aim of the present study was to evaluate the anticandidal activity of biologically synthesized silver nanoparticles using the culture filtrate of Streptomyces sp.VITPK1. MATERIALS AND METHODS:Silver nanoparticles were synthesized using the culture filtrate of Streptomyces species isolated from brine spr...
journal_title：Journal de mycologie medicale
pub_type： 杂志文章
doi：10.1016/j.mycmed.2014.03.004
更新日期：2014-09-01 00:00:00
abstract：:Mycetomas are localized chronic inflammatory infectious diseases involving subcutaneous tissues, skin and bones. We report a case of mycetoma in a 40-year-old farmer from the north of Senegal. The clinical appearance of the lesions suggested primarily the diagnosis of a soft tissue malignant tumor. Mycetoma diagnosis ...
journal_title：Journal de mycologie medicale
pub_type： 杂志文章
doi：10.1016/j.mycmed.2013.10.002
更新日期：2014-03-01 00:00:00
abstract：OBJECTIVE:The aim of this study was to investigate the antibiofilm activity of coumarin against Candida albicans. METHODS:The efficacy of coumarin against biofilm formation and the mature biofilm of C. albicans was quantified by crystal violet (CV) staining and the 2,3-bis (2-methoxy-4-nitro-5-sulfophenyl)-5-[(phenyla...
journal_title：Journal de mycologie medicale
pub_type： 杂志文章
doi：10.1016/j.mycmed.2018.12.003
更新日期：2019-04-01 00:00:00
abstract：INTRODUCTION:Iron chelator has previously demonstrated fungicidal effects. This study aimed to investigate the antifungal activity of the iron chelators deferoxamine (DFO) and deferasirox (DSX) against Cryptococcus. MATERIALS AND METHODS:Cryptococcus neoformans and Cryptococcus gattii were used to determine the minima...
journal_title：Journal de mycologie medicale
pub_type： 杂志文章
doi：10.1016/j.mycmed.2019.100905
更新日期：2020-04-01 00:00:00
abstract：OBJECTIVE:The aim of this study was the detection of Aspergillus species and Mycobacterium tuberculosis together in bronchoalveolar lavage (BAL) using of multiplex PCR. MATERIAL AND METHODS:In this study, from September 2012 until June 2013, 100 bronchoalveolar lavage (BAL) specimens were collected from patients suspe...
journal_title：Journal de mycologie medicale
pub_type： 杂志文章
doi：10.1016/j.mycmed.2015.02.041
更新日期：2015-06-01 00:00:00
abstract：INTRODUCTION:Airborne fungi are considered important causes of respiratory allergy and diseases. The knowledge of these fungi in a city or region is important for the ecological diagnosis and specific treatment of respiratory manifestations induced by inhalation of fungal agents. Therefore, in recent years bioaerosols ...
journal_title：Journal de mycologie medicale
pub_type： 杂志文章
doi：10.1016/j.mycmed.2017.12.002
更新日期：2018-03-01 00:00:00
abstract：:Yeasts can adhere to medical implants and cause infections responsible for high morbidity and mortality among hospitalized patients. The objective of this study is to investigate the infectivity on peripheral vascular catheters collected from general surgery and cardiology in University Hospital of Tlemcen. The result...
journal_title：Journal de mycologie medicale
pub_type： 杂志文章,评审
doi：10.1016/j.mycmed.2017.10.002
更新日期：2017-12-01 00:00:00
abstract：:This study evaluated the in vitro and in vivo activity of micafungin alone and in combination with the iron chelator deferasirox against Pythium insidiosum. Micafungin showed a poor in vitro activity when it was used alone, but synergistic interactions were observed for 88.2% of the strains when the drug was combined ...
journal_title：Journal de mycologie medicale
pub_type： 杂志文章
doi：10.1016/j.mycmed.2014.09.002
更新日期：2015-03-01 00:00:00
abstract：:The molecular mechanisms supporting resistance to azole antifungals have attracted a great interest during the last decades because of the emergence of clinical resistance to the treatment of fungal infections. The availability of genome sequencing data, of molecular biology tools, and of a large set of clinical and l...
journal_title：Journal de mycologie medicale
pub_type： 杂志文章,评审
doi：10.1016/j.mycmed.2012.04.004
更新日期：2012-06-01 00:00:00
abstract：OBJECTIVE:In this study, we demonstrate that vitamin D3 had fungicidal activity against Candida albicans. MATERIAL AND METHODS:The susceptibility of the yeast strain to the vitamin D3 was investigated by the antimicrobial screening using modified agar diffusion method, minimum fungistatic concentrations (MFCs) and min...
journal_title：Journal de mycologie medicale
pub_type： 杂志文章
doi：10.1016/j.mycmed.2016.10.003
更新日期：2017-03-01 00:00:00
abstract：OBJECTIVE:Dermatophytes are resistant to some available antibiotics. Development of new plant drugs to control drug resistant microbes is urgently needed. This study evaluates the antidermatophytic potential of 18 selected medicinal plants used by traditional healers in Theni and Virudhunagar Districts of Tamil Nadu, I...
journal_title：Journal de mycologie medicale
pub_type： 杂志文章
doi：10.1016/j.mycmed.2017.11.001
更新日期：2018-03-01 00:00:00
abstract：:The authors report a case of multifocal African histoplasmosis with polymorphic skin involvement occuring in a patient without proven immunosuppression. He was a young 22-year-old patient from eastern Senegal - but born in Ouganda - who presented with polymorphic skin lesions: ombilicated papulo-nodules, gums and ulce...
journal_title：Journal de mycologie medicale
pub_type： 杂志文章
doi：10.1016/j.mycmed.2016.03.004
更新日期：2016-09-01 00:00:00
abstract：:To study invasive pulmonary Aspergillosis (IPA), we depleted neutrophils in mice using the monoclonal antibody anti-Gr-1/Ly-6G. Immunocompetent and neutropenic mice were infected via intratracheal with conidia of Aspergillus fumigatus clinical isolates, characterized as either higher or lower elastase producers. Neutr...
journal_title：Journal de mycologie medicale
pub_type： 杂志文章
doi：10.1016/j.mycmed.2018.10.003
更新日期：2019-06-01 00:00:00
abstract：:We present the case of an actinomycotic mycetoma of the foot due to Actinomycetes viscosus. It evolved for nine years on the foot of a 26-year-old patient from a rural environment: Douar Inezgane (city in southern Morocco). Bacteriological study of the skin and grains confirmed the diagnosis. It showed positive bacill...
journal_title：Journal de mycologie medicale
pub_type： 杂志文章
doi：10.1016/j.mycmed.2014.10.025
更新日期：2015-03-01 00:00:00
abstract：:Candida spp. vertebral osteomyelitis is rare. Clinical presentation is unspecific. Diagnosis requires mycological culture of a biopsy specimen. Therapeutic management is based on prolonged course of azole or liposomal amphotericin B. We report the case of Candida tropicalis vertebral osteomyelitis with epidural involv...
journal_title：Journal de mycologie medicale
pub_type： 杂志文章
doi：10.1016/j.mycmed.2017.09.005
更新日期：2017-12-01 00:00:00
abstract：:Malassezia pachydermatis is an important opportunistic agent of dermatitis and otitis in dogs. M. pachydermatis is generally treated with topical therapies using combinations of antifungal, antimicrobial and anti-inflammatory agents. We investigated the in vitro activities of carvacrol (CRV), cinnamaldehyde (CIN) and ...
journal_title：Journal de mycologie medicale
pub_type： 杂志文章
doi：10.1016/j.mycmed.2019.08.003
更新日期：2019-12-01 00:00:00
abstract：:Curvularia lunata is a dematiaceous fungus that rarely causes cutaneous infections in immunocompetent humans. We describe a case of mycetoma pedis caused by Curvularia lunata in a 50-year-old woman from a rural farming community who had prolonged morbidity due to diagnostic delay. She improved with antifungal therapy,...
journal_title：Journal de mycologie medicale
pub_type： 杂志文章
doi：10.1016/j.mycmed.2013.09.005
更新日期：2014-06-01 00:00:00
abstract：:Dermatophytes are responsible for widespread superficial fungal infections, currently representing a real public health problem. Some of the fungi involved in these mycoses are transmitted by pets, illustrating great host specificity within this fungal group. Thus, a new variety of zoophilic dermatophyte has been desc...
journal_title：Journal de mycologie medicale
pub_type： 杂志文章
doi：10.1016/j.mycmed.2016.05.005
更新日期：2016-09-01 00:00:00
abstract：:One hundred and twenty-five samples were collected from eight different sites in the vicinity of Sanjay Gandhi National Park (SGNP) and screened for the presence of keratinophilic fungi using hair baiting technique for isolation. Seventy-three isolates were recovered and identified. The cultures were identified using ...
journal_title：Journal de mycologie medicale
pub_type： 杂志文章
doi：10.1016/j.mycmed.2014.08.004
更新日期：2014-12-01 00:00:00
abstract：:Histoplasmosis duboisii (Histoplasma capsulatum var duboisii) is uncommon disease especially in children. It is observed in Africa where the incidence is unknown. The authors report a series of three pediatric cases. The report concerned 2 girls and one boy who were 3, 9 and 4 year-old, respectively. Symptoms evolved ...
journal_title：Journal de mycologie medicale
pub_type： 杂志文章
doi：10.1016/j.mycmed.2017.01.013
更新日期：2017-06-01 00:00:00
abstract：:Saksenaea vasiformis is an emerging human pathogen, belonging to the order Mucorales of the subphylum Mucormycotina, most often associated with rhino-cerebral, cutaneous and subcutaneous infections following trauma. A review of the published literature was attempted on the occasion of a cutaneous leg infection with fa...
journal_title：Journal de mycologie medicale
pub_type： 杂志文章,评审
doi：10.1016/j.mycmed.2019.06.005
更新日期：2019-09-01 00:00:00
abstract：INTRODUCTION:Otomycosis, a superficial fungal infection of the external auditory canal (EAC), is a disease with exceptionally high prevalence. AIM:The aim of this study was to determine the prevalence of otomycosis, the distribution of causative species and to evaluate epidemiological characteristics of these infectio...
journal_title：Journal de mycologie medicale
pub_type： 杂志文章
doi：10.1016/j.mycmed.2020.101011
更新日期：2020-09-01 00:00:00
abstract：:Currently, marine organisms have a very important source of new molecules in pharmacology and thus in the development of new bioactive products. The organic and aqueous extracts of two marine sponges, Cinachyrella tarentine collected during two different seasons, winter and summer, and Cliona viridis collected in two ...
journal_title：Journal de mycologie medicale
pub_type： 杂志文章
doi：10.1016/j.mycmed.2010.11.005
更新日期：2011-03-01 00:00:00
abstract：THE AIM:The daily aeromycological monitoring of fungal spores in the city of Tetouan during the period 2009-2011, to determine their diversity, their predominance and their interannual and seasonal variation. MATERIAL AND METHODS:The spore sampling was undertaken using a Burkard volumetric spore trap. RESULTS:The out...
journal_title：Journal de mycologie medicale
pub_type： 杂志文章
doi：10.1016/j.mycmed.2016.02.018
更新日期：2016-06-01 00:00:00
abstract：UNLABELLED:Onychomycosis is the most common nail disease and its prevalence in the literature is estimated between 18 and 50%. The main objective of this study is to describe the epidemiology of onychomycosis and specify the most frequently fungal agents isolated at the University Hospital of Casablanca. MATERIAL AND ...
journal_title：Journal de mycologie medicale
pub_type： 杂志文章
doi：10.1016/j.mycmed.2012.10.002
更新日期：2013-03-01 00:00:00
abstract：INTRODUCTION:Comparing the activities of secreted enzymes in different fungal species can improve our understanding of their pathogenic role. Secretion of various enzymes by Candida species has been considered for determination of their virulence in different Candida infections including vulvovaginitis. AIMS:The aim o...
journal_title：Journal de mycologie medicale
pub_type： 杂志文章
doi：10.1016/j.mycmed.2017.01.009
更新日期：2017-06-01 00:00:00
abstract：:Tricyclazole as a common fungicide wildly used to control rice blast disease in the Asian country may induce azole resistance in Aspergillus fumigatus isolates. The main reason of the acquired azole resistance is probably environmental exposure through wide fungicide use in agriculture. The present study was conducted...
journal_title：Journal de mycologie medicale
pub_type： 杂志文章
doi：10.1016/j.mycmed.2017.12.007
更新日期：2018-03-01 00:00:00
abstract：:Cryptococcosis is a potentially fatal fungal disease caused by the basidiomycetes yeasts Cryptococcus neoformans and C. gattii with high predilection to invade the central nervous system mainly in immunocompromised hosts. Skin can be secondarily involved in disseminated infection or be exceptionally involved as primar...
journal_title：Journal de mycologie medicale
pub_type： 杂志文章
doi：10.1016/j.mycmed.2017.04.104
更新日期：2017-09-01 00:00:00
abstract：BACKGROUND:Rhizopus microsporus is one of the main causative agents of mucormycosis. These mycoses are mostly described as isolated cases involving uncontrolled diabetes mellitus or immunosuppressed patients. In this work we report a nosocomial outbreak of mucormycosis due to R. microsporum involving three young immuno...
journal_title：Journal de mycologie medicale
pub_type： 杂志文章
doi：10.1016/j.mycmed.2018.09.002
更新日期：2018-12-01 00:00:00
abstract：OBJECTIVE:To determine the fungal species isolated from skin lesions of different animals suspected of having dermatomycoses and their prevalence in different regions of Iran. MATERIALS AND METHODS:A total of 1011 animals (292 dogs, 229 cats, 168 horses, 100 camels, 98 cows, 60 squirrels, 37 birds, 15 sheep, 6 goats, ...
journal_title：Journal de mycologie medicale
pub_type： 杂志文章
doi：10.1016/j.mycmed.2016.04.007
更新日期：2016-06-01 00:00:00
