Abstract：
BACKGROUND:Candidemia is a nosocomial infection of increasing importance, associated with high morbidity and mortality. The aim of this study is to describe the species distribution, risk factors, management and outcomes of patients with candidemia. METHODS:We conducted a retrospective study at Centro Hospitalar Universitário de São João, Portugal, between January 2016 and December 2017. RESULTS:A total of 117 candidemia episodes (n=114 patients) were included. Median age was 65 years, with an increased prevalence of older ages. Candida albicans (51.3%) was the most prevalent species, followed by C. glabrata (22.2%), C. parapsilosis (15.4%), C. tropicalis (4.3%) and C. lusitaniae (2.6%). Forty-two patients (35.9%) did not receive antifungal drugs after diagnosis of candidemia. Echinocandins were used as first-line drug therapy in half of the treated patients (50.7%). The median EQUAL Candida Score was 6/17 (IQR 6-9) for patients without central venous catheter (CVC) and 11/20 (IQR 6-14) for patients with CVC. The 30 days-mortality was 31,6% and was not significantly associated with the timing of antifungal therapy and the EQUAL Candida Score. CONCLUSION:The distribution of Candida species has changed in recent years, with an increase in the proportion of C. albicans and C. glabrata. Rapid diagnostic tests, empiric antifungal therapy and source control are essential to improve the prognosis of patients with candidemia. More multicentric prospective studies are needed to evaluate the association of mortality with the timing of antifungal therapy or the EQUAL Candida Score.
journal_name
J Mycol Medjournal_title
Journal de mycologie medicaleauthors
Pinto-Magalhães S,Martins A,Lacerda S,Filipe R,Prista-Leão B,Pinheiro D,Silva-Pinto A,Santos Ldoi
10.1016/j.mycmed.2019.08.002subject
Has Abstractpub_date
2019-12-01 00:00:00pages
320-324issue
4eissn
1156-5233issn
1773-0449pii
S1156-5233(19)30115-5journal_volume
29pub_type
杂志文章abstract：OBJECTIVE:To check the oral colonization in neonates at high-risk and to associate these cases with candidemia. SUBJECTS AND METHODS:This study was conducted in the NICU. For six months, 125 high-risk neonates were investigated for oral colonization and septicemia by yeasts. From this total, 19 neonates had yeasts on ...
journal_title：Journal de mycologie medicale
pub_type： 杂志文章
doi：10.1016/j.mycmed.2013.11.004
更新日期：2014-06-01 00:00:00
abstract：:This study evaluated the in vitro and in vivo activity of micafungin alone and in combination with the iron chelator deferasirox against Pythium insidiosum. Micafungin showed a poor in vitro activity when it was used alone, but synergistic interactions were observed for 88.2% of the strains when the drug was combined ...
journal_title：Journal de mycologie medicale
pub_type： 杂志文章
doi：10.1016/j.mycmed.2014.09.002
更新日期：2015-03-01 00:00:00
abstract：:The authors report a case of multifocal African histoplasmosis with polymorphic skin involvement occuring in a patient without proven immunosuppression. He was a young 22-year-old patient from eastern Senegal - but born in Ouganda - who presented with polymorphic skin lesions: ombilicated papulo-nodules, gums and ulce...
journal_title：Journal de mycologie medicale
pub_type： 杂志文章
doi：10.1016/j.mycmed.2016.03.004
更新日期：2016-09-01 00:00:00
abstract：:Candida spp. vertebral osteomyelitis is rare. Clinical presentation is unspecific. Diagnosis requires mycological culture of a biopsy specimen. Therapeutic management is based on prolonged course of azole or liposomal amphotericin B. We report the case of Candida tropicalis vertebral osteomyelitis with epidural involv...
journal_title：Journal de mycologie medicale
pub_type： 杂志文章
doi：10.1016/j.mycmed.2017.09.005
更新日期：2017-12-01 00:00:00
abstract：:Tricyclazole as a common fungicide wildly used to control rice blast disease in the Asian country may induce azole resistance in Aspergillus fumigatus isolates. The main reason of the acquired azole resistance is probably environmental exposure through wide fungicide use in agriculture. The present study was conducted...
journal_title：Journal de mycologie medicale
pub_type： 杂志文章
doi：10.1016/j.mycmed.2017.12.007
更新日期：2018-03-01 00:00:00
abstract：:Histoplasmosis duboisii (Histoplasma capsulatum var duboisii) is uncommon disease especially in children. It is observed in Africa where the incidence is unknown. The authors report a series of three pediatric cases. The report concerned 2 girls and one boy who were 3, 9 and 4 year-old, respectively. Symptoms evolved ...
journal_title：Journal de mycologie medicale
pub_type： 杂志文章
doi：10.1016/j.mycmed.2017.01.013
更新日期：2017-06-01 00:00:00
abstract：:Three chalcones, 2'-hydroxy-4,4',6'-trimethoxychalcone, 2'-hydroxy-4,4',6'-tetramethoxychalcone, and 3,2'-dihydroxy-4,4',6'-trimethoxychalcone, were isolated from the leaves of Piper hispidum in a bioguided fractionation of crude extract. The antimicrobial activity of crude extract of P. hispidum leaves was determined...
journal_title：Journal de mycologie medicale
pub_type： 杂志文章
doi：10.1016/j.mycmed.2016.03.002
更新日期：2016-09-01 00:00:00
abstract：UNLABELLED:Onychomycosis is the most common nail disease and its prevalence in the literature is estimated between 18 and 50%. The main objective of this study is to describe the epidemiology of onychomycosis and specify the most frequently fungal agents isolated at the University Hospital of Casablanca. MATERIAL AND ...
journal_title：Journal de mycologie medicale
pub_type： 杂志文章
doi：10.1016/j.mycmed.2012.10.002
更新日期：2013-03-01 00:00:00
abstract：INTRODUCTION:Definition, diagnosis and treatment of allergic fungal sinusitis remain difficult and controversial despite the increasing number of publications. We report a case of an allergic fungal sinusitis with a review of the literature. CLINICAL CASE:A 45-year-old man consulted for sinusal polyposis resistant to ...
journal_title：Journal de mycologie medicale
pub_type： 杂志文章,评审
doi：10.1016/j.mycmed.2015.09.007
更新日期：2015-12-01 00:00:00
abstract：:The research concerns algae of the genus Prototheca. They are found in the natural environment and they can cause a disease in animals and humans called protothecosis. The aim of the study was to evaluate the in vitro activity of the fruit and vegetable rinse agent SunSmile® Fruit & Vegetable Rinse (Sunrider Internati...
journal_title：Journal de mycologie medicale
pub_type： 杂志文章
doi：10.1016/j.mycmed.2018.03.008
更新日期：2018-06-01 00:00:00
abstract：OBJECTIVE:In this paper, we describe the preparation and synthesis of several enynediesters, conjugated diynes and acetylenic compounds from starting materials comprising one hydroxyl and one acetylenyl group and their antifungal activity. MATERIALS AND METHODS:For synthesis of the compounds, a combined solution of N,...
journal_title：Journal de mycologie medicale
pub_type： 杂志文章
doi：10.1016/j.mycmed.2012.06.001
更新日期：2012-09-01 00:00:00
abstract：INTRODUCTION:Candida albicans is the most prevalent fungal pathogen in humans. Due to the development of drug resistance, there is today a need for new antifungal agents for the efficient management of C. albicans infections. Therefore, we reviewed antifungal activity, mechanisms of action, possible synergism with anti...
journal_title：Journal de mycologie medicale
pub_type： 杂志文章,评审
doi：10.1016/j.mycmed.2016.10.002
更新日期：2017-03-01 00:00:00
abstract：:Candida spp. is a common cause of invasive fungal disease. The aim of this study was to examine the susceptibility of Candida spp. to fluconazole, itraconazole and voriconazole and explore the correlation between triazoles susceptibility. The antifungal susceptibility in the present study was measured by ATB Fungus 3 ...
journal_title：Journal de mycologie medicale
pub_type： 杂志文章
doi：10.1016/j.mycmed.2018.03.005
更新日期：2018-06-01 00:00:00
abstract：OBJECTIVE:The objective of this study was to produce the bioactive fermented product by the microbial fermentation of cabbage (Brassica oleracea) using a bacterial strain Pectobacterium atrosepticum which was assessed for its antimycotic efficacy against pathogenic isolates of Candida species. MATERIALS AND METHODS:An...
journal_title：Journal de mycologie medicale
pub_type： 杂志文章
doi：10.1016/j.mycmed.2011.11.004
更新日期：2012-03-01 00:00:00
abstract：INTRODUCTION:Comparing the activities of secreted enzymes in different fungal species can improve our understanding of their pathogenic role. Secretion of various enzymes by Candida species has been considered for determination of their virulence in different Candida infections including vulvovaginitis. AIMS:The aim o...
journal_title：Journal de mycologie medicale
pub_type： 杂志文章
doi：10.1016/j.mycmed.2017.01.009
更新日期：2017-06-01 00:00:00
abstract：OBJECTIVE:To determine the fungal species isolated from skin lesions of different animals suspected of having dermatomycoses and their prevalence in different regions of Iran. MATERIALS AND METHODS:A total of 1011 animals (292 dogs, 229 cats, 168 horses, 100 camels, 98 cows, 60 squirrels, 37 birds, 15 sheep, 6 goats, ...
journal_title：Journal de mycologie medicale
pub_type： 杂志文章
doi：10.1016/j.mycmed.2016.04.007
更新日期：2016-06-01 00:00:00
abstract：:Human and animal mycoses become more frequent and more resistant to traditional treatments. In this work, we tested the in vitro antifungal activity of acetonic extracts of Punica granatum L., Quercus suber L. and Vicia faba L. against seven pathogen fungi and the in vivo antifungal activity against Candida albicans a...
journal_title：Journal de mycologie medicale
pub_type： 杂志文章
doi：10.1016/j.mycmed.2016.10.004
更新日期：2017-03-01 00:00:00
abstract：:To date, there has been no comprehensive review of the epidemiology, risk factors, species distribution, and outcomes of candidemia in Iran. This study aimed to perform a systematic review and meta-analysis of all reported candidemia cases in Iran until December 2015. The review process occurred in three steps, namely...
journal_title：Journal de mycologie medicale
pub_type： 杂志文章,meta分析,评审
doi：10.1016/j.mycmed.2017.02.007
更新日期：2017-06-01 00:00:00
abstract：:We present the case of an actinomycotic mycetoma of the foot due to Actinomycetes viscosus. It evolved for nine years on the foot of a 26-year-old patient from a rural environment: Douar Inezgane (city in southern Morocco). Bacteriological study of the skin and grains confirmed the diagnosis. It showed positive bacill...
journal_title：Journal de mycologie medicale
pub_type： 杂志文章
doi：10.1016/j.mycmed.2014.10.025
更新日期：2015-03-01 00:00:00
abstract：UNLABELLED:Yeasts occur as part of the normal human microbiota. Nevertheless, some species are opportunistic, affecting immunocompromised patients such as those undergoing oncologic treatment. OBJECTIVE:To detect the presence of yeasts in patients suffering from head and neck cancer who are receiving radiation therapy...
journal_title：Journal de mycologie medicale
pub_type： 杂志文章
doi：10.1016/j.mycmed.2012.08.002
更新日期：2012-12-01 00:00:00
abstract：OBJECTIVE:The increasing importance of dermatophytoses and emerging resistance of dermatophytes to current synthetic antifungals have stimulated the search for safer and more effective alternative drugs from natural sources. The present study was carried out to identify antagonistic bacteria of soil origin with strong ...
journal_title：Journal de mycologie medicale
pub_type： 杂志文章
doi：10.1016/j.mycmed.2014.01.117
更新日期：2014-06-01 00:00:00
abstract：:The growing trends of emergence of antifungal-resistant Candida strains has recently been inspired the researchers to design new antifungal agents with novel mechanisms of action. Glabridin is an originally natural substrate with multiple biological activities which propose it as a novel anticancer, antimicrobial and ...
journal_title：Journal de mycologie medicale
pub_type： 杂志文章
doi：10.1016/j.mycmed.2017.05.002
更新日期：2017-09-01 00:00:00
abstract：:To study invasive pulmonary Aspergillosis (IPA), we depleted neutrophils in mice using the monoclonal antibody anti-Gr-1/Ly-6G. Immunocompetent and neutropenic mice were infected via intratracheal with conidia of Aspergillus fumigatus clinical isolates, characterized as either higher or lower elastase producers. Neutr...
journal_title：Journal de mycologie medicale
pub_type： 杂志文章
doi：10.1016/j.mycmed.2018.10.003
更新日期：2019-06-01 00:00:00
abstract：:Emericella nidulans is a species that has only rarely been implicated in human disease after cataract surgery. Here, we report the first postoperative case in the literature, as far as we know. The patient was a 50-year-old patient presented with mild anterior uveitis one week after cataract surgery, and hypopion deve...
journal_title：Journal de mycologie medicale
pub_type： 杂志文章
doi：10.1016/j.mycmed.2015.12.010
更新日期：2016-09-01 00:00:00
abstract：:In Algeria, many bacterial biofilms have been studied but those of fungal origin, particularly those due to the yeast Candida albicans remained unidentified. The present study was performed at the Chabane Hamdoune hospital in Maghnia (Algeria), where 51 strains of C. albicans representing 16.94% of all taken samples w...
journal_title：Journal de mycologie medicale
pub_type： 杂志文章
doi：10.1016/j.mycmed.2011.07.006
更新日期：2011-09-01 00:00:00
abstract：OBJECTIVE:This study was carried out to show possible similarities between discoid lupus erythematosus clinical signs and histopathological findings and dermatophytosis. PATIENT AND METHODS:A 43-year-old woman with diffused erythematous scaling lesions on her neck was studied. Skin biopsy was performed using H&E and P...
journal_title：Journal de mycologie medicale
pub_type： 杂志文章
doi：10.1016/j.mycmed.2011.12.001
更新日期：2012-03-01 00:00:00
abstract：OBJECTIVE:The aim of this study was the detection of Aspergillus species and Mycobacterium tuberculosis together in bronchoalveolar lavage (BAL) using of multiplex PCR. MATERIAL AND METHODS:In this study, from September 2012 until June 2013, 100 bronchoalveolar lavage (BAL) specimens were collected from patients suspe...
journal_title：Journal de mycologie medicale
pub_type： 杂志文章
doi：10.1016/j.mycmed.2015.02.041
更新日期：2015-06-01 00:00:00
abstract：OBJECTIVE:Candida parapsilosis species complex, an important set of non-albicans Candida species, is known to cause candidaemia particularly in neonates and infants. However, the incidence has increased in recent years, owing to higher numbers of at individuals at risk for these infections. Our objective was to evaluat...
journal_title：Journal de mycologie medicale
pub_type： 杂志文章
doi：10.1016/j.mycmed.2020.100968
更新日期：2020-09-01 00:00:00
abstract：:Malassezia pachydermatis is an important opportunistic agent of dermatitis and otitis in dogs. M. pachydermatis is generally treated with topical therapies using combinations of antifungal, antimicrobial and anti-inflammatory agents. We investigated the in vitro activities of carvacrol (CRV), cinnamaldehyde (CIN) and ...
journal_title：Journal de mycologie medicale
pub_type： 杂志文章
doi：10.1016/j.mycmed.2019.08.003
更新日期：2019-12-01 00:00:00
abstract：:Mucormycosis is a progressive, opportunistic fungal infection with a high risk of mortality. Also mucormycosis may attack any organ system and may be accompanied by hemodynamic instability and difficult airway management. This study aimed to evaluate the anesthetic management of patients undergoing surgical resection ...
journal_title：Journal de mycologie medicale
pub_type： 杂志文章
doi：10.1016/j.mycmed.2019.07.001
更新日期：2019-09-01 00:00:00
