[African histoplamosis. A report of three pediatric cases].

Abstract:

:Histoplasmosis duboisii (Histoplasma capsulatum var duboisii) is uncommon disease especially in children. It is observed in Africa where the incidence is unknown. The authors report a series of three pediatric cases. The report concerned 2 girls and one boy who were 3, 9 and 4 year-old, respectively. Symptoms evolved for more than two months in each case. At admission, we found fever and poor general condition. Observed lesions were lymphnodes localisation disseminated (cases 1 and 2), subcutaneous (cold abscess) and cutaneous simulating molluscum contagiosum (case 2), osteoarticular (cases 2 and 3), abdominal including peritoneal and hepatosplenic (case 1). In all cases, a mild leukocytosis was found and an accelerated erythrocyte sedimentation rate (ESR) greater than 70mm. The HIV serology was negative. The treatment consisted of itraconazole in 2 cases and ketoconazole in one case. The evolution was insidious, leading to the discharge against medical advice. The death occurred at home in all cases. CONCLUSION:Histoplasmosis duboisii can realize two main clinical presentations (localized or disseminated), affecting the skin, lymph nodes, bones, sometimes the intra-abdominal organs. HIV serology is not always positive in disseminated forms. The evolution is unpredictable and capricious under antifungal treatment. The disease should be well explained to prevent a possible discharge against medical advice, often pejorative.

journal_name

J Mycol Med

authors

Mabiala Babela JR,Mboutol Mandavo C,Nika Evrard R,Ossibi Ibara B,Lamah L,Ollandzobo Ikobo LC,Mouko A,Peko JF

doi

10.1016/j.mycmed.2017.01.013

subject

Has Abstract

pub_date

2017-06-01 00:00:00

pages

133-138

issue

2

eissn

1156-5233

issn

1773-0449

pii

S1156-5233(16)30195-0

journal_volume

27

pub_type

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