Abstract：
OBJECTIVE:This study aimed at providing original data on fungemia in the Centre Hospitalier de Mayotte in terms of prevalence, epidemiological characteristics of infected patients, yeast species distribution and profile of in vitro antifungals susceptibility. METHODS:A total of 223 positive blood cultures for yeasts were retrospectively reported during the period April 2010-April 2020. RESULTS:Ninety-five episodes were identified corresponding to an incidence rate of 3.7 cases/100,000 inhabitants. The average age of patients was 33.5 years, and 63.3% patients were hospitalized in intensive care unit. The main co-morbidities were surgery in the 30 days prior to fungemia (27.8%), neoplasia (22.8%), parenteral nutrition (17.7%), diabetes (16.5%) and immunosuppressive medications (31.6%). Candida spp accounted for the majority of isolates (92.4%) with a predominance of non-albicans species (55.8% vs 33.7%), including C. albicans (33.7%), C. tropicalis (30.5%) and C. parapsilosis (20%). The antifungal susceptibility profiles did not differ from expected results for each species and did not change significantly over time. DISCUSSION:Fungemia remain frequent hospital infections associated with high mortality in Mayotte. The vast majority of fungemia was due to Candida spp. Non-albicansCandida species reach half of the Candida isolates with a high percentage of C. tropicalis. Surprisingly, no case of candidemia due to C. glabrata were identified. The management of candidemia remains satisfactory and the treatment was adapted according to the international recommendations. However, the high susceptibility of Candida spp. isolates to fluconazole may invite to reconsider the use of this molecule as empirical and first-line treatment of candidemia in Mayotte.
journal_name
J Mycol Medjournal_title
Journal de mycologie medicaleauthors
Wankap R,Mogo C,Niang M,Diallo A,Balloy L,Baes L,Collet L,Benoit-Cattin T,Permal S,Guegan H,Gangneux JPdoi
10.1016/j.mycmed.2020.101081subject
Has Abstractpub_date
2020-11-18 00:00:00pages
101081issue
1eissn
1156-5233issn
1773-0449pii
S1156-5233(20)30222-5journal_volume
31pub_type
杂志文章abstract：BACKGROUND:Candidemia is a nosocomial infection of increasing importance, associated with high morbidity and mortality. The aim of this study is to describe the species distribution, risk factors, management and outcomes of patients with candidemia. METHODS:We conducted a retrospective study at Centro Hospitalar Unive...
journal_title：Journal de mycologie medicale
pub_type： 杂志文章
doi：10.1016/j.mycmed.2019.08.002
更新日期：2019-12-01 00:00:00
abstract：:One hundred and twenty-five samples were collected from eight different sites in the vicinity of Sanjay Gandhi National Park (SGNP) and screened for the presence of keratinophilic fungi using hair baiting technique for isolation. Seventy-three isolates were recovered and identified. The cultures were identified using ...
journal_title：Journal de mycologie medicale
pub_type： 杂志文章
doi：10.1016/j.mycmed.2014.08.004
更新日期：2014-12-01 00:00:00
abstract：INTRODUCTION:Iron chelator has previously demonstrated fungicidal effects. This study aimed to investigate the antifungal activity of the iron chelators deferoxamine (DFO) and deferasirox (DSX) against Cryptococcus. MATERIALS AND METHODS:Cryptococcus neoformans and Cryptococcus gattii were used to determine the minima...
journal_title：Journal de mycologie medicale
pub_type： 杂志文章
doi：10.1016/j.mycmed.2019.100905
更新日期：2020-04-01 00:00:00
abstract：:The fungal diseases represent an increasing global health burden and have transformed from a rare curiosity to the leading cause of human mortality. The present manuscript reports the antifungal potential of two novel compounds possessing a carbohydrate and an imidazole moiety. Antifungal susceptibility test determine...
journal_title：Journal de mycologie medicale
pub_type： 杂志文章
doi：10.1016/j.mycmed.2019.100910
更新日期：2020-04-01 00:00:00
abstract：:In the end of May 2012, a meeting of the group "sérodiagnostic fongique" of the "Société française de mycologie médicale" had concerned quality controls to use, in particular, in the follow-up of Elisa techniques. A preliminary investigation showed that the internal quality controls (CIQ), according to the terms defin...
journal_title：Journal de mycologie medicale
pub_type： 杂志文章
doi：10.1016/j.mycmed.2012.11.001
更新日期：2013-03-01 00:00:00
abstract：OBJECTIVE:Candida parapsilosis species complex, an important set of non-albicans Candida species, is known to cause candidaemia particularly in neonates and infants. However, the incidence has increased in recent years, owing to higher numbers of at individuals at risk for these infections. Our objective was to evaluat...
journal_title：Journal de mycologie medicale
pub_type： 杂志文章
doi：10.1016/j.mycmed.2020.100968
更新日期：2020-09-01 00:00:00
abstract：:Curvularia lunata is a dematiaceous fungus that rarely causes cutaneous infections in immunocompetent humans. We describe a case of mycetoma pedis caused by Curvularia lunata in a 50-year-old woman from a rural farming community who had prolonged morbidity due to diagnostic delay. She improved with antifungal therapy,...
journal_title：Journal de mycologie medicale
pub_type： 杂志文章
doi：10.1016/j.mycmed.2013.09.005
更新日期：2014-06-01 00:00:00
abstract：:This study evaluated the in vitro and in vivo activity of micafungin alone and in combination with the iron chelator deferasirox against Pythium insidiosum. Micafungin showed a poor in vitro activity when it was used alone, but synergistic interactions were observed for 88.2% of the strains when the drug was combined ...
journal_title：Journal de mycologie medicale
pub_type： 杂志文章
doi：10.1016/j.mycmed.2014.09.002
更新日期：2015-03-01 00:00:00
abstract：INTRODUCTION:Otomycosis, a superficial fungal infection of the external auditory canal (EAC), is a disease with exceptionally high prevalence. AIM:The aim of this study was to determine the prevalence of otomycosis, the distribution of causative species and to evaluate epidemiological characteristics of these infectio...
journal_title：Journal de mycologie medicale
pub_type： 杂志文章
doi：10.1016/j.mycmed.2020.101011
更新日期：2020-09-01 00:00:00
abstract：:Saksenaea vasiformis is an emerging human pathogen, belonging to the order Mucorales of the subphylum Mucormycotina, most often associated with rhino-cerebral, cutaneous and subcutaneous infections following trauma. A review of the published literature was attempted on the occasion of a cutaneous leg infection with fa...
journal_title：Journal de mycologie medicale
pub_type： 杂志文章,评审
doi：10.1016/j.mycmed.2019.06.005
更新日期：2019-09-01 00:00:00
abstract：OBJECTIVE:The aims of this study were to determine the role of live and heat-killed Aspergillus fumigatus conidia in releasing interleukin (IL)-25, IL-33 and thymic stromal lymphopoietin (TSLP) and to express Toll-like receptor (Tlr)2 and Tlr4 genes. MATERIALS AND METHODS:Murine lung epithelial cells were incubated wi...
journal_title：Journal de mycologie medicale
pub_type： 杂志文章
doi：10.1016/j.mycmed.2018.02.001
更新日期：2018-06-01 00:00:00
abstract：OBJECTIVE:Dermatophytes are resistant to some available antibiotics. Development of new plant drugs to control drug resistant microbes is urgently needed. This study evaluates the antidermatophytic potential of 18 selected medicinal plants used by traditional healers in Theni and Virudhunagar Districts of Tamil Nadu, I...
journal_title：Journal de mycologie medicale
pub_type： 杂志文章
doi：10.1016/j.mycmed.2017.11.001
更新日期：2018-03-01 00:00:00
abstract：:Candida spp. vertebral osteomyelitis is rare. Clinical presentation is unspecific. Diagnosis requires mycological culture of a biopsy specimen. Therapeutic management is based on prolonged course of azole or liposomal amphotericin B. We report the case of Candida tropicalis vertebral osteomyelitis with epidural involv...
journal_title：Journal de mycologie medicale
pub_type： 杂志文章
doi：10.1016/j.mycmed.2017.09.005
更新日期：2017-12-01 00:00:00
abstract：:To study invasive pulmonary Aspergillosis (IPA), we depleted neutrophils in mice using the monoclonal antibody anti-Gr-1/Ly-6G. Immunocompetent and neutropenic mice were infected via intratracheal with conidia of Aspergillus fumigatus clinical isolates, characterized as either higher or lower elastase producers. Neutr...
journal_title：Journal de mycologie medicale
pub_type： 杂志文章
doi：10.1016/j.mycmed.2018.10.003
更新日期：2019-06-01 00:00:00
abstract：OBJECTIVE:The aim of this study was to investigate the antibiofilm activity of coumarin against Candida albicans. METHODS:The efficacy of coumarin against biofilm formation and the mature biofilm of C. albicans was quantified by crystal violet (CV) staining and the 2,3-bis (2-methoxy-4-nitro-5-sulfophenyl)-5-[(phenyla...
journal_title：Journal de mycologie medicale
pub_type： 杂志文章
doi：10.1016/j.mycmed.2018.12.003
更新日期：2019-04-01 00:00:00
abstract：:The aim of this research is to verify the yeast species isolated from oral mucosa in street mixed-breed dogs and to determine the antifungal profiles. After capturing and sedating the animals, oral mucosa samples were collected from fifty dogs and the materials were inoculated on Sabouraud dextrose agar with chloramph...
journal_title：Journal de mycologie medicale
pub_type： 杂志文章
doi：10.1016/j.mycmed.2020.101010
更新日期：2020-12-01 00:00:00
abstract：OBJECTIVE:The increasing importance of dermatophytoses and emerging resistance of dermatophytes to current synthetic antifungals have stimulated the search for safer and more effective alternative drugs from natural sources. The present study was carried out to identify antagonistic bacteria of soil origin with strong ...
journal_title：Journal de mycologie medicale
pub_type： 杂志文章
doi：10.1016/j.mycmed.2014.01.117
更新日期：2014-06-01 00:00:00
abstract：:Tineabarbae is a rare form of dermatophytosis that affects hair follicles of the beard and moustache. Dermoscopy could prove useful to identify parasitism of hair of the beard, just as it has proven useful in the diagnosis of Tineacapitis. We present the first fully documented case series of T. barbae with clinical, d...
journal_title：Journal de mycologie medicale
pub_type：
doi：10.1016/j.mycmed.2020.101104
更新日期：2020-12-15 00:00:00
abstract：INTRODUCTION:Candida albicans is the most prevalent fungal pathogen in humans. Due to the development of drug resistance, there is today a need for new antifungal agents for the efficient management of C. albicans infections. Therefore, we reviewed antifungal activity, mechanisms of action, possible synergism with anti...
journal_title：Journal de mycologie medicale
pub_type： 杂志文章,评审
doi：10.1016/j.mycmed.2016.10.002
更新日期：2017-03-01 00:00:00
abstract：OBJECTIVE:This study was carried out to show possible similarities between discoid lupus erythematosus clinical signs and histopathological findings and dermatophytosis. PATIENT AND METHODS:A 43-year-old woman with diffused erythematous scaling lesions on her neck was studied. Skin biopsy was performed using H&E and P...
journal_title：Journal de mycologie medicale
pub_type： 杂志文章
doi：10.1016/j.mycmed.2011.12.001
更新日期：2012-03-01 00:00:00
abstract：:Tricyclazole as a common fungicide wildly used to control rice blast disease in the Asian country may induce azole resistance in Aspergillus fumigatus isolates. The main reason of the acquired azole resistance is probably environmental exposure through wide fungicide use in agriculture. The present study was conducted...
journal_title：Journal de mycologie medicale
pub_type： 杂志文章
doi：10.1016/j.mycmed.2017.12.007
更新日期：2018-03-01 00:00:00
abstract：:Currently, marine organisms have a very important source of new molecules in pharmacology and thus in the development of new bioactive products. The organic and aqueous extracts of two marine sponges, Cinachyrella tarentine collected during two different seasons, winter and summer, and Cliona viridis collected in two ...
journal_title：Journal de mycologie medicale
pub_type： 杂志文章
doi：10.1016/j.mycmed.2010.11.005
更新日期：2011-03-01 00:00:00
abstract：OBJECTIVE:In this study, we demonstrate that vitamin D3 had fungicidal activity against Candida albicans. MATERIAL AND METHODS:The susceptibility of the yeast strain to the vitamin D3 was investigated by the antimicrobial screening using modified agar diffusion method, minimum fungistatic concentrations (MFCs) and min...
journal_title：Journal de mycologie medicale
pub_type： 杂志文章
doi：10.1016/j.mycmed.2016.10.003
更新日期：2017-03-01 00:00:00
abstract：OBJECTIVE:To check the oral colonization in neonates at high-risk and to associate these cases with candidemia. SUBJECTS AND METHODS:This study was conducted in the NICU. For six months, 125 high-risk neonates were investigated for oral colonization and septicemia by yeasts. From this total, 19 neonates had yeasts on ...
journal_title：Journal de mycologie medicale
pub_type： 杂志文章
doi：10.1016/j.mycmed.2013.11.004
更新日期：2014-06-01 00:00:00
abstract：BACKGROUND:Rhizopus microsporus is one of the main causative agents of mucormycosis. These mycoses are mostly described as isolated cases involving uncontrolled diabetes mellitus or immunosuppressed patients. In this work we report a nosocomial outbreak of mucormycosis due to R. microsporum involving three young immuno...
journal_title：Journal de mycologie medicale
pub_type： 杂志文章
doi：10.1016/j.mycmed.2018.09.002
更新日期：2018-12-01 00:00:00
abstract：:The authors report a case of multifocal African histoplasmosis with polymorphic skin involvement occuring in a patient without proven immunosuppression. He was a young 22-year-old patient from eastern Senegal - but born in Ouganda - who presented with polymorphic skin lesions: ombilicated papulo-nodules, gums and ulce...
journal_title：Journal de mycologie medicale
pub_type： 杂志文章
doi：10.1016/j.mycmed.2016.03.004
更新日期：2016-09-01 00:00:00
abstract：:In Algeria, many bacterial biofilms have been studied but those of fungal origin, particularly those due to the yeast Candida albicans remained unidentified. The present study was performed at the Chabane Hamdoune hospital in Maghnia (Algeria), where 51 strains of C. albicans representing 16.94% of all taken samples w...
journal_title：Journal de mycologie medicale
pub_type： 杂志文章
doi：10.1016/j.mycmed.2011.07.006
更新日期：2011-09-01 00:00:00
abstract：:The molecular mechanisms supporting resistance to azole antifungals have attracted a great interest during the last decades because of the emergence of clinical resistance to the treatment of fungal infections. The availability of genome sequencing data, of molecular biology tools, and of a large set of clinical and l...
journal_title：Journal de mycologie medicale
pub_type： 杂志文章,评审
doi：10.1016/j.mycmed.2012.04.004
更新日期：2012-06-01 00:00:00
abstract：:The growing trends of emergence of antifungal-resistant Candida strains has recently been inspired the researchers to design new antifungal agents with novel mechanisms of action. Glabridin is an originally natural substrate with multiple biological activities which propose it as a novel anticancer, antimicrobial and ...
journal_title：Journal de mycologie medicale
pub_type： 杂志文章
doi：10.1016/j.mycmed.2017.05.002
更新日期：2017-09-01 00:00:00
abstract：:Emericella nidulans is a species that has only rarely been implicated in human disease after cataract surgery. Here, we report the first postoperative case in the literature, as far as we know. The patient was a 50-year-old patient presented with mild anterior uveitis one week after cataract surgery, and hypopion deve...
journal_title：Journal de mycologie medicale
pub_type： 杂志文章
doi：10.1016/j.mycmed.2015.12.010
更新日期：2016-09-01 00:00:00
