Abstract：
OBJECTIVE:The aims of this study were to determine the role of live and heat-killed Aspergillus fumigatus conidia in releasing interleukin (IL)-25, IL-33 and thymic stromal lymphopoietin (TSLP) and to express Toll-like receptor (Tlr)2 and Tlr4 genes. MATERIALS AND METHODS:Murine lung epithelial cells were incubated with live and heat-killed A. fumigatus conidia at 37°C for 6, 24 and 48h. After treatments, ELISA was performed to measure the concentrations of IL-25, IL-33 and TSLP in the supernatants. Quantitative real-time PCR (qPCR) was performed to assess the expression levels of Tlr2 and Tlr4 genes. RESULTS:The concentrations of IL-25 and IL-33 significantly increased after exposure to live and heat-killed conidia for various times when compared with untreated control (P<0.05). The secretion of TSLP at different concentrations of heat-killed conidia was significantly higher than both live conidia and untreated control (P<0.05). qRT-PCR results indicated a up-regulation from 1.08 to 3.60-fold for Tlr2 gene expression and 1.20 to 1.80-fold for Tlr4 gene expression exposed to heat-killed conidia. CONCLUSION:A. fumigatus has a potential ability to stimulate murine lung epithelial cells to produce IL-25/IL-33/TSLP, as well as to express Tlr2/Tlr4 genes, indicating an important role of lung epithelial cells in innate immune responses to A. fumigatus interaction.
journal_name
J Mycol Medjournal_title
Journal de mycologie medicaleauthors
Khosravi AR,Shokri H,Hassan Al-Heidary S,Ghafarifar Fdoi
10.1016/j.mycmed.2018.02.001subject
Has Abstractpub_date
2018-06-01 00:00:00pages
349-354issue
2eissn
1156-5233issn
1773-0449pii
S1156-5233(17)30421-3journal_volume
28pub_type
杂志文章abstract：INTRODUCTION:Definition, diagnosis and treatment of allergic fungal sinusitis remain difficult and controversial despite the increasing number of publications. We report a case of an allergic fungal sinusitis with a review of the literature. CLINICAL CASE:A 45-year-old man consulted for sinusal polyposis resistant to ...
journal_title：Journal de mycologie medicale
pub_type： 杂志文章,评审
doi：10.1016/j.mycmed.2015.09.007
更新日期：2015-12-01 00:00:00
abstract：:Yeasts can adhere to medical implants and cause infections responsible for high morbidity and mortality among hospitalized patients. The objective of this study is to investigate the infectivity on peripheral vascular catheters collected from general surgery and cardiology in University Hospital of Tlemcen. The result...
journal_title：Journal de mycologie medicale
pub_type： 杂志文章,评审
doi：10.1016/j.mycmed.2017.10.002
更新日期：2017-12-01 00:00:00
abstract：OBJECTIVE:The increasing importance of dermatophytoses and emerging resistance of dermatophytes to current synthetic antifungals have stimulated the search for safer and more effective alternative drugs from natural sources. The present study was carried out to identify antagonistic bacteria of soil origin with strong ...
journal_title：Journal de mycologie medicale
pub_type： 杂志文章
doi：10.1016/j.mycmed.2014.01.117
更新日期：2014-06-01 00:00:00
abstract：UNLABELLED:Onychomycosis is the most common nail disease and its prevalence in the literature is estimated between 18 and 50%. The main objective of this study is to describe the epidemiology of onychomycosis and specify the most frequently fungal agents isolated at the University Hospital of Casablanca. MATERIAL AND ...
journal_title：Journal de mycologie medicale
pub_type： 杂志文章
doi：10.1016/j.mycmed.2012.10.002
更新日期：2013-03-01 00:00:00
abstract：:Mucormycosis is a progressive, opportunistic fungal infection with a high risk of mortality. Also mucormycosis may attack any organ system and may be accompanied by hemodynamic instability and difficult airway management. This study aimed to evaluate the anesthetic management of patients undergoing surgical resection ...
journal_title：Journal de mycologie medicale
pub_type： 杂志文章
doi：10.1016/j.mycmed.2019.07.001
更新日期：2019-09-01 00:00:00
abstract：:The molecular mechanisms supporting resistance to azole antifungals have attracted a great interest during the last decades because of the emergence of clinical resistance to the treatment of fungal infections. The availability of genome sequencing data, of molecular biology tools, and of a large set of clinical and l...
journal_title：Journal de mycologie medicale
pub_type： 杂志文章,评审
doi：10.1016/j.mycmed.2012.04.004
更新日期：2012-06-01 00:00:00
abstract：:Curvularia lunata is a dematiaceous fungus that rarely causes cutaneous infections in immunocompetent humans. We describe a case of mycetoma pedis caused by Curvularia lunata in a 50-year-old woman from a rural farming community who had prolonged morbidity due to diagnostic delay. She improved with antifungal therapy,...
journal_title：Journal de mycologie medicale
pub_type： 杂志文章
doi：10.1016/j.mycmed.2013.09.005
更新日期：2014-06-01 00:00:00
abstract：:Fusarium onychomycosis is not uncommon in tropical countries but is worth reporting. We report a case of nondermatophytic onychomycosis by Fusarium oxysporum in an immunocompetent woman from Buldhana district of Maharashtra (India). Bilateral involvement of great toe nail, chronic duration and acquisition of infection...
journal_title：Journal de mycologie medicale
pub_type： 杂志文章
doi：10.1016/j.mycmed.2015.12.003
更新日期：2016-03-01 00:00:00
abstract：INTRODUCTION:Iron chelator has previously demonstrated fungicidal effects. This study aimed to investigate the antifungal activity of the iron chelators deferoxamine (DFO) and deferasirox (DSX) against Cryptococcus. MATERIALS AND METHODS:Cryptococcus neoformans and Cryptococcus gattii were used to determine the minima...
journal_title：Journal de mycologie medicale
pub_type： 杂志文章
doi：10.1016/j.mycmed.2019.100905
更新日期：2020-04-01 00:00:00
abstract：OBJECTIVE:Candida parapsilosis species complex, an important set of non-albicans Candida species, is known to cause candidaemia particularly in neonates and infants. However, the incidence has increased in recent years, owing to higher numbers of at individuals at risk for these infections. Our objective was to evaluat...
journal_title：Journal de mycologie medicale
pub_type： 杂志文章
doi：10.1016/j.mycmed.2020.100968
更新日期：2020-09-01 00:00:00
abstract：:Human and animal mycoses become more frequent and more resistant to traditional treatments. In this work, we tested the in vitro antifungal activity of acetonic extracts of Punica granatum L., Quercus suber L. and Vicia faba L. against seven pathogen fungi and the in vivo antifungal activity against Candida albicans a...
journal_title：Journal de mycologie medicale
pub_type： 杂志文章
doi：10.1016/j.mycmed.2016.10.004
更新日期：2017-03-01 00:00:00
abstract：BACKGROUND:Rhizopus microsporus is one of the main causative agents of mucormycosis. These mycoses are mostly described as isolated cases involving uncontrolled diabetes mellitus or immunosuppressed patients. In this work we report a nosocomial outbreak of mucormycosis due to R. microsporum involving three young immuno...
journal_title：Journal de mycologie medicale
pub_type： 杂志文章
doi：10.1016/j.mycmed.2018.09.002
更新日期：2018-12-01 00:00:00
abstract：OBJECTIVES:The aim of the present study was to evaluate the anticandidal activity of biologically synthesized silver nanoparticles using the culture filtrate of Streptomyces sp.VITPK1. MATERIALS AND METHODS:Silver nanoparticles were synthesized using the culture filtrate of Streptomyces species isolated from brine spr...
journal_title：Journal de mycologie medicale
pub_type： 杂志文章
doi：10.1016/j.mycmed.2014.03.004
更新日期：2014-09-01 00:00:00
abstract：INTRODUCTION:Candida albicans is the most prevalent fungal pathogen in humans. Due to the development of drug resistance, there is today a need for new antifungal agents for the efficient management of C. albicans infections. Therefore, we reviewed antifungal activity, mechanisms of action, possible synergism with anti...
journal_title：Journal de mycologie medicale
pub_type： 杂志文章,评审
doi：10.1016/j.mycmed.2016.10.002
更新日期：2017-03-01 00:00:00
abstract：OBJECTIVE:In this paper, we describe the preparation and synthesis of several enynediesters, conjugated diynes and acetylenic compounds from starting materials comprising one hydroxyl and one acetylenyl group and their antifungal activity. MATERIALS AND METHODS:For synthesis of the compounds, a combined solution of N,...
journal_title：Journal de mycologie medicale
pub_type： 杂志文章
doi：10.1016/j.mycmed.2012.06.001
更新日期：2012-09-01 00:00:00
abstract：:Saksenaea vasiformis is an emerging human pathogen, belonging to the order Mucorales of the subphylum Mucormycotina, most often associated with rhino-cerebral, cutaneous and subcutaneous infections following trauma. A review of the published literature was attempted on the occasion of a cutaneous leg infection with fa...
journal_title：Journal de mycologie medicale
pub_type： 杂志文章,评审
doi：10.1016/j.mycmed.2019.06.005
更新日期：2019-09-01 00:00:00
abstract：BACKGROUND AND OBJECTIVE:Vulvovaginal candidiasis (VVC) is the most prevalent vaginitis in women, accounting for 10 million medical referrals a year. Vaginal clotrimazole is a drug of choice for VVC treatment. However, increased drug resistance to this microorganism has led to an interest in naturally derived antifunga...
journal_title：Journal de mycologie medicale
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.mycmed.2017.07.003
更新日期：2017-12-01 00:00:00
abstract：:Cryptococcosis is a potentially fatal fungal disease caused by the basidiomycetes yeasts Cryptococcus neoformans and C. gattii with high predilection to invade the central nervous system mainly in immunocompromised hosts. Skin can be secondarily involved in disseminated infection or be exceptionally involved as primar...
journal_title：Journal de mycologie medicale
pub_type： 杂志文章
doi：10.1016/j.mycmed.2017.04.104
更新日期：2017-09-01 00:00:00
abstract：:Histoplasmosis duboisii (Histoplasma capsulatum var duboisii) is uncommon disease especially in children. It is observed in Africa where the incidence is unknown. The authors report a series of three pediatric cases. The report concerned 2 girls and one boy who were 3, 9 and 4 year-old, respectively. Symptoms evolved ...
journal_title：Journal de mycologie medicale
pub_type： 杂志文章
doi：10.1016/j.mycmed.2017.01.013
更新日期：2017-06-01 00:00:00
abstract：OBJECTIVE:This study aimed at providing original data on fungemia in the Centre Hospitalier de Mayotte in terms of prevalence, epidemiological characteristics of infected patients, yeast species distribution and profile of in vitro antifungals susceptibility. METHODS:A total of 223 positive blood cultures for yeasts w...
journal_title：Journal de mycologie medicale
pub_type： 杂志文章
doi：10.1016/j.mycmed.2020.101081
更新日期：2020-11-18 00:00:00
abstract：:Dermatophytes are responsible for widespread superficial fungal infections, currently representing a real public health problem. Some of the fungi involved in these mycoses are transmitted by pets, illustrating great host specificity within this fungal group. Thus, a new variety of zoophilic dermatophyte has been desc...
journal_title：Journal de mycologie medicale
pub_type： 杂志文章
doi：10.1016/j.mycmed.2016.05.005
更新日期：2016-09-01 00:00:00
abstract：:We present the case of an actinomycotic mycetoma of the foot due to Actinomycetes viscosus. It evolved for nine years on the foot of a 26-year-old patient from a rural environment: Douar Inezgane (city in southern Morocco). Bacteriological study of the skin and grains confirmed the diagnosis. It showed positive bacill...
journal_title：Journal de mycologie medicale
pub_type： 杂志文章
doi：10.1016/j.mycmed.2014.10.025
更新日期：2015-03-01 00:00:00
abstract：OBJECTIVE:The objective of this study was to produce the bioactive fermented product by the microbial fermentation of cabbage (Brassica oleracea) using a bacterial strain Pectobacterium atrosepticum which was assessed for its antimycotic efficacy against pathogenic isolates of Candida species. MATERIALS AND METHODS:An...
journal_title：Journal de mycologie medicale
pub_type： 杂志文章
doi：10.1016/j.mycmed.2011.11.004
更新日期：2012-03-01 00:00:00
abstract：OBJECTIVE:In this study, we demonstrate that vitamin D3 had fungicidal activity against Candida albicans. MATERIAL AND METHODS:The susceptibility of the yeast strain to the vitamin D3 was investigated by the antimicrobial screening using modified agar diffusion method, minimum fungistatic concentrations (MFCs) and min...
journal_title：Journal de mycologie medicale
pub_type： 杂志文章
doi：10.1016/j.mycmed.2016.10.003
更新日期：2017-03-01 00:00:00
abstract：:In the end of May 2012, a meeting of the group "sérodiagnostic fongique" of the "Société française de mycologie médicale" had concerned quality controls to use, in particular, in the follow-up of Elisa techniques. A preliminary investigation showed that the internal quality controls (CIQ), according to the terms defin...
journal_title：Journal de mycologie medicale
pub_type： 杂志文章
doi：10.1016/j.mycmed.2012.11.001
更新日期：2013-03-01 00:00:00
abstract：:The authors report a case of multifocal African histoplasmosis with polymorphic skin involvement occuring in a patient without proven immunosuppression. He was a young 22-year-old patient from eastern Senegal - but born in Ouganda - who presented with polymorphic skin lesions: ombilicated papulo-nodules, gums and ulce...
journal_title：Journal de mycologie medicale
pub_type： 杂志文章
doi：10.1016/j.mycmed.2016.03.004
更新日期：2016-09-01 00:00:00
abstract：:Candida spp. is a common cause of invasive fungal disease. The aim of this study was to examine the susceptibility of Candida spp. to fluconazole, itraconazole and voriconazole and explore the correlation between triazoles susceptibility. The antifungal susceptibility in the present study was measured by ATB Fungus 3 ...
journal_title：Journal de mycologie medicale
pub_type： 杂志文章
doi：10.1016/j.mycmed.2018.03.005
更新日期：2018-06-01 00:00:00
abstract：:Malassezia pachydermatis is an important opportunistic agent of dermatitis and otitis in dogs. M. pachydermatis is generally treated with topical therapies using combinations of antifungal, antimicrobial and anti-inflammatory agents. We investigated the in vitro activities of carvacrol (CRV), cinnamaldehyde (CIN) and ...
journal_title：Journal de mycologie medicale
pub_type： 杂志文章
doi：10.1016/j.mycmed.2019.08.003
更新日期：2019-12-01 00:00:00
abstract：:This study evaluated the in vitro and in vivo activity of micafungin alone and in combination with the iron chelator deferasirox against Pythium insidiosum. Micafungin showed a poor in vitro activity when it was used alone, but synergistic interactions were observed for 88.2% of the strains when the drug was combined ...
journal_title：Journal de mycologie medicale
pub_type： 杂志文章
doi：10.1016/j.mycmed.2014.09.002
更新日期：2015-03-01 00:00:00
abstract：:Mycetomas are localized chronic inflammatory infectious diseases involving subcutaneous tissues, skin and bones. We report a case of mycetoma in a 40-year-old farmer from the north of Senegal. The clinical appearance of the lesions suggested primarily the diagnosis of a soft tissue malignant tumor. Mycetoma diagnosis ...
journal_title：Journal de mycologie medicale
pub_type： 杂志文章
doi：10.1016/j.mycmed.2013.10.002
更新日期：2014-03-01 00:00:00
