Abstract:
:Human and animal mycoses become more frequent and more resistant to traditional treatments. In this work, we tested the in vitro antifungal activity of acetonic extracts of Punica granatum L., Quercus suber L. and Vicia faba L. against seven pathogen fungi and the in vivo antifungal activity against Candida albicans and Trichophyton mentagrophytes. The phytochemical screening was also carried out and showed that the extracts contained mainly proanthocyanidins. Other polyphenols were also present but in low quantity. The acetone extract of V. faba L. gave a good in vitro inhibition of yeasts and was the most active for treating candidiasis in mice. It decreased the percentage of mortality with only 20μg. But the in vivo antifungal activity of this extract on T. mentagrophytes was low. It only showed a small diminution of crusting and erythema after the administration of 100μg. On the contrary, the acetone extracts of P. granatum L. had a poor activity against yeasts and a better one against moulds. It gave the best in vivo antifungal activity against T. mentagrophytes by healing animals with 40μg. The extract of P. granatum L. gave also an interesting in vivo antifungal activity against T. mentagrophytes with an active dose of 80μg.
journal_name
J Mycol Medjournal_title
Journal de mycologie medicaleauthors
Akroum Sdoi
10.1016/j.mycmed.2016.10.004subject
Has Abstractpub_date
2017-03-01 00:00:00pages
83-89issue
1eissn
1156-5233issn
1773-0449pii
S1156-5233(16)30126-3journal_volume
27pub_type
杂志文章abstract:OBJECTIVE:The increasing importance of dermatophytoses and emerging resistance of dermatophytes to current synthetic antifungals have stimulated the search for safer and more effective alternative drugs from natural sources. The present study was carried out to identify antagonistic bacteria of soil origin with strong ...
journal_title:Journal de mycologie medicale
pub_type: 杂志文章
doi:10.1016/j.mycmed.2014.01.117
更新日期:2014-06-01 00:00:00
abstract::One hundred and twenty-five samples were collected from eight different sites in the vicinity of Sanjay Gandhi National Park (SGNP) and screened for the presence of keratinophilic fungi using hair baiting technique for isolation. Seventy-three isolates were recovered and identified. The cultures were identified using ...
journal_title:Journal de mycologie medicale
pub_type: 杂志文章
doi:10.1016/j.mycmed.2014.08.004
更新日期:2014-12-01 00:00:00
abstract:INTRODUCTION:Otomycosis, a superficial fungal infection of the external auditory canal (EAC), is a disease with exceptionally high prevalence. AIM:The aim of this study was to determine the prevalence of otomycosis, the distribution of causative species and to evaluate epidemiological characteristics of these infectio...
journal_title:Journal de mycologie medicale
pub_type: 杂志文章
doi:10.1016/j.mycmed.2020.101011
更新日期:2020-09-01 00:00:00
abstract::Malassezia pachydermatis is an important opportunistic agent of dermatitis and otitis in dogs. M. pachydermatis is generally treated with topical therapies using combinations of antifungal, antimicrobial and anti-inflammatory agents. We investigated the in vitro activities of carvacrol (CRV), cinnamaldehyde (CIN) and ...
journal_title:Journal de mycologie medicale
pub_type: 杂志文章
doi:10.1016/j.mycmed.2019.08.003
更新日期:2019-12-01 00:00:00
abstract:OBJECTIVE:In this study, we demonstrate that vitamin D3 had fungicidal activity against Candida albicans. MATERIAL AND METHODS:The susceptibility of the yeast strain to the vitamin D3 was investigated by the antimicrobial screening using modified agar diffusion method, minimum fungistatic concentrations (MFCs) and min...
journal_title:Journal de mycologie medicale
pub_type: 杂志文章
doi:10.1016/j.mycmed.2016.10.003
更新日期:2017-03-01 00:00:00
abstract::The molecular mechanisms supporting resistance to azole antifungals have attracted a great interest during the last decades because of the emergence of clinical resistance to the treatment of fungal infections. The availability of genome sequencing data, of molecular biology tools, and of a large set of clinical and l...
journal_title:Journal de mycologie medicale
pub_type: 杂志文章,评审
doi:10.1016/j.mycmed.2012.04.004
更新日期:2012-06-01 00:00:00
abstract:OBJECTIVE:The effect of candidemia on immunologic parameters in breast tumor bearing patients is not well studied. Here, we hypothesised that candidemia in the tumor background may change the outcome of immunologic parameters and tumor condition. METHOD:Mice were divided into four groups, including normal, tumor, Cand...
journal_title:Journal de mycologie medicale
pub_type: 杂志文章
doi:10.1016/j.mycmed.2018.10.006
更新日期:2019-04-01 00:00:00
abstract::The growing trends of emergence of antifungal-resistant Candida strains has recently been inspired the researchers to design new antifungal agents with novel mechanisms of action. Glabridin is an originally natural substrate with multiple biological activities which propose it as a novel anticancer, antimicrobial and ...
journal_title:Journal de mycologie medicale
pub_type: 杂志文章
doi:10.1016/j.mycmed.2017.05.002
更新日期:2017-09-01 00:00:00
abstract:OBJECTIVE:The aims of this study were to determine the role of live and heat-killed Aspergillus fumigatus conidia in releasing interleukin (IL)-25, IL-33 and thymic stromal lymphopoietin (TSLP) and to express Toll-like receptor (Tlr)2 and Tlr4 genes. MATERIALS AND METHODS:Murine lung epithelial cells were incubated wi...
journal_title:Journal de mycologie medicale
pub_type: 杂志文章
doi:10.1016/j.mycmed.2018.02.001
更新日期:2018-06-01 00:00:00
abstract::The research concerns algae of the genus Prototheca. They are found in the natural environment and they can cause a disease in animals and humans called protothecosis. The aim of the study was to evaluate the in vitro activity of the fruit and vegetable rinse agent SunSmile® Fruit & Vegetable Rinse (Sunrider Internati...
journal_title:Journal de mycologie medicale
pub_type: 杂志文章
doi:10.1016/j.mycmed.2018.03.008
更新日期:2018-06-01 00:00:00
abstract::Cryptococcosis is a potentially fatal fungal disease caused by the basidiomycetes yeasts Cryptococcus neoformans and C. gattii with high predilection to invade the central nervous system mainly in immunocompromised hosts. Skin can be secondarily involved in disseminated infection or be exceptionally involved as primar...
journal_title:Journal de mycologie medicale
pub_type: 杂志文章
doi:10.1016/j.mycmed.2017.04.104
更新日期:2017-09-01 00:00:00
abstract:INTRODUCTION:Candida albicans is the most prevalent fungal pathogen in humans. Due to the development of drug resistance, there is today a need for new antifungal agents for the efficient management of C. albicans infections. Therefore, we reviewed antifungal activity, mechanisms of action, possible synergism with anti...
journal_title:Journal de mycologie medicale
pub_type: 杂志文章,评审
doi:10.1016/j.mycmed.2016.10.002
更新日期:2017-03-01 00:00:00
abstract::Emericella nidulans is a species that has only rarely been implicated in human disease after cataract surgery. Here, we report the first postoperative case in the literature, as far as we know. The patient was a 50-year-old patient presented with mild anterior uveitis one week after cataract surgery, and hypopion deve...
journal_title:Journal de mycologie medicale
pub_type: 杂志文章
doi:10.1016/j.mycmed.2015.12.010
更新日期:2016-09-01 00:00:00
abstract::Candida spp. is a common cause of invasive fungal disease. The aim of this study was to examine the susceptibility of Candida spp. to fluconazole, itraconazole and voriconazole and explore the correlation between triazoles susceptibility. The antifungal susceptibility in the present study was measured by ATB Fungus 3 ...
journal_title:Journal de mycologie medicale
pub_type: 杂志文章
doi:10.1016/j.mycmed.2018.03.005
更新日期:2018-06-01 00:00:00
abstract:OBJECTIVE:To check the oral colonization in neonates at high-risk and to associate these cases with candidemia. SUBJECTS AND METHODS:This study was conducted in the NICU. For six months, 125 high-risk neonates were investigated for oral colonization and septicemia by yeasts. From this total, 19 neonates had yeasts on ...
journal_title:Journal de mycologie medicale
pub_type: 杂志文章
doi:10.1016/j.mycmed.2013.11.004
更新日期:2014-06-01 00:00:00
abstract:BACKGROUND:Rhizopus microsporus is one of the main causative agents of mucormycosis. These mycoses are mostly described as isolated cases involving uncontrolled diabetes mellitus or immunosuppressed patients. In this work we report a nosocomial outbreak of mucormycosis due to R. microsporum involving three young immuno...
journal_title:Journal de mycologie medicale
pub_type: 杂志文章
doi:10.1016/j.mycmed.2018.09.002
更新日期:2018-12-01 00:00:00
abstract::Fusarium onychomycosis is not uncommon in tropical countries but is worth reporting. We report a case of nondermatophytic onychomycosis by Fusarium oxysporum in an immunocompetent woman from Buldhana district of Maharashtra (India). Bilateral involvement of great toe nail, chronic duration and acquisition of infection...
journal_title:Journal de mycologie medicale
pub_type: 杂志文章
doi:10.1016/j.mycmed.2015.12.003
更新日期:2016-03-01 00:00:00
abstract::Currently, marine organisms have a very important source of new molecules in pharmacology and thus in the development of new bioactive products. The organic and aqueous extracts of two marine sponges, Cinachyrella tarentine collected during two different seasons, winter and summer, and Cliona viridis collected in two ...
journal_title:Journal de mycologie medicale
pub_type: 杂志文章
doi:10.1016/j.mycmed.2010.11.005
更新日期:2011-03-01 00:00:00
abstract::Three chalcones, 2'-hydroxy-4,4',6'-trimethoxychalcone, 2'-hydroxy-4,4',6'-tetramethoxychalcone, and 3,2'-dihydroxy-4,4',6'-trimethoxychalcone, were isolated from the leaves of Piper hispidum in a bioguided fractionation of crude extract. The antimicrobial activity of crude extract of P. hispidum leaves was determined...
journal_title:Journal de mycologie medicale
pub_type: 杂志文章
doi:10.1016/j.mycmed.2016.03.002
更新日期:2016-09-01 00:00:00
abstract::We present the case of an actinomycotic mycetoma of the foot due to Actinomycetes viscosus. It evolved for nine years on the foot of a 26-year-old patient from a rural environment: Douar Inezgane (city in southern Morocco). Bacteriological study of the skin and grains confirmed the diagnosis. It showed positive bacill...
journal_title:Journal de mycologie medicale
pub_type: 杂志文章
doi:10.1016/j.mycmed.2014.10.025
更新日期:2015-03-01 00:00:00
abstract:OBJECTIVE:In this paper, we describe the preparation and synthesis of several enynediesters, conjugated diynes and acetylenic compounds from starting materials comprising one hydroxyl and one acetylenyl group and their antifungal activity. MATERIALS AND METHODS:For synthesis of the compounds, a combined solution of N,...
journal_title:Journal de mycologie medicale
pub_type: 杂志文章
doi:10.1016/j.mycmed.2012.06.001
更新日期:2012-09-01 00:00:00
abstract:OBJECTIVE:The aim of this study was the detection of Aspergillus species and Mycobacterium tuberculosis together in bronchoalveolar lavage (BAL) using of multiplex PCR. MATERIAL AND METHODS:In this study, from September 2012 until June 2013, 100 bronchoalveolar lavage (BAL) specimens were collected from patients suspe...
journal_title:Journal de mycologie medicale
pub_type: 杂志文章
doi:10.1016/j.mycmed.2015.02.041
更新日期:2015-06-01 00:00:00
abstract:BACKGROUND:Candidemia is a nosocomial infection of increasing importance, associated with high morbidity and mortality. The aim of this study is to describe the species distribution, risk factors, management and outcomes of patients with candidemia. METHODS:We conducted a retrospective study at Centro Hospitalar Unive...
journal_title:Journal de mycologie medicale
pub_type: 杂志文章
doi:10.1016/j.mycmed.2019.08.002
更新日期:2019-12-01 00:00:00
abstract:UNLABELLED:Yeasts occur as part of the normal human microbiota. Nevertheless, some species are opportunistic, affecting immunocompromised patients such as those undergoing oncologic treatment. OBJECTIVE:To detect the presence of yeasts in patients suffering from head and neck cancer who are receiving radiation therapy...
journal_title:Journal de mycologie medicale
pub_type: 杂志文章
doi:10.1016/j.mycmed.2012.08.002
更新日期:2012-12-01 00:00:00
abstract::Mucormycosis is a progressive, opportunistic fungal infection with a high risk of mortality. Also mucormycosis may attack any organ system and may be accompanied by hemodynamic instability and difficult airway management. This study aimed to evaluate the anesthetic management of patients undergoing surgical resection ...
journal_title:Journal de mycologie medicale
pub_type: 杂志文章
doi:10.1016/j.mycmed.2019.07.001
更新日期:2019-09-01 00:00:00
abstract::Candida nivariensis is a cryptic fungal species classified within the Candida glabrata complex. It was described for the first time in 2005 by the means of DNA sequencing. We report a rare case of C. nivariensis deep-seated infection occurring in a 77-year-old man hospitalized for cysto-prostatectomy. Phenotypic testi...
journal_title:Journal de mycologie medicale
pub_type: 杂志文章,评审
doi:10.1016/j.mycmed.2020.101042
更新日期:2020-12-01 00:00:00
abstract:INTRODUCTION:Iron chelator has previously demonstrated fungicidal effects. This study aimed to investigate the antifungal activity of the iron chelators deferoxamine (DFO) and deferasirox (DSX) against Cryptococcus. MATERIALS AND METHODS:Cryptococcus neoformans and Cryptococcus gattii were used to determine the minima...
journal_title:Journal de mycologie medicale
pub_type: 杂志文章
doi:10.1016/j.mycmed.2019.100905
更新日期:2020-04-01 00:00:00
abstract:OBJECTIVE:This study aimed at providing original data on fungemia in the Centre Hospitalier de Mayotte in terms of prevalence, epidemiological characteristics of infected patients, yeast species distribution and profile of in vitro antifungals susceptibility. METHODS:A total of 223 positive blood cultures for yeasts w...
journal_title:Journal de mycologie medicale
pub_type: 杂志文章
doi:10.1016/j.mycmed.2020.101081
更新日期:2020-11-18 00:00:00
abstract:INTRODUCTION:Airborne fungi are considered important causes of respiratory allergy and diseases. The knowledge of these fungi in a city or region is important for the ecological diagnosis and specific treatment of respiratory manifestations induced by inhalation of fungal agents. Therefore, in recent years bioaerosols ...
journal_title:Journal de mycologie medicale
pub_type: 杂志文章
doi:10.1016/j.mycmed.2017.12.002
更新日期:2018-03-01 00:00:00
abstract::Tineabarbae is a rare form of dermatophytosis that affects hair follicles of the beard and moustache. Dermoscopy could prove useful to identify parasitism of hair of the beard, just as it has proven useful in the diagnosis of Tineacapitis. We present the first fully documented case series of T. barbae with clinical, d...
journal_title:Journal de mycologie medicale
pub_type:
doi:10.1016/j.mycmed.2020.101104
更新日期:2020-12-15 00:00:00