Abstract:
INTRODUCTION:Comparing the activities of secreted enzymes in different fungal species can improve our understanding of their pathogenic role. Secretion of various enzymes by Candida species has been considered for determination of their virulence in different Candida infections including vulvovaginitis. AIMS:The aim of this study was to determine and compare the activity of secreted enzymes in Candidia strains isolated from women suspected to vulvovaginal candidiasis (VVC) and referred to some health centers in Khuzestan, Southwestern Iran. PATIENTS AND METHODS:The vaginal secretion samples were taken by swap from 250 suspected women with symptoms of vulvovaginal candidiasis and cultured on CHROMagar Candida medium. Identification of the isolated Candida from culture positive samples performed by the color of colonies and some standard mycological procedures. Activities of phospholipase, hemolysin-α, hemolysin-β, esterase and proteinase were measured in vitro by standard laboratory protocols. The enzymatic activity index (EAI) was calculated for each enzyme in accordance to relevant protocols. RESULTS:Totally in eighty cases (32%), a Candida strain was isolated which found to be as 52 (65%) Candida albicans; 12 (15%) C. glabrata; 10 (12.5%) C. dubliniensis; 4 (5%) C. krusei, C. tropicalis and C. parapsilosis species (each=1; 1.3%). Among C. albicans strains, 89.1% produced all studied enzymes, while 86% of C. glabrata strains failed to produce proteinase and phospholipase. The EAIs in decreasing order were as hemolysin-β=0.2895, hemolysin-α=0.5420, esterase=0.5753, proteinase=0.7413, and phospholipase=0.7446, respectively. Activity of phospholipase, esterase and proteinase secreted by C. albicans and C. dubliniensis were significantly more than those released by C. glabrata and C. krusei, while 86% of C. glabrata strains did not show esterase activity. On the other hand, the activity rates of hemolysin α and β among all studied isolates were almost similar. CONCLUSION:In the present study, the prevalence of VVC among investigated women was higher than the previous report from Khuzestan but C. albicans has yet remained the predominant agent of VVC in this area. Given to the EAI, the virulence of C. albicans in VVC can be mediated by phospholipase, esterase and proteinases.
journal_name
J Mycol Medjournal_title
Journal de mycologie medicaleauthors
Fatahinia M,Halvaeezadeh M,Rezaei-Matehkolaei Adoi
10.1016/j.mycmed.2017.01.009subject
Has Abstractpub_date
2017-06-01 00:00:00pages
188-194issue
2eissn
1156-5233issn
1773-0449pii
S1156-5233(16)30122-6journal_volume
27pub_type
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journal_title:Journal de mycologie medicale
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doi:10.1016/j.mycmed.2018.03.008
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journal_title:Journal de mycologie medicale
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doi:10.1016/j.mycmed.2014.10.022
更新日期:2015-03-01 00:00:00
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journal_title:Journal de mycologie medicale
pub_type: 杂志文章
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更新日期:2016-09-01 00:00:00
abstract:INTRODUCTION:Candida albicans is the most prevalent fungal pathogen in humans. Due to the development of drug resistance, there is today a need for new antifungal agents for the efficient management of C. albicans infections. Therefore, we reviewed antifungal activity, mechanisms of action, possible synergism with anti...
journal_title:Journal de mycologie medicale
pub_type: 杂志文章,评审
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abstract::Symptomatic candiduria often occurs in patients with indwelling bladder catheters or immunocompromised host. Isolation of Candida in urine in high-risk patients should primarily be considered as a marker for candidemia. Hematological and genitourinary malignancies are one of the main risk factors associated with Candi...
journal_title:Journal de mycologie medicale
pub_type: 杂志文章,评审
doi:10.1016/j.mycmed.2017.01.006
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abstract::Tineabarbae is a rare form of dermatophytosis that affects hair follicles of the beard and moustache. Dermoscopy could prove useful to identify parasitism of hair of the beard, just as it has proven useful in the diagnosis of Tineacapitis. We present the first fully documented case series of T. barbae with clinical, d...
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journal_title:Journal de mycologie medicale
pub_type: 杂志文章
doi:10.1016/j.mycmed.2016.03.002
更新日期:2016-09-01 00:00:00
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journal_title:Journal de mycologie medicale
pub_type: 杂志文章
doi:10.1016/j.mycmed.2017.05.002
更新日期:2017-09-01 00:00:00
abstract:OBJECTIVE:The effect of candidemia on immunologic parameters in breast tumor bearing patients is not well studied. Here, we hypothesised that candidemia in the tumor background may change the outcome of immunologic parameters and tumor condition. METHOD:Mice were divided into four groups, including normal, tumor, Cand...
journal_title:Journal de mycologie medicale
pub_type: 杂志文章
doi:10.1016/j.mycmed.2018.10.006
更新日期:2019-04-01 00:00:00
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journal_title:Journal de mycologie medicale
pub_type: 杂志文章
doi:10.1016/j.mycmed.2019.100905
更新日期:2020-04-01 00:00:00
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journal_title:Journal de mycologie medicale
pub_type: 杂志文章
doi:10.1016/j.mycmed.2014.03.004
更新日期:2014-09-01 00:00:00
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journal_title:Journal de mycologie medicale
pub_type: 杂志文章
doi:10.1016/j.mycmed.2020.101081
更新日期:2020-11-18 00:00:00
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journal_title:Journal de mycologie medicale
pub_type: 杂志文章
doi:10.1016/j.mycmed.2018.09.002
更新日期:2018-12-01 00:00:00
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journal_title:Journal de mycologie medicale
pub_type: 杂志文章
doi:10.1016/j.mycmed.2017.12.002
更新日期:2018-03-01 00:00:00
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journal_title:Journal de mycologie medicale
pub_type: 杂志文章
doi:10.1016/j.mycmed.2014.09.002
更新日期:2015-03-01 00:00:00
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journal_title:Journal de mycologie medicale
pub_type: 杂志文章
doi:10.1016/j.mycmed.2011.12.001
更新日期:2012-03-01 00:00:00
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doi:10.1016/j.mycmed.2010.11.005
更新日期:2011-03-01 00:00:00
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更新日期:2012-09-01 00:00:00
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journal_title:Journal de mycologie medicale
pub_type: 杂志文章,评审
doi:10.1016/j.mycmed.2012.04.004
更新日期:2012-06-01 00:00:00
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journal_title:Journal de mycologie medicale
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doi:10.1016/j.mycmed.2016.10.004
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journal_title:Journal de mycologie medicale
pub_type: 杂志文章
doi:10.1016/j.mycmed.2013.10.002
更新日期:2014-03-01 00:00:00
abstract:BACKGROUND:Candidemia is a nosocomial infection of increasing importance, associated with high morbidity and mortality. The aim of this study is to describe the species distribution, risk factors, management and outcomes of patients with candidemia. METHODS:We conducted a retrospective study at Centro Hospitalar Unive...
journal_title:Journal de mycologie medicale
pub_type: 杂志文章
doi:10.1016/j.mycmed.2019.08.002
更新日期:2019-12-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/j.mycmed.2019.07.001
更新日期:2019-09-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/j.mycmed.2018.10.003
更新日期:2019-06-01 00:00:00
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journal_title:Journal de mycologie medicale
pub_type: 杂志文章
doi:10.1016/j.mycmed.2014.08.004
更新日期:2014-12-01 00:00:00
abstract:BACKGROUND AND OBJECTIVE:Vulvovaginal candidiasis (VVC) is the most prevalent vaginitis in women, accounting for 10 million medical referrals a year. Vaginal clotrimazole is a drug of choice for VVC treatment. However, increased drug resistance to this microorganism has led to an interest in naturally derived antifunga...
journal_title:Journal de mycologie medicale
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.mycmed.2017.07.003
更新日期:2017-12-01 00:00:00
abstract:OBJECTIVE:Candida parapsilosis species complex, an important set of non-albicans Candida species, is known to cause candidaemia particularly in neonates and infants. However, the incidence has increased in recent years, owing to higher numbers of at individuals at risk for these infections. Our objective was to evaluat...
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pub_type: 杂志文章
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更新日期:2020-09-01 00:00:00